DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20181292

Correlation of histologic grade of breast carcinoma with hormone receptor status in a tertiary care hospital

Greeshma Ann George, Archana Sachin Bembde, Neha Borde, Chandrashekhar Bhale

Abstract


Background: Breast cancer is one of the most common malignancies affecting the female population worldwide. Prognosis and management of breast cancer are influenced by variables such as stage, grade, hormone receptor status of oestrogen(ER), progesterone(PR) and Human epidermal growth factor receptor2 (HER2/neu) overexpression. Aim to correlate grade of tumour with ER, PR and HER2/neu receptor status of breast carcinoma.

Methods: A prospective study was done in Pathology department, MGM Medical College and Hospital, Aurangabad, Maharashtra for one year. Out of 65 cases studied, 28 cases were biopsy and 37 cases were modified radical mastectomy specimens. All samples were subjected for routine histological examination and immunohistochemical analysis.

Results: Age of patients ranged from 30 to 82 years; 60% of tumours were right sided; 46% were involving upper outer quadrant; 58% were radiologically BI-RADS 4; 46% tumours were histopathologically grade 2 and 90% were invasive breast carcinoma, not otherwise specified. By immunohistochemistry, 60% were ER/PRpositive, 9% HER2/neu positive, 26% triple negative and 5% HER2/neu equivocal. In our study, out of 13 grade 1 tumours, 100% were ER/PRpositive and HER2/neu negative; thus an inverse relationship was found between HER2/neu and ER/PR receptors. Also 70% of triple negative tumours were grade 3 which have an aggressive behaviour compared to other subtypes and were common in premenopausal women.

Conclusions: Assessment of hormone receptors for clinical management of breast cancer patients is strongly advocated to provide prognostic information and best therapeutic options. A significant correlation was observed between hormonal receptor status and the grade of tumour.


Keywords


Breast carcinoma, Oestrogen receptor, Progesterone receptor, Triple negative and HER2/neu

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References


Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. Globocan 2012 v1.1, Cancer incidence and mortality worldwide: IARC cancerbase no. 11. Lyon, France: International agency for western cancer; 2014. Available at http://globocan.iarch.fr.

Azizun-Nisa BY, Raza F, Kayani N. Comparison of ER, PR and HER-2/neu (C-erb B 2) reactivity pattern with histologic grade, tumor size and lymph node status in breast cancer. Asian Pac J Cancer Prev. 2008;9(4):553-6.

Vinay Kumar V, Abbas AK, Fausto N. Robbins and Cotran Pathologic Basis of Disease. 7th Eds. Philadelphia, Elsevier;2007:1136-37.

Suvarchala Sb, Nageshwararao R. Carcinoma Breast-Histopathological and hormone receptors correlation. J Biosci Tech. 2011:2(4);340-48.

Hashmi AA, Edhi MM, Naqvi H, Faridi N, Khurshid A, Khan M. Clinicopathologic features of triple negative breast cancers: an experience from Pakistan. Diagnostic pathology. 2014;9(1):43.

Almasri NM, Al Hamad M. Immunohistochemical evaluation of human epidermal growth factor receptor 2 and estrogen and progesterone receptors in breast carcinoma in Jordan. Breast cancer research. 2005;7(5):R598.

Sandhu DS, Sandhu S, Karwasra RK, Marwah S. Profile of breast cancer patients at a tertiary care hospital in north India. Indian J Cancer. 2010;47:16-22.

Ambroise M, Ghosh M, Mallikarjuna VS, Kurian A. Immunohistochemical Profile of Breast cancer patients in a tertiary care hospital in South India. Asian Pacific J Cancer Prev. 2011;12:625-9.

Ghosh J, Gupta S, Desai S, Shet T, Radhakrishnan S, Suryavanshi P, et al. Estrogen, progesterone and HER2 receptor expression in breast tumors of patients, and their usage of HER2-targeted therapy, in a tertiary care centre in India. Indian J Cancer. 2011;48:391-6.

Adedayo AO, Engel JM, Greenlee RT, Mukesh BN. Breast cancer Subtypes Based on ER/PR and Her2 expression: Comparison of clinicopathologic Features and Survival. Clin Med Res. 2009;7:4-13.

Sharif MA, Mamoon N, Mushtaq S, Khadim MT, Jamal S. Steroid Hormone Receptor Association with Prognostic Markers in Breast Carcinoma in Northern Pakistan. J Coll Physicians Surg Pak. 2010;20:181-85.

Geethamala K, Srinivasa Murthy V, BR Vani and Sudha Rao. Histopathological grade versus hormone receptor status in breast carcinoma-Treasure the past. Inter J Biomed Res. 2015;6(07);466-471.