An atypical case of fatal chikungunya infection in pregnancy
Keywords:Chikungunya, Disseminated intravascular coagulation, Hepatic, Pregnancy, Thrombocytopenia
Chikungunya viral infection is a mosquito borne illness which is known to have a limited course and complete recovery is seen in most of the patients. However the virus has been reported to have atypical manifestations and lethal complications have been reported in patients suffering from chikungunya infection. In the present outbreak of chikungunya virus in the national capital territory of Delhi we report a case of chikungunya fever in a pregnant female with no significant medical history. The patient developed thrombocytopenia, hepatic injury and disseminated intravascular coagulation and ultimately succumbed to the illness due to cardiovascular collapse.
Lahariya C, Pradhan SK. Emergence of Chikungunya virus in Indian subcontinent after 32 years: a review. J Vect Borne Dis. 2006;43:151-60.
Robinson MC. An epidemic of virus disease in Southern Province, Tanganyika territory, in 1952-53. Trans R Soc Trop Med Hyg. 1955;49:28-32.
Thiruvengadam KV, Kalyanasundaram V, Rajgopal J. Clinical and pathologic studies on Chikungunya fever in Madras city. Indian J Med Res. 1965;5:729-44.
Aikat BK, Konar NR, Banerjee G. Haemorrhagic fever in Calcutta area. Indian J Med Res. 1964;52:660-75.
Sam IC, Kamarulzaman A, Ong GS, Veriah RS, Ponnampalavanar S, Chan YF, AbuBakar S. Chikungunya virus associated death in Malaysia. Trop Biomed. 2010;27:343-7.
Powers AM, Logue CH. Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus. J Gen Virol. 2007;88:2363-77.
Economopoulou A, Dominguez M, Helynck B, Sissoko D, Wichmann O, Quenel P , et al. Atypical Chikungunya virus infections clinical manifestations, mortality and risk factors for severe disease during the 2005-2206 outbreak on Reunion. Epidemiol Infect. 2009;137:534-41.
Lemant J, Boisson V, Winer A, Thibault L, Andre H, Tixier F et al. Serious acute chikungunya virus infection requiring intensive care during the Reunion island outbreak in 2005-2006. Crit Care Med. 2008;36:2536-41.
Chua HH, Rashid KA, Law WC, Hamizah A, Chem YK, Khairul AH et al. A fatal case of Chikungunya virus infection with liver involvement. Med J Malaysia. 2010;65:83-4.
Torres JR, Codova L, Castro JS, Rodriguez L, Saravia V, Arvelaez J. Chikungunya fever: atypical and lethal cases in the western hemisphere. A Venezuelan experience. ID Cases. 2015;2:6-10.
Taksande A, Vilhekar K.Y. Neonatal Chikungunya infection. J Prev Infec Cont. 2015;1(8):1-3.
Robillard PY, Boumahni B, Gerardin P, Michault A, Fourmaintraux A, Shuffenceker I, et al. Vertical maternal fetal transmission of the Chikungunya virus. Presse Med. 2006;35:785-8.
Lenglet Y, Barau G, Robillard PY, Randrianaivo H, Michault A, Bouveret A et al. Chikungunya infection in pregnancy: Evidence for intrauterine infection in pregnant women and vertical transmission in the parturient. Survey of the Reunion Island Outbreak. J Gynecol Obstet Biol Reprod. 2006;35:578-83.