Retrospective analysis of biochemical profile of dengue infection in a tertiary care hospital
Abstract
Background: Dengue is an exceedingly common infection of the tropics. The aim of the research to study the biochemical parameters of serologically proven dengue cases.
Methods: The study included Dengue patients admitted in PSG Hospital between January 2011and December 2012.
Results: Analysis of aspartate aminotransferase results showed that 19.1% had two-fold rise, 13.3% had three-fold rise and 19.6% had more than threefold rise. Analysis of alanine aminotransferase showed that 35.7% had normal values, 14.95% had two-fold rise, 11.1% had three-fold rise and 11.5% had more than threefold rise. Serum proteins were normal in 35.7% and low in 19.6%. Analysis of serum albumin showed low values in 10.6% Serum sodium levels were low in 11.1% of patients. Albuminuria was positive in 53% of patients. Serum ionised calcium levels were low in 26.8% of patients.
Conclusions: The biochemical abnormalities noted in our study included include elevated liver enzymes, low sodium and ionised calcium levels, hypoalbuminemia and increased urine albumin excretion.
Keywords
Full Text:
PDFReferences
World Health Organization. Dengue guidelines for diagnosis, treatment, prevention and control new edition. Geneva, 2009. Available at http://www. who.int/rpc/guidelines/9789241547871/en/.
Souza LJ, Nogueira RM, Soares LC, Soares CE, Ribas BF, Alves FP, et al. The impact of dengue on liver function as evaluated by aminotransferase levels. Braz J Infec Dis. 2007;11(4):407-10.
Nguyen TL, Nguyen TH, Tieu NT. The impact of dengue haemorrhagic fever on liver function. Res virol. 1997;148(4):273-7.
Dahanayaka NJ, Agampodi SB, Arachchi UK, Vithange SP, Rajapakse R, Ranathunga K, et al. Dengue fever and ionized calcium levels: significance of detecting hypocalcaemia to predict severity of dengue. Ceyl Medic J. 2017;62(1).
Brito CA, Albuquerque MD, Lucena-Silva N. Plasma leakage detection in severe dengue: when serum albumin quantification plays a role?. Revista da Sociedade Brasileira de Medicina Tropical. 2007;40(2):220-3.
Rose J, Palanisamy A, Vijayarani H, Anna A. Electrolyte disturbance in Dengue infected patients Internat J Advanc Pharmacy, Biol Chemistr. 2014;3(4):933-6.
Bhagyamma SN, Sreenivasulu U, Shyam Prasad BR, Anuradha R, Durga T. Electrolyte disturbance in dengue infected patients: A hospital based study. Int J Res Health Sci. 2015;3(1):130-3.
Kumar ss, kanna s, palaniandavan s. Assessment of proteinuria for early diagnosis and risk prediction of dengue hemorrhagic fever/dengue shock syndrome in dengue infections. 2017;8(1):440-443.
Vasanwala FF, Thein TL, Leo YS, Gan VC, Hao Y, Lee LK, et al. Predictive value of proteinuria in adult dengue severity. PLoS Neglected Trop Dis. 2014;8(2):e2712.
Mendez A, Gonzalez G. Dengue haemorrhagic fever in children: ten years of clinical experience. Biomedica: revista del Instituto Nacional de Salud. 2003;23(2):180-93.