A case control study on s. uric acid and s. creatinine level in pre-eclampsia patients of a tertiary care hospital in Jabalpur district of Central India

Bhagwan S. Yadav; Sharad K. Jain; Neelam A. Toppo; Chanchlesh Dehariya

doi:10.18203/2320-6012.ijrms20181451

Authors

Bhagwan S. Yadav Department of Pathology, NSCB Medical College Jabalpur, Madhya Pradesh, India
Sharad K. Jain Department of Pathology, NSCB Medical College Jabalpur, Madhya Pradesh, India
Neelam A. Toppo Department of Community Medicine, NSCB Medical College Jabalpur, Madhya Pradesh, India
Chanchlesh Dehariya Department of Pathology, NSCB Medical College Jabalpur, Madhya Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20181451

Keywords:

Pre-eclampsia, Serum reatinine, Urice acid

Abstract

Background: Pre-eclampsia is a multisystem disorder of pregnancy which is characterized by hypertension with proteinuria after 20 weeks of gestation in previously normotensive and non proteinuric pregnant women. Pre-eclampsia associated with intrauterine growth retardation, preterm birth, maternal and perinatal death. Serum creatinine and uric acid has been shown to play a significant role in the pathogenesis of the disease and often precede clinical manifestations. This study compares the serum creatinine and uric acid in pre -eclampsia case and normal pregnant women and to assess its role in pre-eclampsia.

Methods: 158 patients of which 79 pre-eclampsia (cases) and 79 (controls) were selected randomly and were matched with their gestational age in patient who Attending ANC clinic at Department of Obstretics and Gynecology in March 2016 to August 2017. Lipid profile was estimated by the Randox imola is a compact fully automated clinical chemistry analyser.

Results: Authors observed that pre-eclampsia is more common in young age pregnant women with low socioeconomic status with strenuous activities. The mean age was 24.51±3.707 years. The mean serum creatinine and urice acid value is analysed in pre-eclampia cases and compared with control group showing significantly increase (p<0.0001).

Conclusions: Young age, nullyparity, low socio economic status specially labour occupation, with derangment of Serum creatinine in pregnant women were found to be more prone to develop pre-eclampsia. Proper history tacking, examination and estimation of serum creatinine and uric acid may be helpful for early diagnosis and management of pre–eclampsia in order to prevent fetal and maternal complications especially in nulliparous women.

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References

Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;365(9461):785-99.

Gohil JT, Patel PK, Gupta P. Lipid profile in patients of pre-eclampsia. Journal of Obstetrics and Gynaecology of India. 2011;61(4):399-403.

Duley L. Maternal mortality associated with hypertensive disorders of pregnancy in Africa, Asia, Latin America and the Caribbean. Br J Obstet Gynaecol. 1992;99:547-53.

Fernando A, Shrish ND, Amarnath GB. Hypertensive disorders of pregnancy. Practical guide to high risk pregnancy and delivery; 3rd Edition; 2008:398.

Saleh F, Shukar-ud-Din S, Soomro N. Serum uric acid as predictor model for preeclampsia. Pak J Surg. 2010;26(3):246-51.

Epstein FH, Karumanchi SA. Pregnancy and the Kidney. Nephrology Rounds 2005.Nov;3(9).

Zibaeenazhad MJ, Ghodsi M, Arab P, Gholzom N. The prevalence of hypertensive disorders of pregnancy in Shiraz, Southern Iran. Iranian Cardiovascular Research Journal. 2010;4:169-72.

Sheraz S, Shahzad S, Boota M. Eclampsia. Professional Medical Journal. 2006;13(1):27-31.

Kumar R, Gandhi S, Rao V. Socio-Demographic and Other Risk Factors of Pre Eclampsia at a Tertiary Care Hospital, Karnataka: Case Control Study. Journal of Clinical and Diagnostic Research. 2014;8(9):1-4.

Duckitt K, Harrington D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. Bmj. 2005 Mar 10;330(7491):565.

Walker JJ. Severe pre-eclampsia and eclampsia. Baillieres Best Pract Res Clin Obstet Gynaecol. 2000;14(1):57-71.

Cunningham GF, Leveno KJ, Bloom SL. William’s obstetrics. 23rd Ed. Cambridge university press; 2010:706-747.

Abubakar A, Dikko A, Sufiyan MB, Salihu A, Rabiu A. Association between Maternal Socio–economic Status, Polygamy and Risk of Pre eclampsia in Rural Areas of Northern Nigeria Journal of Family and Reproductive Health. 2010;4(1):47-52.

Dlamini NJ. Factors associated with pre–eclampsia and quality care of affected teenagers during labor within health region H. in Kwa–Zulu Natal. 1997;20:16-22.

Gudmundsson S, Björgvinsdóttir L, Molin J, Gunnarsson G, Marsal K. Socioeconomic status and perinatal outcome according to residence area in the city of Malmö. Acta obstetricia et gynecologica Scandinavica. 1997 Apr 1;76(4):318-23.

Niraula A, Lamsal M, Majhi S, Khan SA, Pritha B. Significance of Serum Uric Acid in Pregnancy Induced Hypertension. Journal of the national medical association. 2017;109(3):198-202.

Sharma DK. International Journal of Clinical Biochemistry and Research. January-March 2015;2(1):18-21.

Bainbridge SA, Roberts JM. Uric Acid as a Pathogenic Factor in Pre-eclampsia. Placenta. 2008;(A):S67-72.

Many A, Hubel CA, Fisher SJ, Roberts JM, Zhou Y. Invasive cytotrophoblasts manifest evidence of oxidative stress in preeclampsia. Am J Pathol. 2000;156:321-31.

Bainbridge SA, Von Versen-Hoynck F, Roberts JM. Uric acid inhibits placental system. A amino acid uptake. Placenta. 2009;30:195-200.

Israa AMJ. Estimation of uric acid ,urea, creatinine and creatinine clearance in the serum of pre eclamptic women. Kerbala Journal of Pharmaceutical Sciences. 2012;4:183-9.

Patil S, Jyothi A, Babu A, Goud GK. A study on Liver function tests and Renal function tests in Preeclampsia. International Journal of Biomedical Research. 2016;7(10):713-7.

Salako BL, Odukogbe ATA, Olayemi O, Adedapo KS, Aimakhu CO, Alu FE, et al. serum albumin, creatinine, uric acid and hypertensive disorders of pregnancy. East African Medical Journal. 2003;80(8):424-8.

Shah DM. Role of the renin-angiotensin system in the pathogenesis of pre-eclampsia. American Journal of Physiology - Renal Physiology. 2005;288(4):614-25.

Irani RA, Xia Y. Renin angiotensin signaling in normal pregnancy and pre-eclampsia. Seminars in Nephrology. 2011;31(1):47-58.

Redman CW, Beilin LJ, Bonnar J. Renal function in pre-eclampsia J Clin Path. 2000;29(10):91-4.

Alexander BT, Bennett WA, Khalil RA, Granger JP. Pre-eclampsia: Linking Placental Ischemia with Cardiovascular-Renal Dysfunction. News Physiol. Sci. 2001;16:282-6.

Bolte AC, Geijna HP, Dekker GA. Pathophysiology of pre-eclampsia and the role of serotonin. European Journal of Obstetrics and Gynaecology and Reproductive Biology. 2001;95:12-21.

Davison JM, Homuth V, Jeyabalan A, Conrad KP, Karumanch SA, Quaggin S, et al. New Aspects in the Pathophysiology of Pre-eclampsia. Am Soc Nephrol. 2004;15:2440-8.

Reynolds C, Mabie WC, Sibai BM. Hypertensive state of Pregnancy, In: Decherney AH, Nathan L, Current obstetrics and Gynecology, 9th Ed, McGraw-Hill, USA; 2003:338-345.

Moldenhauer, JS. Hypertensive Disorder of Pregnancy In: Scott J, Gibbes RS, Karlen BY, Hanry AF, Danforth’s obstetrics and Gynecology, 9th Ed, Lippincott Williams andWilkings, Philadelphia; 2003:257-260.