Clinical profile of dengue fever in a tertiary care centre in North Kerala
DOI:
https://doi.org/10.18203/2320-6012.ijrms20174172Keywords:
Dengue fever, Dengue shock syndrome, Dengue hemorragic fever, Igm antibodyAbstract
Background: Dengue fever is the most common arboviral disease and fifty percent of world population is at risk. Frequent outbreaks are reported from all states of our country and incidence increases every year. This case study is of 305 patients from Academy of Medical Sciences, which is a tertiary care centre and research Institute in North Kerala. The objective of this study was to study the clinical profile of dengue fever.
Methods: Study was prospective observational study conducted during the epidemic for a period of one year. All the cases which fulfilled WHO criteria for diagnosis of dengue fever and those who are positive for IGM antibody detected by enzymelinked immunosorbent assay (IgM ELISA) were only included in this study.
Results: There is male preponderance, and those above the age of 30 years affected more. All patients had fever. Gastrointestinal manifestation like nausea and vomiting were commonly observed symptoms. Hepatomegaly, rash and conjuctival suffusion were important physical findings, whereas splenomegaly noted only in 8.2% cases. Thrombocytopenia is noticed in 73.96%.
Conclusions: The mortality is 2.6%. Hypotension and thrombocytopenia are the two important determinants of mortality. Dengue Shock syndrome and Dengue Hemorrhagic Fever were relatively less when compared to other epidemics from different regions.
References
Dengue hemorrhagic fever, diagnosis, treatment, prevention and control. 2nd edition, Geneva World Health Organisation; 1997.
Rothman AL. Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms. Nature reviews. Immunol. 2011;11(8):532.
Suzzane MS. Dengue. Medscape, 2014. Available at http://emedicine.medscape. com/article/215840.
CDC. Imported dengue- United States, 1997 and 1998. Morb Mortal Wkly Rep. 2000;49:248-5.
Engelthaler DM, Fink TM, Levy CE, Leslie MJ. The reemergence of Aedes aegypti in Arizona. Emerg Infect Dis. 1997;3:241-2.
Shah V, Jain U. Clinical profile of patients with Dengue fever in a tertiary care teaching hospital. Int J Med Sci Public Health. 2017;6;165-8.
Chhotala YH, Suva CM. A study of clinical profile of Dengue fever in a tertiary care hospital of Jamnagar, Gujarat, India. Int J Res Med Sci. 2016:4500-4.
Srikiatkhachorn A, Gibbons RV, Green S, Libraty DH, Thomas SJ, et al. Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005. Clin Infect Dis. 2010;50:1135-43.
Mohan DK, Shiddappa, Dhananjaya M. A study of clinical profile of dengue fever in a tertiary care teaching Hospital. Sch J AppMed Sci. 2013;1:280-2.
Rachel D, Rajamohanan, Philip AZ. A study of clinical profile of dengue fever in Kollam, Kerala, India. Dengue Bulletin. 2005;29:197-202.
Munde DD, Shetkar UB. Clinical feature sand haematological profile of dengue fever. Indian J Appl Res. 2013;3:131-2.
Mandal SK, Ganguly J, Koelina Sil. Clinical profiles of dengue fever in a teaching hospital of eastern india. Nat J Med Res. 2013;3:173-6.
Nadia A, Malik M, Jamil A, Jahangir M, Tirmiz N, Majid A, et al. Cutaneous manifestations in patients of dengue fever. J Pak Assoc Dermatol. 2012;22:320-4.
Muniraja PK, Swapna M, Mashyastha R. Clinical manifestations and biochemical profile of dengue fever in a tertiary care centre. Internat J Clin Cases Invest. 2013;5:72-82.
Deshwal R, Qureshi MI, Singh R. Clinical and laboratory profile of dengue fever. J Associat Physic India. 2015;63:30-2.
Adhikari P. Dengue fever profile in Karnataka and lesser known diagnostic markers. Medicine Update 2006;16:38.