Clinical profile of dengue fever infection in patients admitted in NCMC medical college, Panipat, Haryana, India
DOI:
https://doi.org/10.18203/2320-6012.ijrms20180607Keywords:
Dengue fever, Leucopoenia, ThrombocytopeniaAbstract
Background: Dengue infections can result in a wide spectrum of disease severity ranging from an influenza-like illness (dengue fever; DF) to the life-threatening dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). The study was aimed to compare the clinical profile of all patients diagnosed with dengue viral infection at NCMC.
Methods: This retrospective study included 136 patients infected with dengue virus, age 2 years to 68 years. Laboratory and haematological data were included.
Results: Peak of infection occurred in Nov. 2017 and least number of cases were recorded in September 2017. Common clinical symptoms were fever, headache and myalgia. Common haematological abnormalities were thrombocytopenia and leucopoenia. All patients survived. There was no case of dengue hemorrhagic fever or dengue shock syndrome.
Conclusions: Significant differences in the clinical profile is possibly because of infection with different serotypes of dengue virus (DENV), concurrent/sequential infection of more than one serotype, and differences in host immune responses associated with host genetic variations.
References
WHO. Fact sheet No 117: Dengue and dengue haemorrhagic fever. (2008). Available at http://www.who.int/mediacentre/factsheets/fs117/e/.
Centers for Disease Control and Prevention. Dengue and dengue hemorrhagic fever: Information for health care practitioners-CDC division of vector-borne infectious diseases. Available at http://www.cdc.gov/ncidod/dvbid/ dengue/dengue-hcp.htm.
Malavige GN, Fernando S, Fernando DJ, Seneviratne SL. Dengue viral infections. Postgrad Med J. 2004;80:588-601.
Khan NA, Azhar EI, El-Fiky S, Madani HH, Abuljadial MA, Ashshi AM, et al. Clinical profile and outcome of hospitalized patients during first outbreak of dengue in Makkah, Saudi Arabia. Acta Trop. 2008;105:39-44.
Central Department of Statistics and Information. Kingdom of Saudi Arabia. Available at http://www.cdsi.gov.sa/showproductstandard.aspx?l id=26&pid=1005.
Ramos MM, Tomashek KM, Arguello DF, Luxemburger C, Quiñones L, Lang J, et al. Early clinical features of dengue infection in Puerto Rico. Trans R Soc Trop Med Hyg. 2009;103(9):878-84.
de Oliveira SA, Bastos Camacho LA, Fernandes Bruno L, de Gusmão RC, de Medeiros Pereira AC, Coca Velarde LG, et al. Acute arthropathy in patients with rash diseases: a comparative study. Clin Rheumatol. 2009;28(9):1067-71.
WHO. Dengue haemorrhagic fever: diagnosis, treatment, prevention and control, 2nd edition. Geneva, 1997. Available at http://www.who.int/csr/ resources/publications/dengue/Denguepublication/en/.
Griffais R, Andre PM, Thibon MK-tuple. Frequency in the human genome and polymerase chain reaction. Nucleic Acid Res. 1991;19:3887-91.
Ayyub M, Khazindar AM, Lubbad EH, Barlas S, Alfi AY, Al-Ukayli S. Characteristics of dengue fever in a large public hospital, Jeddah, Saudi Arabia. J Ayub Med Coll Abbottabad. 2006;18:9-13.
Coffey LL, Mertens E, Brehin AC, Fernandez-Garcia MD, Amara A, Després P, et al. Human genetic determinants of dengue virus susceptibility. Microbes Infect. 2009;11:143-56.
Balmaseda A, Hammond SN, Pérez L, Tellez Y, Saborío SI, Mercado JC, et al. Serotype-specific differences in clinical manifestations of dengue. Am J Trop Med Hyg. 2006;74:449-56.
Bharaj P, Chahar HS, Pandey A, Diddi K, Dar L, Guleria R. Concurrent infections by all four dengue virus serotypes during an outbreak of dengue in 2006 in Delhi, India. Virol J. 2008;5:1.
Loroño-Pino MA, Cropp CB, Farfán JA, Vorndam AV, Rodríguez-Angulo EM, Rosado-Paredes EP, et al. Common occurrence of concurrent infections by multiple dengue virus serotypes. Am J Trop Med Hyg. 1999;61:725-30.
Zaki A, Perera D, Jahan SS, Cardosa MJ. Phylogeny of dengue viruses circulating in Jeddah, Saudi Arabia: 1994 to 2006. Trop Med Int Health. 2008;13:584-92.
Wilder-Smith A, Gubler DJ. Geographic expansion of dengue: the impact of international travel. Med Clin North Am. 2008;92:1377-90.
Chaturvedi U, Nagar R, Shrivastava R. Dengue and dengue haemorrhagic fever: implications of host genetics. FEMS Immunol Med Microbiol. 2006;47:155-66.
Long HT, Hibberd ML, Hien TT, Dung NM, Van Ngoc T, Farrar J, et al. Patterns of gene transcript abundance in the blood of children with severe or uncomplicated dengue highlight differences in disease evolution and host response to dengue virus infection. J Infect Dis. 2009;199:537-46.
Swaminathan S, Khanna N. Dengue: recent advances in biology and current status of translational research. Curr Mol Med. 2009;9:152-73.
Crill WD, Hughes HR, Delorey MJ, Chang GJ. Humoral immune responses of dengue fever patients using epitope-specific serotype-2 virus-like particle antigens. PLoS ONE. 2009;4(4):e4991.
Shah MY, Naqash MM, Goel RK, Galhan D, Kumar S, Chhabra V, Saini A, et al. Clinical profile of dengue fever infection in patients admitted in tertiary care centre Agroha, Hisar, Haryana, India. Inter J Research Med Sci. 2017;4(6):2146-9.