A serological study of leptospirosis in Chennai


  • R. Kanimozhi Institute of Microbiology, Madras Medical College, Chennai 600003
  • R. Geetha Depatment of Biochemistry, Sri Lakshmi Narayana Institute of medical sciences, Puducherry
  • D. Anitha Depatment of Biochemistry, Sri Lakshmi Narayana Institute of medical sciences, Puducherry
  • V. . Ramesh Depatment of Biochemistry, Sri Lakshmi Narayana Institute of medical sciences, Puducherry




Leptospirosis, Macroscopic slide agglutination test


Background: Leptospirosis is a zoonotic disease of mammals caused by serovars belonging to the spirocheate Leptospira interrogans. Commonly occurs in tropical and sub tropical regions.

Methods: A total number of 2180 suspected cases were included in the study during the period April 2014 to June 2014. All the samples were subjected to macroscopic slide agglutination test (MSAT). Suspected leptospirosis cases (n=2180) in the Chennai city and its suburbs were clinically evaluated.

Results: The most common presentation involved was specific signs and symptoms including fever, myalgia and headache (99%). Fever followed by jaundice and renal failure were observed in 3.74% cases. Fever followed by chills, skin rashes, cough, vomiting were observed in 2.43% cases. About 30% of the infected people were found in the age group of above 60 years. Female (57 %) were found predominantly infected when compared to male (43 %). Out of 2180 suspected cases 534 (32%) were found infected due to leptospirosis during the summer by MSAT method. (April ’14-June’14).

Conclusions: This study shows leptospirosis found more common among female than male, probably due to occupational status of leptospirosis. Based on our study we suggest that senior age group people (age more than 60 years) are highly proven to this disease probably due to the less immunity factor.


Ratnam S, Subramanian S, Madanagopalan N, Sundarraj T, Jayanthi. Isolation of leptospires and demonstration of antibodies in human leptospirosis in Madras, India. 1983;77:455-8.

Meslin FX. Global aspects of emerging and potential zoonoses: a WHO perspective. Emerg Infect Dis. 1997;3:223-8.

Sehgal SC, Leptospirosis on the horizon. The National Medical Journal of India. 2000;13:228-30.

Levett PN. Leptospirosis, Clin. Microbiol. Rev. 2001;14:296-326.

Speelman P, Hartskeerl R. Leptospirosis. In: Fauci, Braunwald, Kasper, editors. Harrison's Principles of Internal Medicine. 17th ed. McGrawHill. 2008:1048-51.

Vijayachari P, Sugunan AP, Shriram AN. Leptospirosis: an emerging global public health problem. J Biosci. 2008;33:557-69.

World Health Organization, Prevention and Intervention in Human Leptospirosis, Guidance for Diagnosis, Surveillance and Control, International Leptospirosis Society, Geneva, Switzerland. 2003.

Centers for Disease Control and Prevention, Leptospirosis general information. 2005.

World health organization, zoonoses and veterinary public health leptospirosis, world health organization. 2006.

Hartskeer RA, Collares-Pereira M, Ellis WA. Emergence, control and re-emerging leptospirosis: dynamics of infection in the changing world. Clin Microbiol Infect. 2011;17:494.

Green-Mckenzie, Leptospirosis in humans. 2005.

Muthusethupathy MA, Sivakumar S, Suguna R, Jayakumar M, Vijayakumar R, Everard COR. Leptospirosis in Madras a clinical and serological study. J assoc phy India. 1995;(7):456-8.

Leptospirosis, Laboratory Manual, Regional Medical Research Centre, ICMR and WHO. 2007.

Joyce D, Coghlan. Leptospira, Borrelia, Mackie and McCarteney Practical Medical Microbiology, Thirteenth Edition. (Churchill Liingstone, London). 671.

Galton MM, Powers DK, Hall AD, Cornell RG. A rapid macroscopic slide screening test for the serodiagnosis of leptospirosis. Am J Vet Res. 1958;19:505-12.

Davol PA. Canine leptospirosis: current issues on infection and vaccination. 2006.

Sumathi G, Narayanan R, Shivakumar S. Leptospirosis laboratory, Madras medical college: Review of our experience (2004-2006) Indian Journal of Medical Microbiology. 2008;26:206-7.




How to Cite

Kanimozhi, R., Geetha, R., Anitha, D., & Ramesh, V. . (2016). A serological study of leptospirosis in Chennai. International Journal of Research in Medical Sciences, 4(1), 268–271. https://doi.org/10.18203/2320-6012.ijrms20160041



Original Research Articles