DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20184061

Occurrence of neurocysticercosis in patients presenting with seizure and its serological evaluation

Khushbu Malhotra, Mandeep Singh, Siddhant Sudanshu, Vinod Kumar, Utkarsh Sharma

Abstract


Background: Aims and objectives was to diagnose neurocysticercosis among the patient admitted with seizure in Pediatric Department of TMMRC and to correlate the serological and radiological findings.

Methods: A total of 100 patients presenting with recent onset seizures were recruited from Pediatric department of a local major tertiary care teaching hospital during the period 2016-2017. Brain imaging was performed in all the above cases. Serological assessment was done using ELISA kit. Diagnosis of neurrocysticercois was done using Del Brutto’s criteria.

Results: The recruited patients presented with generalized, simple partial, and focal seizures (68%, 21% and 11% respectively). NCC was diagnosed in 37 of 100 (37.0%) seizure cases based on imaging characteristics. There were 13% cases in whom, MRI showed calcified NCC/granuloma suggestive of NCC. In 24% cases, scolex suggestive of NCC was seen. A total of 15 (15%) cases were seropositive for Taenia. Using Del Brutto criteria, a total of 23% cases were diagnosed as probable NCC and 15% as definite neurocysticercosis. A total of 62% cases were confirmed as not having neurocysticercosis.

Conclusions: The findings of present study showed that neurocysticercosis still is a major diagnosis among children presenting with seizure from this endemic area. Neuroimaging was a useful tool in diagnosis and characterisation of NCC than serological tool. The study highlighted the need to create awareness regarding maintenance of hygiene and cleanliness.


Keywords


Del Brutt, Neurocysticercosis, Radiological evaluation, Seizure, Serology

Full Text:

PDF

References


McAbee GN, Wark JE. A practical approach to uncomplicated seizures in children. American Family Physician. 2000;62(5):1109-16.

Stafstrom CE. Neonatal seizures. Pediatrics in Review. 1995;16(7):248-56.

Idro R, Gwer S, Kahindi M, Gatakaa H, Kazungu T, Ndiritu M, et al. The incidence, aetiology and outcome of acute seizures in children admitted to a rural Kenyan district hospital. BMC pediatrics. 2008 Dec;8(1):5.

Murthy JMK, Yangala R. Acute symptomatic seizures-incidence and etiological spectrum: a hospital-based study from South India. Seizure. 1999;8(3):162-5.

Rayamajhi A, Singh R, Prasad R, Khanal B, Singhi S. Study of Japanese encephalitis and other viral encephalitis in Nepali children. Pediatrics Inter Offi J Japan Pedia Soci. 2007;49(6):978-84.

Huang CC, Chang YC, Wang ST. Acute symptomatic seizure disorders in young children - a population study in southern Taiwan. Epilepsia 1998;39(9):960-4.

Basu S, Ramchandran U, Thapliyal A. Clinical profile and outcome of pediatric neurocysticercosis: A study from Western Nepal. J Pediatric Neurol. 2007;5(1):45-52.

Pappala BCS, Indugula JP, Talabhatula SK, Kolli RS, Shrivastva AK, Sahu PS. Diagnosis of neurocysticercosis among patients with seizures in northern coastal districts of Andhra Pradesh, India. Asian Pac J Trop Biomed. 2016;6(11):903-8.

Sahu PS, Seepana J, Padela S, Sahu AK, Subbarayudu S, Barua A. Neurocysticercosis in children presenting with afebrile seizure: clinical profile, imaging and serodiagnosis. Rev Inst Med Trop. 2014;56(3):253-8.

Rao KS, Adhikari S, Gauchan E, Sathian B, B. K. G, Basnet S, et al. Time trend of neurocysticercosis in children with seizures in a tertiary hospital of western Nepal. PLoS Negl Trop Dis. 2017;11(5):e0005605.

Chaudhary N, Gupta MM, Shrestha S, Pathak S, Kurmi OP, Bhatia BD, et al. Clinicodemographic Profile of Children with Seizures in a Tertiary Care Hospital: A Cross-Sectional Observational Study. Neurol Res Inter. 2017;2017:1524548.

Pozo-García MP, Campos-Olazábal P, Burneo J. Neurocisticercosis en una población pediátrica en Lima: analisis epidemiológicoy clínico. Rev Neurol. 2003;36:205-8.

White AC Jr. Neurocysticercosis: a major cause of neurological disease worldwide. Clin infect Dis. 1997;29:101-13.

Román G, Sotelo J, Del Brutto O, Flisser A, Dumas M, Wadia N, et al. A proposal to declare Neurocysticercosis an International reportable disease. Bulletin of World Health Organisation. 2000;78(3):399-406.

Singhi S, Singhi P. Clinical profile and etiology of partial seizures in North Indian infants and children. J Epilepsy. 1997;25:147-62.

Baird RA, Zunt JR, Halperin JJ, Gronseth G, Roos KL, Wiebe S. Evidence-based guideline: treatment of parenchymal neurocysticercosis. Report of the guideline development subcommittee of the American academy of neurology. Neurol. 2013;80(15):1424-9.

Del Brutto OH. Diagnostic criteria for neurocysticercosis, revisited. Pathog Glob Health. 2012;106(5):299-30.

Kumar A, Mandal A, Sinha S, Singh A, Das RR. Prevalence, response to cysticidal therapy, and risk factors for persistent seizure in Indian children with neurocysticercosis. Int J Pediatrics. 2017:1-6.

Bhattacharjee S, Biswas P, Mondal T. Clinical profile and follow-up of 51 pediatric neurocysticercosis cases: A study from Eastern India. Annals Ind Aca Neurol. 2013;16(4):549-55.

Pandit MS, Sharma JN, Choudhary A, Vijay P. Study of clinical and radiological profile of children with neurocysticercosis. Int J Contemp Pediatr. 2017;4(5):1727-32.

Yanagida T, Sako Y, Nakao M, Nakaya K, Ito A. Taeniasis and cysticercosis due to Taenia solium in Japan. Parasites Vectors. 2012;5:18.