DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20182306

An analysis of surgically treated cutaneous malignancies in central India

Amar Jain, Sanjay Desai, Zeeshanuddin Ahmad, Deepak Agrawal, Nikhil Mehta

Abstract


Background: Cutaneous malignancies constitute one of the most common human malignancies. Annually, more than 400,000 people are diagnosed to have skin cancer. The skin cancers are classified into melanomas and non-melanoma skin cancers (NMSC). In India, skin cancers constitute about 1-2% of all the diagnosed cancers. The present study was undertaken on 41 patients presented to tertiary health centre to measure the frequency of cutaneous malignancies in our set up, analyse the demographic profile of the patients, assess the associated morbidity and mortality, formulate the treatment protocols and collect actionable evidence base for evolving useful strategies to address this emerging public health issue.

Methods: Present study was carried out in the Department of surgical oncology, Sri Aurobindo Institute of Medical Sciences (SAIMS), Central India during the period from Jan 2015 to Dec 2017. The patients included in this study fulfilled the inclusion criteria which was first who presented with cutaneous malignancy confirmed by histopathology and surgical intervention.

Results: Out of a total of 41 patients with various cutaneous malignancies, 53.7% (n=22) were males while 46.3 % (n=19) were females. The mean age was 53.92 years. There were 24 cases of SCC, 4 cases of BCC, 5 cases of malignant melanoma, two cases of malignant fibrous histiocytoma, two cases of sebaceous and one case each of dermatofibrosarcoma protuberans, epithelioma, capillary haemangioma and poorly differentiated carcinoma respectively. Face was the most frequent site of involvement (n=17), followed by trunk (n=6), scalp (n=5), lower limb (n=5), genital (n=4), upper limb (n=3) and neck (n=1).

Conclusions: Cutaneous malignancies are not uncommon in our set up. In our set up, SCC constitutes the leading type. Painless skin lesion of a relatively long duration is the usual presenting feature. There is intense need of mass awareness and to impart knowledge about the medical and socioeconomic implications of this emerging health issue. This will not only help to prevent the avoidable causes but also prompt early medical consultation in case an individual develops such skin lesions.

 


Keywords


Cutaneous malignancy, Skin cancer

Full Text:

PDF

References


Kim KH, Geronemus RG. Mohs micrographic surgery. In: Thorne CH, Beasley RW, Aston SJ, Bartlett SP, Gurtner GC, Spear SL, eds. Grabb and Smith’s Plastic surgery. 6th Ed. Philadelphia: Lippincott Williams and Wilkins; 2007:115-9.

Najjar T. Cutaneous Squamous Cell Carcinoma. Available at: www.emedicine.com/plastic/topic455. htm. Cited 2009 March 22.

Trakatelli M, Ulrich C, del Marmol V, Euvard S, Stockfleth E, Abeni D. Epidemiology of nonmelanoma skin cancer (NMSC) in Europe: accurate and comparable data are needed for effective public health monitoring and interventions. Br J Dermatol. 2007;156 Suppl 3:1-7.

Sanchez CF. The relationship between the ozone layer and skin cancer. Rev Med Chil. 2006;134(9):1185-90.

Lewis KG, Weinstock MA. Trends in Nonmelanoma Skin Cancer Mortality Rates in the United States, 1969 through 2000. J Invest Dermatol. 2007;127(10):2323-7.

Heistein JB, Acharya U. Cancer, Melanoma, Malignant. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2018. Available at: https://www.ncbi.nlm.nih.gov/books/NBK470409/.

American Cancer Society. What Are the Key Statistic About Melanoma? (Serial online) 2008 Sep 26. Available at: http://www.cancer.org /docroot/cri/content/cri_2_4_1x_wat_are_the_key_statistics_for_melanoma_50. Accessed 2009 March 22.

National Cancer Registry Programme. Indian Council of Medical Research (1990-1996) Consolidated Report of the Population Based Cancer Registries. Available at: http://www.ncdirindia.org/ncrp/Old_Reports/PBCR_Suppliment/supplement_pbcr.pdf.

Deo SV, Sidhartha H, Shukla NK, Kumar S, Kar M, Samaiya A. Surgical management of skin cancers: experience from a regional cancer centre in North India. Ind J Cancer. 2005;42(3):145-50.

Ochicha O, Edino ST, Mohamed AZ, Umar AB. Dermatological malignancies in Kano, Nigeria: a histopathological review. Annal African Med. 2004;3(4):188-91.

Talvalkar GV. Squamous cell carcinoma of skin: its incidence and etiopathogenesis in 625 cases. Ind J Cancer. 1970;7:24-33.

Schreiber MM, Shapiro SI, Berry CZ, Dahlen RF, Friedman RP; The incidence of skin cancer in southern Arizona (Tucson) Arch Dermatol. 1971;104:124-7.

Hubbell CR, Rabin VR, Mora RG; Cancer of the skin in blacks V.A review of 175 black patients with squamous cell carcinoma of the penis. J Am Acad Dermatol. 1988; 18:292-8.

Dogra D, Sharma N, Khanna N; Squamous cell carcinoma arising in lichen planus hypertrophicus. Indian J Dermatol. 1997;42:30-1.

Masood Q, Manzoor S; Squamous cell carcinoma arising from lichen simplex chronicus. Indian J Dermatol. 2000;45:90-1.

Sengupta S, Das JK, Gangopadhyay A. Multicentric squamous cell carcinoma over lesions of porokeratosis palmar is et plantar is disseminata and giant porokeratosis. Indian J Dermatol Venereol Leprol. 2005;71:414-6.

Tan PY, Ek E, Su S, Giorlando F, Dieu T. Incomplete excision of squamous cell carcinoma of the skin: a prospective observational study. Plastic Reconstructive Surg. 2007 Sep 15;120(4):910-6.

Arora A, Attwood J. Common skin cancers and their precursors. Surg Clin North Am. 2009;89:703-712.

Garcia-Zuazaga J, Olbricht SM. Cutaneous squamous cell carcinoma. Adv Dermatol. 2008;24:33-57.

Karve SJ, Feldman SR, Yentzer BA, Pearce DJ, Balkrishnan R. Imiquimod: a review of basal cell carcinoma treatments. J Drugs Dermatol. 2008;7:1044-1051.

Abreo F, Sanusi ID. Basal cell carcinoma in North American blacks. Clinical and histopathologic study of 26 patients. J Am Acad Dermatol. 1991;25:1005-1111.

Scotto J, Kofp AW, Urbach F. Non-melanoma skin cancer among Caucasians in four areas of the United States. Cancer.1974;34:1333-8.

Mamata M, Karuna R. Basal Cell carcinoma: evaluation of clinical and histologic variables. Indian J Dermatol. 2004;49:25-7.

Vargo N. Basal cell and squamous cell carcinoma. Semin Oncol Nurs. 2003;19:12-21.

Wanebo HJ, Cooper PH, Young DV. Prognostic factors in head and neck melanoma. Effect of lesion location. Cancer. 1988;62:831-7.

Doubrovsky A, De Wilt JH, Scolyer RA, McCarthy WH, Thompson JF. Sentinel node biopsy provides more accurate staging than elective lymph node dissection in patients with cutaneous melanoma. Annals Surg Oncol. 2004 Sep 1;11(9):829-36.

Kirkwood JM, Strawderman MH, Ernstoff MS, Smith TJ, Borden EC, Blum RH. Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. J Clin Oncol. 1996 Jan;14(1):7-17.

Criscione VD, Weinstock MA. Descriptive epidemiology of dermatofibrosarcoma protuberans in the United States, 1973 to 2002. J Am Acad Dermatol. 2007;56:968-73.

Taylor HB, Helwig EB. Dermatofibrosarcoma protuberans: a study of 115 cases. Cancer. 1962;15:717-25.

Kearney MM, Soule EH, Lvins JC. Malignant fibrous histiocytoma. Cancer. 1980;45:167-78.

Dasgupta T, Wilson LD, Yu JB. A retrospective review of 1349 cases of sebaceous carcinoma. Cancer. 2009;115:158-65.