DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20180322

Comparative study of serum ferritin and vitamin D in thalassemia patients with healthy controls

Shweta Gombar, Kiran Parihar, Mamta Choudhary

Abstract


Background: Thalassemia is the most common genetic disorder in humans; they are encountered among all ethnic groups and in almost every country around the world. Mostly occur in the regions surrounding the Mediterranean sea, hence the name. These are a group of hereditary haemolytic disorders characterized by impairment in the synthesis of globin chains of Hb. The present study aimed to find out the serum ferritin and vitamin D level in thalassemic children in the tertiary care hospital in Bikaner, western Rajasthan, India.

Methods: In this study 50 (27 male and 23 female) adult skulls were investigated to determine the type of asterion, its distance from important bony landmarks and also the nearby venous sinuses were measured.

Results: Level of serum ferritin was significantly high and vitamin D was significantly low (p-value<0.0001 for both) in thalassemic children.

Conclusions: In this study the role of serum ferritin and vitamin D has been explored. The extremely high level of ferritin was found due to the regular blood transfusion and consequent iron overload and low vitamin D was found due to impairment in liver functions among thalassemic children.


Keywords


Ferritin, Vitamin D, Thalassemia

Full Text:

PDF

References


Weatherall DJ, Clegg JB. Thalassemia – a global public health problem. Nature Med 1996;2:847-9.

Weatherall DJ, Clegg JB. Inherited Haemoglobin Disorders: An increasing global problem. Bull World Health Organ. 2001;79:12-704.

Nathan DG, Gunn RB. Thalassemia: the consequences of unbalanced haemoglobin synthesis. Am J Med. 1966;41(5):30-815.

Piomelli S, Karpatkin MH, Arzanian M, Zamani M, Becker MH, Geneiser N, et al. Hyper transfusion regimen in patients with Cooley's anaemia. Ann N Y Acad Sci. 1974;232(0):186-192.

Olivieri NF, Brittenham GM. Iron-chelating therapy and the treatment of Thalassemia. Blood. 1997;89(3):739-61.

Holick MF, Mac Laughlin JA, Clark MB, et al. Photosynthesis of pre vitamin D3 in human skin and the physiologic consequences. Science. 1980;210(4466):203-5.

Jaidev S, Meena V, Sangeeta P. Study of serum ferritin level, SGOT, SGPT and hepatitis B status in multi transfused thalassemia patients. JARBS. 2011;3(2):63-5.

Belhoul KM, Bakir ML, Saned MS, Kadhim AM, Musallam KM, Taher AT. Serum ferritin levels and endocrinopathy in medically treated patients with β thalassemia major. Ann Hematol. July 2012;91(7):14-107.

Mishra AK, Tiwari A. Iron overload in beta thalassemia major and intermedia patients. 2013;8(4):328-32.

Haghpanah S, Esmaeilzadeh M, Honar N, Hassani F, Dehbozorgian J, Rezaei N, et al. Relationship between serum hepcidin and ferritin levels in patients with thalassemia major and intermedia in Southern Iran. Iran Red Crescent Med J. 2015;17(7).

Wood JC, Claster S, Carson S, Menteer JD, Hofstra T, Khanna R et al. Vitamin D deficiency, cardiac iron and cardiac function in thalassemia major. Br J Haematol. 2008;141(6):891-4.

Fahim FM, Saad K, Askar EA, Eldin EN, Thabet AF. Growth parameters and vitamin d status in children with thalassemia major in upper Egypt. Int J Hematol Oncol Stem Cell Res. Haemoglobin. 2013; 7(4): 10-14.

Soliman A, De Sanctis V, Yassin M. Vitamin D status in thalassemia major: an Update. Mediterr J Hematol Infect Dis. 2013; 5(1).

Tzoulis P, Ang AL, Shah FT, Berovic M, Prescott E, Jones R et al. Prevalence of low bone mass and vitamin D deficiency in β-thalassemia major. Hemoglobin. 2014 Jun;38(3):173-8.