Comparison of the efficiency of the nebulization of salbutamol, epinephrine and normal saline on treatment of bronchiolitis

Authors

  • Rakotomalala Rivo Lova Herilanto Department of Pediatric, University Hospital, Anosiala, Antananarivo, Madagascar
  • Lovaniaina Ravelomanana Department of Pediatric, University Hospital for Mother and Child, Ambohimiandra, Antananarivo, Madagascar
  • Andriatahirintsoa Emilson J. P. R. Department of Pediatric, University Hospital, Anosiala, Antananarivo, Madagascar
  • Tsifiregna Rosa Lalao Department of Pediatric, Soavinandriana Hospital, Antananarivo, Madagascar
  • Ravelomanana Noeline Department of Pediatric, University Hospital for Mother and Child, Ambohimiandra, Antananarivo, Madagascar

DOI:

https://doi.org/10.18203/2320-6012.ijrms20164057

Keywords:

Bronchiolitis, Bronchodilatator, Epinephrine, Normal saline, Salbutamol

Abstract

Background: Bronchiolitis is a frequent cause of hospitalization. Despite the frequency of this pathology, there is not a single, widely practiced evidence-driven treatment especially using of nebulization. Present purpose was to compare which is efficient: nebulized salbutamol, epinephrine or normal saline.

Methods: We have preceded to a prospective study from January 1st 2011 to March 31st 2012 including children between 29 days old and 2 years old.

Results: We have included 90 patients divided in three groups and received nebulized salbutamol, epinephrine or normal saline. There was no real difference in the variables of the groups: clinical score, oxygen saturation, heart rate, temperature and weight but the hospitalization duration was shorter in the group who have been cured by normal saline

Conclusions: This study shows that salbutamol, epinephrine and normal saline can be used in the same situation but the normal saline has more advantages because of his low coast and the absence of risk of side effects.

References

American Academy of Pediatrics Subcommitee on diagnosis and management of bronchioloitis. Diagnosis and management of bronchiolitis. Pediatrics. 2006;118:1774-93.

Smyth RL, Openshaw PJM. Bronchiolitis. Lancet. 2006;368:312-22.

Henderson FW, Clyde WA Jr, Collier AM, Denny FW, Senior RJ, Sheaffer Cl, et al. The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice. J Pediatr. 1979;95:183-90.

Grimprel E. Epidemiology of infant bronchiolitis in France. Arch Pediatr. 2001;8(Suppl 1):83S-92S.

Scarfone RJ. Controversies in the treatment of bronchiolitis. Curr Opin Pediatr. 2005;17:62-6.

Bush A, Thomson AH. Acute bronchiolitis. BMJ. 2007;335:1037-41.

Consensus Conference. Management of bronchiolitis in infant. ANAES. 2000.

Plint AC, Johnson DW, Patel H. Epinephrine and dexamethasone in children with bronchiolitis. N Engl J Med. 2009;360:2079-89.

Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP. Nebulized hypertonic saline solution for acute bronchiolitis in infants.Cochrane Database Syst Rev. 2008;4:CD 006458.

Patel H, Platt RW, Pekeles GS, Ducharme FM. A randomized controlled trial of the effectiveness of nebulized therapy with epinephrine compared with albuterol and saline in infants hospitalizes for acute viral bronchiolitis. J Pediatr. 2002;141:818-24.

Wainwright C, Altamirano L, Cheney M, Cheney J, Barber S, Price D, Moloney S, et al. A multicenter, randomized, double-blind, controlled trial of nebulized epinephrine in infants with acute bronchiolitis. N Engl J Med. 2003;349:27-35.

Anil AB, Anil M, Saglam AB, Cetin N, Bal A, Aksu N. High volume normal saline alone is as effective as nebulized salbutamol-normal saline, epinephrine-normal saline, and 3% saline in mild bronchiolitis. Pediatric Pulmonology. 2010;45:41-7.

Tal G, Cesar K, Oron A, Houri S, Ballin A, Mandelberg A. Hypertonic saline/epinephrine treatment in hospitalized infants with viral bronchiolitis reduces hospitalization stay: 2 years experience. Isr Med Assoc J. 2006;8:169-73.

Wang E, Milner R, Navas J, Maj H. Observe agreement for respiratory signs and oxymetry in infants hospitalized with lower respiratory infections. Am Rev Respir Dis. 1992;145:106-9.

Patel H, Platt R, Lozano JM, Wang EEL. Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev. 2004;(3):CD004878.

Gadomski AM, Bhasale AL,bronchodilatators for bronchiolitis.Cochrane Database Syst Rev. 2006;(3):CD001262.

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Published

2016-12-16

How to Cite

Herilanto, R. R. L., Ravelomanana, L., P. R., A. E. J., Lalao, T. R., & Noeline, R. (2016). Comparison of the efficiency of the nebulization of salbutamol, epinephrine and normal saline on treatment of bronchiolitis. International Journal of Research in Medical Sciences, 4(12), 5108–5111. https://doi.org/10.18203/2320-6012.ijrms20164057

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Original Research Articles