DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20181295

Clinical and histopathological correlation of breast lesions

Kavita Sharma, S. P. Vyas, Subhash Dhayal

Abstract


Background: To study the histopathological features of neoplastic and non neoplastic lesions of breast.  To correlate the pathological findings with clinical parameters.

Methods: We have studied total 170 cases of breast lesions over a period of two years in our institute. The specimens were received in histopathology section of our department. Detailed gross examination of specimens was done followed by fixation, thorough sampling, and tissue processing. The different lesions were studied by histopathological examination and analysed. Neoplastic lesions were classified according to the WHO classification.

Results: Out of the 170 cases, 128 cases had neoplastic lesions and 41 cases had non-neoplastic lesions, and one case had coexistent neoplastic and nonneoplastic lesions. Out of the total 129 cases with neoplastic lesions, 76 cases had benign breast tumors, 51 cases had malignant breast tumors, and 2 cases had precursor lesions. Fibroadenoma was the most common benign tumour with 62 cases. Invasive carcinoma no special type was the most common malignant tumour with 43 cases. Special subtypes of invasive carcinoma found in our study were mucinous carcinoma (2 case). The most common nonneoplastic lesion was mastitis with 12 cases, followed by duct ectasia and fibrocystic change. There were 6 cases of gynaecomastia. All the tumors involved upper outer quadrant most frequently. The benign tumors were most frequent in second, third and fourth decades, malignant tumours were seen beyond 4th decade. The nonneoplastic lesions were common in 4th decade.

Conclusions: Histopathological study is important in the management of breast lesions.

Keywords


Neoplastic, Non neoplastic

Full Text:

PDF

References


Bancroft JD, Gamble M. Theory and Practice of Histopathological techniques. 5th edi. Elsevier. 2002:125-200.

Sulhyan KR, Anvikar AR, Mujawar IM, Tiwari H. Histopathological study of breast lesions. IJMSR Rev. 2017;5(01):32-41.

Oluwole, Soji F, Harold P. Analysis of benign breast disease in blacks. Am J Surg. 1979;137(6):786-9.

Raju GC, Jankey N, Narayansingh V. Breast disease in young west Indian women: an analysis of 1051 cases. Postgrad Med J. 1985;61(721):977-8.

Haque R, Tyagi SP, Khan MH, Gahlaut YVS. Breast lesions, A clinicopathological study of 200 cases of breast lumps. Ind J Surg. 1980;42:419-25.

Azzopardi JG, Chepick OF, Hartmann WH, Jafarey NA. The world health organization. Histological typing of breast tumors. Am J Clin Pathol. 1982;78:806-16.

Shabtai M, Saavedra-Malinger P, Shabtai EL, Rosin D, Kuriansky J, Ravid-Magido M et al. Fibroadenoma of the breast: Analysis of associated pathological entities-A different risk marker in different age groups for concurrent breast cancer. IMAJ. 2001:3813-7.

Sklair-Levy M, Sella T, Alweiss T, Cracium I, Libson E, Mally B. Incidence and management of complex fibroadenoma AJR Am J Roentgenol. 2008;190(1):214-8.

Varghas MP, Merino MJ Infarcted myxoid fibroadenoma following fine needle aspiration. Arch Pathol Lab Med. 1996;120(11):1069-71.

Skenderi F, Krakonja F, Vranic S. Infarcted fibroadenoma of the breast: report of two new cases with review of literature Diagn Pathol. 2013;8:38.

Mudholkar VG, Kawade SB, Mashal SN. Histopathological study of neoplastic lesions of breast. Ind Med Gazette. 2012:353-64.

Osteen RT, Karnell LH. The national cancer data base report on breast cancer. Cancer. 1994;73(7):1994-2000.

Njeze GE. Breast lumps: A 21-year single centre clinical and histological analysis, Nigerian J Surg. 2014;20(1):38-41.

Truong PT, Berthelet E, Lee J, Kader H, Olivotto I A. The prognostic significance of the percentage of positive /dissected axillary lymph nodes in breast cancer recurrence and survival in patients with one to three positive axillary lymph nodes. Cancer. 2005;103(10):2006-14.

Yoshihara E, Smeets A, Laenen A, Reynders A, Soens J, Van Ongeval C, et al. Predictors of axillary lymph node metastases in early breast cancer and their applicability in clinical practice. Breast. 2013;22(3):357-61.

Yip CH, Smith RA, Anderson BO, Miller AB, Thomas DB, Ang ES, et al. a breast health global initiative early detection panel. Cancer.2008;113(8):2244-56.

Siddiqui MS, Kayani N, Gill MS, Pervez S, Aziz SA, Muzaffar S, et al. Breast diseases: a histopathological analysis of 3279 cases at tertiary care centre in Pakistan . JPMA. 2003:53-94.

Olu-Eddo AN, Ugiagbe EE. Benign breast lesions in an African population: A 25-year histopathological review of 1864 cases. Niger Med J. 2011;52(4):211-6.

Munjal K, Jain VK, Agrawal A, Bandi PK. Co existing tubercular axillary lymphadenitis with carcinoma breast can falsely overstage the disease-case series. Ind J Tuber. 2010;57:104-7.

Dave R, Dhruva G, Agravat A. Breast cancer and breast tuberculosis: a rare coexistence. Ind J Res Med. 2014;3(1):108-10.

Johnson RE, Murad MH. Gynecomastia: pathophysiology, evaluation, and management. Mayo Clin Proc. 2009;84(11):1010-5.

Lee AHS, Gillett CE, Ryder K, Fentiman IS, Miles DW. Millis RR. Different patterns of inflammation and prognosis in invasive carcinoma of breast. Histopathology. 2006;48(6):692-701.