DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20180612

The incidence and spectrum of transfusion transmitted infections among the blood donors

Smita Mahapatra, Gopal Krushna Ray, Rashmita Panigrahi, Pankaj Parida

Abstract


Background: Transfusion Transmitted Infections (TTIs), particularly through the viruses lead to the major health problems and challenges faced by the transfusion services for the supply of safe blood and blood components. The objective of the study is to assess the incidence and spectrum of five TTIs like Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV), Malaria Parasites (MP) and Syphilis among both voluntary and replacement blood donors in a span of seven years.

Methods: Total 1, 38,994 voluntary and replacement blood donors were screened and 1,012 (0.73%) cases were seropositive of which 631 cases (0.64%) were found in voluntary donors and 381 cases (0.94%) were seen in replacement donors.

Results: Majority of the donors were reactive for HBV infection (0.5%) followed by HCV (0.17%), HIV (0.052%), Syphilis (0.001%) and malaria (0.0005%). There was increase in the trend of seroprevalence of TTIs from 0.35% (2010) to 1.43% (2016) over the period which is a matter of consideration.

Conclusions: It is therefore very important to continue preventive measures to combat this problem along with screening of donated blood units with highly sensitive test methods and post donation counselling of the seropositive donors for the prevention of further transmission risks.


Keywords


Hepatitis B virus, Hepatitis C virus, Human immunodeficiency virus, Seroprevalence, Transfusion transmitted infection

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References


Kalepoto GN, Bhally HS, Khaliq G. Epidemiology of blood-born viruses. A study of healthy blood donors in Sourthen Pakistan. J Pak Med Associates. 1996;27;703-6.

Bhattacharya P, Chandra PK, Datta S, Banerjee A, Chakraborty S, Rajendran K, et al. Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: Exploratory screening reveals high frequency of occult HBV infection. World Journal of Gastroenterology: WJG. 2007;13(27):3730.

Arora D, Arora B, Khetarpal A. Seroprevalence of HIV, HBV, HCV and Syphilis in blood donors in SourthenHarayana. Ind J Pathology Microbiol. 2010;53:308-9.

Kour G, Basu R, Kour P, Garg S. Pattern of infections among blood donors in a tertiary care center, a retrospective study. Medicine J India 2010;23:147-9.

Bhawani Y, Rao PR, Sudhakar V. Seroprevalence of transfusion transmitted infections among blood donors in tertiary care hospital of Andhra Pradesh. Biology and Medicine. 2010;12:45-48.

Chandrasekharan S, Pallanipan N, Krishnan V, MohanG, Chandrasejharan N. Relative prevalence of hepatits B Viral markers and Hepatitis C Virus antibodies (anti HCV) in Madurai, South India. Ind J Med Sci. 2000;547:270-3.

Srikrishna A, Sitalakshmi S, Damodar P. How safe are our safe donors? Ind J Pathology Microbiol. 1999;424:411-6.

Choudhury N, Ramesh V, Saraswat S, Naik S. Effectiveness of mandatory transmissible diseases screening in Indian blood donors. Ind J Med Res. 1995:101;229-32.

Dienstag JL, Isselbacher KJ. Acute viral hepatitis. Harrisons Principles of Internal Medicine. 2001;2:1721-36.

World Health Organisation. Hepatitis B. Fact sheet. Reviewed July 2017. cited august 2017. Available from: http: // www.who.int/entity/mediacentre/factsheets/fs204/en/.

Sharma RR, Cheema R, Vajpayee M, Rao U, Kumar S, Marwaha N, et al. Prevalence of markers of transfusion transmissible diseases in voluntary and replacement blood donors. National medical J India. 2004;17(1):19-21.

Gupta N, Kumar V, Kaur A. Seroprevalence of HIV, HBV, HCV and Syphilis in voluntary blood donors. Ind J of Med Sci. 2004;58:255-7.

Ahmud MU, Begum HA, Hossain T, Chokrabraty P. Incidence of common transfusion transmitted diseases among blood donors. JAFMC Bangladesh. 2009;4-6.