Mucinous adenocarcinoma of gall bladder: a case report

Ashwini Radhakishan Tangde, Santosh Govind Rathod, Anil R. Joshi, Rajan S. Bindu


Gall bladder carcinoma is the fifth most common malignancy of gastrointestinal tract. Mucinous carcinoma of gall bladder is very rare variant of gall bladder carcinoma. Only 20 cases of mucinous carcinoma reported till now. We report one such case of 55yr old female patient presented to our hospital with complaining of pain in right hypochondriac region and vomiting since, one month. Radiological examination revealed neoplastic thickening of gall bladder neck with cholelithiasis. Cholecystectomy was performed and specimen showed glistening grey white infiltrative firm solid mass at the neck of gall bladder. On microscopic examination showed mucinous adenocarcinoma. Tumour comprised of cystically dilated mucin filled glands. Tumour was seen infiltrating into muscle layer.


Cholelithiasis, Gall bladder, Mucinous adenocarcinoma

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Albores-Saavedra J, Menck HR, Scoazec JC, Soehendra N, Wittekind C, Sriram PV, et al. Carcinoma of the gallbladder and extrahepatic bile ducts. In: Hamilton SR, Aaltonen LA, editors. WHO Classification of Tumors. Pathology and Genetics of Tumors of the Digestive system. Lyon: IARC Press; 2000. p. 206-12.

Adsay VN, Klimstra DS. Benign and Malignant Tumors of the Gallbladder and Extrahepatic Biliary Tract. In: Odze RD, Goldblum JR, editors. Surgical pathology of the GI tract, liver, biliary tract, and pancreas. 2nd ed. Philadelphia: Saunders Elsevier. 2009; pp.857–70.

Adsay VN. Gallbladder, Extrahepatic Biliary Tree, and Ampulla. In: Mills SE, editor. Sternberg’s Diagnostic Surgical Pathology. 5th ed. Lippincott Williams & Wilkins. 2010; pp.1620–4.

Gupte AP, Chaturvedi R, Patil YL, Joshi SA. Pure mucinous (colloid) adenocarcinoma of the gallbladder-a rare phenotype. Oncology, Gastroenterology and Hepatology Reports. 2013;2(1):27.

Dursun N, Escalona OT, Roa JC, Basturk O, Bagci P, Cakir A, Cheng J, Sarmiento J, Losada H, Kong SY, Ducato L. Mucinous carcinomas of the gallbladder: clinicopathologic analysis of 15 cases identified in 606 carcinomas. Archives of pathology & laboratory medicine. 2012;136(11):1347-58.

Brunicardi FC, Anderson DK, editors. Schwartz’s Principles of Surgery. 8th ed. McGraw-Hill’s. 2007.

Blechacz B, Gores GJ. Tumors of the bile ducts, gallbladder, and ampulla. Gastrointestinal and Liver Disease. 2010;8:1171-83.

Barcia JJ, Rodrı́guez A, Siri L, Masllorens A, Szwebel P, Acosta G. Gallbladder carcinoma in the “hospital de clinicas” of Uruguay: 1998–2002. A clinicopathologic study of five cases in 802 cholecystectomies. Annals of diagnostic pathology. 2004;8(1):1-5.

Joo YE, Kim HS, Choi SK, Rew JS, Kim HJ, Kang HK, et al. Case of mucinous adenocarcinoma with porcelain gallbladder. J Gastroenterol Hepatol. 2003 Aug 1;18(8):995-8.

Yamamoto A, Ozeki Y, Ito Y, Horita R, Saji S, Sugiyama H, Matsunaga K. A case of well differentiated mucinous carcinoma of the gallbladder. Nihon Shokakibyo Gakkai zasshi= Jap J Gastro-enterol. 2010;107(11):1821-7.