Chronic neutrophilic leukaemia-a rare haematological malignancy
Abstract
Chronic neutrophilic leukaemia is a rare myeloproliferative neoplasm. It requires exhaustive workup and puts a diagnostic challenge to the clinician as well as pathologist. It should be differentiated from chronic myelogenous leukemia and reactive neutrophilia. Prognosis of the disease is poor. Here we report a case presented to us with 4 months of fatigue and fever. Investigation shows leucocytosis with predominant neutrophilia, evaluated and diagnosed as Chronic Neutrophilic Leukaemia (CNL) according to revised WHO criteria.
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Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES. The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 2011;117(19):5019-32.
Elliott MA, Hanson CA, Dewald GW, Smoley SA, Lasho TL, Tefferi A, et al. WHO defined chronic neutrophilic leukemia: A long term analysis of 12 cases and a critical review of the literature. Leukemia. 2005;19:313-7.
Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Eng J Med. 2005;352(17):1779-90.
Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, et al. Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Eng J Med. 2013;368(19):1781-90.
Pardanani A, Lasho TL, Laborde RR, Elliott M, Hanson CA, Knudson RA, et al. CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia. Leukemia. 2013;27(9):1870-3.
Arber DA, Orazi A, Hasserjian R. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391-405.
Ziai J, Torres R, Tormey CA. Chronic Neutrophilic Leukemia: A Rare and Difficult Diagnosis of Exclusion. J Blood Disord Transfus. 2010;1:102.
Yassin MA, Kohla S, Al-Sabbagh A, Soliman AT, Yousif A, Moustafa A. A case of chronic neutrophilic leukemia successfully treated with pegylated interferon Alpha-2a. Clin Med Insights Case Rep. 2015;8:33-6.
Kako S, Kanda Y, Sato T, Goyam S, Noda N, Shoda E, et al. Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation. Am J Hematol. 2007;82:386-90.
Goto H, Hara T, Tsurumi H, Tanabashi S, Moriwaki H. Chronic neutrophilic leukemia with congenital Robertsonian translocation successfully treated with allogeneic bone marrow transplantation in a young man. Intern Med. 2009;48(7):563-7.
Quintás-Cardama A, Vaddi K, Liu P, Manshouri T, Li J, Scherle PA, et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood. 2010;115:3109-17.