Correlation of lipid profile in patients with severity of liver disease: a cross sectional study in a tertiary care hospital

Hashik P. Muhammed, Kezhakkut Jayaraj


Background: Many previous studies concluded variation in the lipid parameters such as total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) with severity of liver disease. Hence, this study was conducted to find out the correlation of lipid profile in patients with severe liver disease.

Methods: A cross sectional study which included 170 patients admitted with chronic liver disease. Severity of liver disease according to Child Pugh Turcotte Score. The patients were subjected to routine investigation and fasting lipid profile test. Correlation was studied using the Pearson correlation coefficient and the comparison of lipid parameters was also done.

Results: Total of 170 consecutive chronic liver disease patients were analysed over a period of one year. Majority of the patients were of the age 51 to 60 years (39.8%). Among the total, 24 patients were in Child Pugh Turcotte Score class A, 47 patients were in class B and 52 were patients in class C. We could observe a significant (p<0.001) negative correlation of all the lipid profile parameters with the severity of liver disease.

Conclusions: Serum TC, LDL TG and HDL were decreased in patients with cirrhosis and they are inversely correlated to severity of disease.


Cirrhosis, Chronic liver disease, Child Pugh Turcotte Score, Lipid profile, Non-alcoholic seatohepatitis

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Anthony PP, Ishak KG, Nayak NC, Poulsen HE, Scheuer PJ, Sobin LH. The morphology of cirrhosis. Recommendations on definition, nomenclature, and classification by a working group sponsored by the World Health Organization. J Clin Pathol. 1978;31:395-414.

Council G, Assembly G. Global Burden of Liver Disease: A True Burden on Health Sciences and Economiesā€¼. Available from: publications/ e-wgn/ e-wgn-expert-point-of-view-articles-collection/global-burden-of-liver-disease-a-true-burden-on-health-sciences-and-economies

Lim YS, Kim WR. The global impact of hepatic fibrosis and end-stage liver disease. Clin Liver Dis. 2008;12:733-46.

Schuppan D, Afdhal NH. Liver cirrhosis. The Lancet. 2008;371(9615):838-51.

Nayak Maulik S, Shah RM. Study of lipid profile in cirrhotic patients. Nat J Inte Res Med. 2012;3:89-93.

Jiang ZG, Mukamal K, Tapper E, Robson SC, Tsugawa Y. Low LDL-C and high HDL-C levels are associated with elevated serum transaminases amongst adults in the United States: a cross-sectional study. PloS One. 2014;9(1):e85366.

McBride J, Shero ST, Smith Jr SC, Watson K, Peter WF, Eckel RH, et al. Copia Autorizada CDR. 2013.

Mandal SK, Sil K, Chatterjee S, Ganguly J, Chatterjee K, Sarkar P, et al. A study on lipid profiles in chronic liver diseases. Nat J Med Res. 2013;3:70-2.

Ghadir MR, Riahin AA, Havaspour A, Nooranipour M, Habibinejad AA. The relationship between lipid profile and severity of liver damage in cirrhotic patients Hepat Mon. 2010;10:285-8.

Sen A, Kumar J, Misra RP, Uddin M, Shukla PC. Lipid profile of patients having non-alcoholic fatty liver disease as per ultrasound findings in north Indian population: A retrospective observational study. J Med Allied Sci. 2013;3:59.

Warun Kumar MR, Harisha E. Assessment of lipid profile changes with respect to severity of liver dysfunction in cirrhosis of liver. Indian J Basic Appl Med Res. 2015:4:56-63.

Yasmin T, Siddiqui MSI. Study on Lipid Peroxidation and Lipid Profile Status in Patients of Liver Cirrhosis. Intl J Sci Res. 2015;4:2000-2.

Holkar SR, Vaishnav DM, Hivre MD. Serum lipid pattern in patients of liver cirrhosis. Int J Anat Physiol Biochem. 2014;1:9-12.

Shah SS, Desai HG J Assoc Physicians India. Apolipoprotein deficiency and chronic liver disease. 2001;49:274-8.

Habib A, Mihas AA, Abou-Assi SG, Williams LM, Gavis E, Pandak WM, Heuman DM. High-density lipoprotein cholesterol as an indicator of liver function and prognosis in noncholestatic cirrhotics. Clin Gastroenterol Hepatol. 2005;3:286-91.

He L, Hou X, Kanel G, Zeng N, Galicia V, Wang Y, et al., The Critical Role of AKT2 in Hepatic Steatosis Induced by PTEN Loss. Am J Pathol. 2010;176:2302-8.

Leavens KF, Easton RM, Shulman GI, Previs SF, Birnbaum MJ. Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metab. 2009;10:405-18.

Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci USA. 2004;101:7281-6.

Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes. 2001;50:1844-50.

Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest. 2005;115:1343-51.