DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20175464

Pattern of lipid profile in type 2 diabetes mellitus-a study from north Bihar

Bhagwan Das, Durgesh kumar, Munish Kumar

Abstract


Background: Diabetes mellitus refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. Type 2 Diabetes Mellitus (DM) is a heterogeneous group of disorders characterized by variable degree of insulin resistance, impaired insulin secretion, and increased glucose production.

Methods: To study of pattern of lipid profile in type 2 diabetes mellitus, 100 cases of type 2 Diabetes Mellitus attending the tertiary care centre were selected. The result was compared with 25 healthy, non-obese, non- diabetic and non-hypertensive subjects.

Results: Triglyceride (TG) and very low-density lipoprotein (VLDL) were significantly higher whereas high density lipoprotein (HDL) levels lower in diabetics than healthy controls. Total cholesterol (TC) and low-density lipoprotein (LDL) were other fractions which were slightly above optimal levels in diabetics.

Conclusions: From our study, it was concluded that diabetes mellitus has a real impact on lipid metabolism.


Keywords


Diabetes, Lipid Profile, North Bihar

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References


Harrison’s principals of internal medicine, 18th ed.

;2:2967-8.

Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes research and clinical practice. 2011;94(3):311-21.

Anjana RM, Pradeepa R, Deepa M, Datta M, Sudha V, Unnikrishnan R, et al. ICMR–INDIAB Collaborative Study Group: Prevalence of diabetes and prediabetes (impaired fasting glucose and/or impaired glucose tolerance) in urban and rural India: phase I results of the Indian Council of Medical Research-INdia DIABetes (ICMR-INDIAB) study. Diabetologia. 201;54(12):3022-7.

Ramachandran A, Snehalatha C, Kapur A, Vijay V, Mohan V, Das AK, et al. Diabetes Epidemiology Study Group in India (DESI. High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey. Diabetologia. 2001;44(9):1094-101.

Verma NP, Mehta SP, Madhu S, Mather HM, Keen H. Prevalence of known diabetes in an urban Indian environment: the Darya Ganj diabetes survey. Brit Medic J (Clinic Res ed.). 1986;293(6544):423.

Mohan V, Deepa M, Deepa R, Shanthirani CS, Farooq S, Ganesan A, et al. Secular trends in the prevalence of diabetes and impaired glucose tolerance in urban South India-the Chennai Urban Rural Epidemiology Study (CURES-17). Diabetologia. 2006;49(6):1175-8.

Parikh RM. Diabetes and metabolic syndrome: Clinical Research & Reviews 2010;4: 10-12.

Harrison’s Principals of Internal Medicine, 18th

edition. Ch 344; 2985-6.

Mazzone T. Current concepts and controversies in the pathogenesis, prevention, and treatment of the macrovascular complications of diabetes. Translational Research. 2000;135(6):437-43.

Otamere HO, Aloamaka CP, Okokhere PO, Adisa WA. Lipid profile in diabetes mellitus; what impact has age and duration. Brit J Pharmacol Toxicol. 2011;2(3):135-7.

Albrki WM, Elzouki AN, El-Mansoury AM, Tashani OA. Lipid profiles in Libyan type II diabetics. J Sci Appls. 2007;1:18-23.

Donald S. Fong, Lloyd Aiello, Thomas W. Gardner, George L. King, George Blankenship, Jerry D. Cavallerano, et al. Diabetic Retinopathy. Ame Diab Asso. 2003:26(1): s99-s102

Ramachandran A. Socio-economic burden of diabetes in India. J Associ Physic Ind. 2007;55(L):9.

Samantha P, Venkateswrlu M, Siva Probodh V. Lipid profile levels in type-2 diabetes mellitus from the tribal population of Adilabad, Andhra Pradesh, India. J clinic Diag Res. 2012;(suppl-2)Vol-6(4):590-592.

Bijlani PK, Shah K, Raheja BS. HDL cholesterol in Diabetics. JAPI 1984;32:11-15.

Karlander SG, Gutniak MK, Efendic S. Effects of combination therapy with glyburide and insulin on serum lipid levels in NIDDM patients with secondary sulfonylurea failure. Diabetes care. 1991;14(11):963-7.