Tulasi a magical herb and a boon for management of oral submucous fibrosis: a clinical study
DOI:
https://doi.org/10.18203/2320-6012.ijrms20174644Keywords:
Antioxidant, Burning sensation, Mouth opening, Oral submucous fibrosis, Pain associated with lesion, TulasiAbstract
Background: Plants are a good source of drugs in traditional and modern medicine. One among these plants is “tulasi” The queen of herbs” which is used in ayurveda for its diverse properties like antioxidant, analgesic, anti-inflammatory, antidiabetic, and others. It belongs to labiate family and is the most sacred and valued in traditional culture of India. AIMS of the study was to evaluate the efficacy of Tulasi in the treatment of OSMF.
Methods: The study included 20 individuals, females and males of age group 20-50yrs who visited the outpatient department who were diagnosed clinically as having OSMF, categorized according to pindborg’s classification. Patients were asked to apply 500mg of Tulasi medicine paste (Tulasi powder mixed with glycerine) twice daily for 1month and were recalled for follow up every week for 1month. All the clinical parameters - mouth opening, burning sensation, pain with the lesion and others were evaluated and recorded in specially designed proforma.
Results: Friedman test and wilcoxon signed rank test was used for statistical evaluation. Significant improvement with P value <0.05 was noticed in burning sensation, mouth opening and pain associated with the lesion.
Conclusions: The study concludes that Tulasi can be used as a main treatment modality in the management of patients with OSMF.
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References
Borle RM, Borle SR. Management of oral submucous fibrosis: A conservative approach. J Oral Maxillofac Surg. 1991;49:788-91.
Scully C. The oral cavity. In: Champion RH, Burton IL, Ebling FJ, editors. Textbook of Dermatology. 5th Ed. London: Oxford Blackwell Scientific Publication; 1992:2689-2276.
Saraswathi TR, Ranganathan K, Shanmugam S, Sowmya R, Narasimhan PD, Gunaseelan R. Prevalence of oral lesions in relation to habits: Cross-sectional study in South India. Indian J Dent Res. 2006;17:121-5.
George A, Sreenivasan BS, Sunil S, Varghese SS, Thomas J. Potentially malignant disorders of oral cavity. J Oral Maxillofac Pathol. 2011;2:95-100.
Canniff JP, Harvey W, Harris M. Oral submucous fibrosis: Its pathogenesis and management. Br Dent J. 1986;160:429-34.
Prakash P, Gupta N. Therapeutic uses of Ocimum sanctum linn (Tulsi) with a note on eugenol and its pharmacological actions: A short review. Indian J Physiol Pharmacol. 2005;49:125-31.
Kelm MA, Nair MG, Strasburg GM, DeWitt DL. Antioxidant and cyclo-oxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine. 2000;7:7-13.
Siddiqui HH. Safety of herbal drugs an overview. Drugs and over views. 1993;1(2):7-10.
Maheshwari R, Prasad M. Usage of Holy Basil for Various Aspects: Bull. Environ. Pharmacol. Life Sci. September 2012;1(10):67-9.
Maheshwari R, Rani B. multifaceted usage of holy basil. Journal of Drug Discovery and Therapeutics. 2013;1(5):1-4.
Aggarwal BB, Prasad S, Reuter S, Kannappan R, Yadev VR, Park B, et al. Identification of novel anti-inflammatory agents from ayurvedic medicine for prevention of chronic diseases: Reverse pharmacology and bedside to bench approach. Curr Drug Targets. 2011;12:1595-653.
MP Bhattathiry, 15 benefits of the holy basil Available at https://www.thoughtco.com/benefits-of-the-holy-basil-tulsi-1770035.
Gupta SK, Prakash J, Srivastava S. Validation of claim of Tulasi, Ocimum sanctum Linn as a medicinal plant. Indian J Experimental Biology 2002;40(7):765-73.
Srivastava A, Agarwal R, Chaturvedi TP, Chandra A, Singh OP. Clinical evaluation of the role of tulsi and turmeric in the management of oral submucous fibrosis: A pilot, prospective observational study. J Ayurveda Integr Med. 2015;6(1):45-9.
Alam S, Ali I, Giri KY, Gokkulakrishnan S, Natu SS, Faisal M, et al. Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116:717-24.
Karthik PM, Sande A, Ashwinirani SR, Nayak A, Pawar R, Patil P. Comparison of Mouth Opening with Different Non-Surgical Treatment Modalities in Oral Submucous Fibrosis. AJDDT. 2015;2(3):072-7.
Karemore TV, Motwani M. Evaluation of the effect of newer antioxidant lycopene in the treatment of oral submucous fibrosis. Indian J Dent Res. 2012;23:524-8.