DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20181299

Descriptive study of gastrointestinal manifestations in HIV/AIDS

Varghese Koshy, George Koshy, Vandana Gangadharan

Abstract


Background: Acquired Immunodeficiency Syndrome (AIDS) was first recognized in 1981 as a clinical syndrome consisting of opportunistic infections and /or neoplasia associated with uneplained immunodeficiency. The gastrointestinal tract is one of the most common sites of clinical affection of AIDS and all levels from the oral cavity to the anus are frequently involved.

Methods: A cohort of 70 HIV positive patients, admitted in a tertiary level referral hospital, were studied for symptoms of gastrointestinal disease and patients with clinical or investigative findings of gastrointestinal disease were clinically examined and then subjected to further relevant investigations.

Results: The prevalence of GI menifestations in this cohort was 71.4%. The mean age of the study population was 36 years. Amongst frequency of GI manifestations, diarrhoea was found in 26 patients (52%), of whom 77% (20 out of 26) had diarrhoea lasting longer than one month and amongst the patients with oral ulcers, oral candidiasis was the most common oral manifestation, present in 87% of them. Cryptosporidium was the most common organism isolated from the stool samples.

Conclusions: The most common presenting complaints were oral ulcers and chronic diarrhoea amongst the cohort examined in this study.


Keywords


Diarrhoea, GI Manifestations, HIV, Oral manifestations

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References


Gazzard BG. HIV disease and the gastroenterologist. Gut. 1988;29:1497-1505.

Royce RA, Luckmann RS, Fusaro RE, Winkelstein W. The natural history of HIV-1 infection: staging classifications of disease. AIDS. 1991;5:355-64.

Klein RS, Harris CA, Small CB, Moll B, Lesser M, Friedland GH. Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. New Eng J Medicine. 1984;311(6):354-8.

Bonacini M, Laine LA. Oesophageal disease in patients with AIDS: diagnosis and treatment. Gastrointest Endosc Clin N Am. 1998;8:811-23.

Herzlich BC, Schaiano TD, Moussa Z, Zimbalist E, Nawabi I. Decreased intrinsic factor secretion in AIDS: capacity and Vitamin B12 malabsorption. Am J Gastroenterol. 1992;87:1781.

Rabeneck L, Gyorkey F, Genta RM, Gyorkey P, Foote LW, Risser JM. The role of microsporidia in the pathogenesis of HIV-related chronic diarrhea. Annals Internal Medicine. 1993;119(9):895-9.

Rathi PM, Amarapurakar DN, Parikh SS, Joshi J, Koppikar GV, Amarapurkar AD, et al. Impact of humarn immunodeficiency virus infection on abdominal tuberculosis in Western India. J Clin Gastroenterol. 1997;24(1):43-8.

Fee MJ, Oo MM, Gabayan AE, Radin DR, Barnes PF. Abdominal tuberculosis in patients infected with the human immunodeficeiency virus. Clin Infect Dis. 1995;20(4):938-44.

Jones JM, Miller JN, George WL, Microbiological and biochemical characterization of spirochaetes isolated from the feces of homosexual men. J Clin Microbiol. 1986;24:1071.

Khotari K, Goyal S. Clinical profile of AIDS. J Assoc Physicians Ind. 2001;49:435-8.

Greenspan D, Greenspan JS. HIV-related oral disease. Lancet. 1996;348:729-33.

Weinert M, Grimes RM, Lynch DP. Oral manifestations of HIV infection. Ann Intern Med. 1996;125:485-96.

Lifson AR, Hilton JF, Westenhouse JL, Canchola AJ, Samuel MC, Katz MH, et al. Time from HIV seroconversion to oral candidiasis or hairy leukoplakia among homosexual and bisexual men enrolled in three prospective cohorts. AIDS. 1994;8(1):73-9.

Wilcox CM. Oesophageal disease in the acquired immunodeficiency syndrome: etiolgy, diagnosis and management. Am J Med. 1992;92:412.

Sharpstone D, Gazzard B. Gastrointestinal manifestations of HIV infection. Lancet. 1996;348(9024):379-83.

Goodgame RW. Understanding intestinal spore-forming protozoa: cryptosporidia, microsporidia, isospora, and cyclospora. Annals Inter Med. 1996;124(4):429-41.