DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20175734

Pattern of histopathological lesions in lung autopsy

Chandni B. Patel, Komal Patel, Vasudha M. Bhagat, Pinkal Shah

Abstract


Background: A large number of pathologic conditions involve the lung parenchyma like inflammatory, neoplastic and others. The lungs are also involved in almost all terminal events of cardiovascular disease. Autopsy is an important and most useful way to find out the condition of internal organs and to evaluate any localized lesions or systemic disease and hence determine cause of death. Aims and objectives of study are to identify the histopathological spectrum of lung disease. To find out frequency of various lung pathologies in respect to age and sex.

Methods: This study was retrospective and done on 649 cases of medico legal autopsies. The tissue specimens were fixed and processed. Routine paraffin sectioning was done followed by Hematoxylene and eosin (H and E) staining. Special stains were done whenever required. Relevant clinical and postmortem findings, gross and microscopic examination findings were recorded.

Results: After thorough histopathological examinations, of total 649 cases, various pulmonary lesions were identified in 348(53.6%) cases while in 301(46.4%) cases no significant pathology was seen. Most commonly affected age group was 30-49 years 43.1% followed by age group of >60years 17.8%. Majority of diseased were male 285 (81.9%). Most common lung pathology found was Edema and congestion in 93 cases (26.72%), chronic venous congestion in 92 cases (26.44%) pneumonia in 65 cases (18.68%) followed by Tuberculosis/Tuberculous pneumonia in 29 cases (8.3%).

Conclusions: In our population, the present study reveals that infectious disease are still the most common cause of mortality, despite recent advances in diagnostic technology, the autopsy has remained an important complementary tool for identifying and understanding pathology of disease.

 


Keywords


Edema and congestion, Histomorphological pattern, Lung pathology in autopsy, Pneumonia, Tuberculosis

Full Text:

PDF

References


Udayashankar SK, Shashikala P, Kavita GU, Pruthvi D. Histomorphological pattern of lung in medicolegal autopsies. Internat J Sci Res. 2015;4(7):1937-9.

Mangal K, Dhakar P, Yadav A, Gupta K, Gandhi S. Magnitude of pulmonary disease-incidentally diagnosed on autopsy- at largest hospital & medical college of Rajasthan. Int J Cur Res Rev. 2016;8(8).

Selvambigai G, Amudhavalli S, Chakravarthi DCD, Ravi S. Histopathological study of lung in autopsy cases: a prospective study. Int J Res Med Sci. 2016;4(11):4816-9.

Chauhan G, Agrwal M, Thakkar N, Parghi B. Spectrum of histopathological lesion in lung autopsy. J Res Medic Dental Sci. 2015:3(2):109-12.

Tahir TM, Rehmna F, Anwar S, Kamal F. Pattern of pulmonary morphological lesions seen at autopsy. Biomedica. 2013;29:64-8.

Bal MS, Sethi PS, Suri AK, Bodal VK, Kaur G. Histopathological pattern in lung autopsies. JPAFMAT. 2008;8(2):29-31.

Amin NS, Shah PY, Patel RG, Khant VS, Prajapati SG. Histopathological alterations in lung tissue received as autopsy specimens- a study of 410 cases. Int J Med Sci Public Health. 2017;6.

Shweta, Mahajan D, Mahajan V, Angmo P. Histopathological pattern in lung autopsy in government medical college Jammu. J Evolut Medic Dent Sci. 2015;4(91):15694-6.

Kurawar RR, Vasaikar MS. Spectrum of Histomorphological Changes in Lungs at Autopsy: A 5 Year Study. Annals of Pathol Laborat Medic. 2017;4(1):A106-A112.

Garg M, Aggarwal AD, Singh S, Kataria SP. Tuberculous lesions at autopsy. J Indian Acad Forensic Med. 2011;33(2):116-9.

Khare P, Gupta R, Ahuja M, Khare N, Agarwal S, Bansal D. Prevalence of Lung Lesions at Autopsy: A Histopathological Study. J Clinic Diagnostic Res. 2017;11(5):EC13-6.