A rare case of neomercazole induced hepatitis


  • Muralidhar Varma Department of Medicine, Kasturba Medical College, Manipal, Karnataka, India
  • Jaikaran Mansingh Department of Medicine, Kasturba Medical College, Manipal, Karnataka, India
  • Devyani Sivakumar Department of Medicine, Kasturba Medical College, Manipal, Karnataka, India
  • Rabia Dhalla Department of Medicine, Kasturba Medical College, Manipal, Karnataka, India
  • Sudha Vidyasagar Department of Medicine, Kasturba Medical College, Manipal, Karnataka, India
  • Nandakrishna B. Department of Medicine, Kasturba Medical College, Manipal, Karnataka, India




Antithyroid drugs, Drug-induced hepatotoxicity, Graves disease, Neomercazole


Neomercazole is one of the most commonly used drugs to treat hyperthyroidism. Common side effects include rash, hair loss and agranulocytosis. Hepatotoxicity is a common side effect of Propylthiouracil, the other major antithyroid drug, but it has been rarely described as a side effect of neomercazole. Here, a patient presents with hepatitis 6 months after starting neomercazole therapy for graves disease. Diagnosis is based on excluding other causes of hepatitis, and treatment involves removing the offending drug. This is followed by normalization of liver function. Rechallenging should not be done as it can lead to recurrence of symptoms.


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How to Cite

Varma, M., Mansingh, J., Sivakumar, D., Dhalla, R., Vidyasagar, S., & B., N. (2018). A rare case of neomercazole induced hepatitis. International Journal of Research in Medical Sciences, 6(5), 1812–1814. https://doi.org/10.18203/2320-6012.ijrms20181783



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