A morphology and histological study of placenta in normal and diabetic pregnancies
DOI:
https://doi.org/10.18203/2320-6012.ijrms20181778Keywords:
Diameter, Gestational diabetes, Histology, Morphology, Pregnancies, PlacentaAbstract
Background: The placenta is a vital organ for developing foetus, and it is also the most accessible organ of human body, pregnancy in a diabetogenic state by virtue of various physiological changes which cause insulin resistance. In normal pregnancy, glucose tolerance decreases by third trimester, though plasma levels of insulin increase. Aim was to study comparison of placenta of normal pregnancy with placenta of diabetic pregnancy and it the possible outcome of pregnancy.
Methods: The present study was case-control and conducted on cases of 50 Specimens of placenta with intact umbilical cord were collected from the Department of Obstetrics and Gynecology.
Results: Variation in the shape and weight of the placenta were observed. The mean placenta weight in control group was found to be 452.80 grams with standard deviation 140.93 grams while in the case group; it was 406.00 grams with standard deviation of 210.31 grams. The random blood sugar of mother in control group was significantly higher than cases (t=2.91, p<0.01).
Conclusions: The present study shown that there was a tendency of increase in placental weight and weight of new born in complicated pregnancies as compared to the normal pregnancies. This indicated the earlier diagnosis and strict to treatment plan in diabetic pregnancies.
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Saha S, Biswas S, Mitra D, Adhikari A, Saha C. Histologic and morphometric study of human placenta in gestational diabetes mellitus. Ital J Anat Embryol. 2014 Jan 1;119(1):1.
Evers IM. Placental pathology in women with type 1 diabetes and in a control group with normal and large-for-gestational-age infants. Placenta. J of Obst and Gynaec. 2003;24:819-25.
Van Katwijk C, Peeters LL. Clinical aspects of pregnancy after the age of 35 years: a review of the literature. Human reproduction update. 1998 Mar 1;4(2):185-94.
Saha S, Biswas S, Mitra D, Adhikari A, Saha C. Histologic and morphometric study of human placenta in gestational diabetes mellitus. Ital J Anat Embryol. 2014 Jan 1;119(1):1.
Lao TT, Lee CP, Wong WM. Placental weight to birthweight ratio is increased in mild gestational glucose intolerance. Placenta. 1997 Mar 1;18(2-3):227-30.
Saha S, Biswas S, Mitra D, Adhikari A, Saha C. Histologic and morphometric study of human placenta in gestational diabetes mellitus. Ital J Anat Embryol. 2014 Jan 1;119(1):1.
Thomson AM, Billewicz WZ, Hytten FE. The weight of the placenta in relation to birthweight. BJOG: An International J Obstetrics & Gynaecology. 1969 Oct 1;76(10):865-72.
De Falco S. The discovery of placenta growth factor and its biological activity. Experimental & molecular medicine. 2012 Jan;44(1):1.
Crowther CA, Hiller JE, Moss JR, McPhee AJ, Jeffries WS, Robinson JS. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med. 2005 Jun 16;352(24):2477-86.
Platt MJ, Stanisstreet M, Casson IF, Howard CV, Walkinshaw S, Pennycook S, et al. St Vincent’s Declaration 10 years on: outcomes of diabetic pregnancies. Diabetic Medicine. 2002 Mar 1;19(3):216-20.
Evers IM. Placental pathology in women with type 1 diabetes and in a control group with normal and large-for-gestational-age infants. Placenta. J of Obst and Gynaec. 2003;24:819-25.
Udainia A, Jain ML. Morphological study of placenta in pregnancy induced hypertension with its clinical relevance. J Anat Soc India. 2001;50(1):24-7.
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