DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20180967

A comparative study of parasympathetic function tests during different phases of menstrual cycle in young healthy females

Shaily Verma, Prashant Khuraiya, Rajni Soni

Abstract


Background: The hormonal fluctuations that occur during normal menstrual cycle has profound influence on autonomic functions. This influence on autonomic nervous system may affect cardiovagal control. The aim of the study is to find out the variation of Parasympathetic function tests during different phases of menstrual cycle in young healthy females.

Methods: The present study was carried out on 50 healthy female subjects with normal menstrual cycles between the ages of 18 to 25 years. Various non-invasive parasympathetic function tests during different phases of menstrual cycle were performed that include Resting heart rate (RHR), Heart rate variation during deep breathing (E:I Ratio), Heart rate response to standing (30:15 Ratio), Heart rate response to Valsalva maneuver (Valsalva Ratio). The results were analysed using ANOVA and student’s paired-t tests.

Results: During the menstrual cycle, we found varied heart rate response with higher values towards the luteal phase, when compared to the follicular phase and the menstrual phase. There was a statistically significant difference in the heart rate parameters like resting heart rate, 30:15 ratio, valsalva ratio and E:I ratio during the three phases of menstrual cycle.

Conclusions: The study concludes that there was statistically significant heart rate variability during three phases of the menstrual cycle, as observed by the increased sympathetic discharge in the luteal phase compared to the increased parasympathetic discharge in the follicular phase. The results of our study have emphasized the complexity of the relationship between ovarian steroids and various hemodynamic regulatory systems.


Keywords


Heart rate, Menstrual cycle, Parasympathetic function tests

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References


Agarwal G, Kumar R, Kumar J, Bijaraniya K. Study of Sympathetic Function Tests during Different Phases of Menstrual Cycle. Sch J App Med Sci. 2015;3(3F):1462-6.

Farage MA, Neill S, MacLean AB. Physiological changes associated with the menstrual cycle: a review. Obstet Gynecol Surv. 2009;64(1):58-72.

Perrot-Applanat M. Estrogen receptors in the cardiovascular system. Steroids. 1996;61:212-5.

Mehta V, Chakrabarty AS. Autonomic functions during different phases of menstrual cycle. Indian J Physiol Pharmacol. 1993;37(1):56-8.

Palmero F, Choliz M. Resting heart rate (HR) in women with and without premenstrual symptoms (PMS). J Behav Med. 1991;14(2):125-39.

Yildirir A, Kabakci G, Akgul E, Tokgozoglu L, Oto A. Effects of menstrual cycle on cardiac autonomic innervation as assessed by heart rate variability. Ann Noninvsive Electrocardiol. 2002;7(1):60-3.

Minson CT, Halliwill JR, Young TM, Joyner MJ. Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation. 2000;101(8):862-8.

Parlewar RK, Venkatraman B. Parasympathetic Functions Study during Different Phases of Menstrual Cycle. IOSR J Dental Med Sci. 2015;14(5):85-8.

Kavitha C, Jamuna BL, Vijayakumar GS. Cardiac chronotropism and sympathovagal balance in young women of reproductive age. Int J Biol Med Res. 2012;3(4):2313-8.

Barrett KE, Barman SM, Boitano S, Brooks HL. Ganong’s Review of Medical Physiology. 25th ed. McGraw Hill Education. 2016;527.

Nilekar AN, Patil VV, Kulkarni S, Vatve M. Autonomic function tests during pre and post menstrual phases in young women. Pravara Med Rev. 2011;3(2):24-30.

Pal GK, Pal P. Text book of practical physiology. 3rd ed. Universities press. 2010:282-289.

Fuenmayor AJ, Ramirez L, Fuenmayor AM. Left ventricular function and autonomic nervous system balance during two different stages of the menstrual cycle. Inter J Cardiol. 2000;72(3):243-6.

Choudhury R, Jahan N, Sultana N, Akter R, Khanum AA. Parasympathetic nerve function status during different phases of menstrual cycle in healthy young women. J Bangladesh Soc Physiol. 2011;6(2):100-7.

O'Brien IA, O'Hare P, Corrall RJ. Heart rate variability in healthy subjects: effect of age and the derivation of normal ranges for tests of autonomic function. Br Heart J. 1986;55(4):348-54.