Published: 2018-04-25

Study of anaemia in type 2 diabetes mellitus

Deepali Kaushik, Raman Parashar, Praveen K. Malik


Background: Anaemia is increasingly recognized entity in the patients with diabetes mellitus and constitutes an additional burden in patients. The prevalence of anaemia in the patients with diabetes is two or three times higher than in patients with comparable renal impairment and iron stores in the general population. As India is foreseen a diabetic capital of the world, it becomes imperative to recognize co-morbidities such as anaemia at the earliest. Hence this study is being conducted with the aim to determine the prevalence and various causes of anaemia in diabetics.

Methods: After obtaining informed written consent, all diabetics patients were subjected to detailed history, through clinical examination and investigation with CBC, Renal function test including creatinine clearance. The difference of mean between anaemic and non anaemic diabetic patients was evaluated by unpaired student t test. Finally, correlation between the level of haemoglobin and index of renal damage (albumin-creatinine ratio) was accessed by Pearson correlation. Statistical software of SPSS 10 ver. and EXCEL (office 9) was used to analyse the data.

Results: In the present study, nearly two third patients of type 2 diabetes mellitus were anaemic. The maximum number of anaemic patients with type 2 diabetes mellitus had microcytic hypochromic type of anaemia.

Conclusions: It is therefore concluded that anaemia is a prevalent finding in patients with type 2 diabetes mellitus and represents significant unrecognised burden. The anaemia may be attributed to variable contribution of iron deficiency state and chronic inflammation as result of the disease itself.


Anaemia, Albuminuria, CKD, Diabetes

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SR Iyer. Type 2 diabetes, ‘express highway’ where is the “U”turn? JAPI. 2003;15:494-500.

Powers AC, Kasper DL, Braunwald E, Fauci A S, Hauser SL, Longo DL, Jamson JL, et al. Harrison’s Principles of Internal Medicine.16th Ed. New York Mc Graw Hill;2005:2152-80.

Zimmet P, Shaw J, Murray S, Sicree R. The diabetes epidemic in full flight: forecasting the future. Diabetes voice. 2003;4:1-16.

Thomas MC, Maclasaac RJ, Tasalamandris C, Molyneaux L, Goubina I, Yue D, et al. Anaemia in patients with type I diabetes. J Clin endocrionl Metab. 2004;89(9):4359-63.

Thomas MC, Maclsaac RJ, Tsalamandris C, Molyneaux L Goubina I, Fulcher G, et al. The burden of anaemia in type 2 diabetes and the role of nephoropathy: a cross sectional audit. Nephrol dial transplant. 2004;19(7):1792-97.

Astor BC, Muntner P, Levin A, Eustace JA, Coresh J. Association of kidney function with anemia: The Third National Health and Nutrition Examination Survey (1988-1994). Archives internal medicine. 2002;162(12):1401-8.

National anaemia action council. Anaemia: A Hidden Epidemic. Los angles, CA: Health vision communications, Inc. 2002.

Ezenwaka C E, Jones Le Cointe A, Nwagbara E, Seales D, Okali F. Anaemia and Kidney dysfunction in Caribbean type 2 diabetic patients. Cardiovasc diabetol. 2008;7:25.

Cawood TJ, Buckley U, Murray A Corbett M, Dhillon D, Goodwin B, et al. Prevalence of anaemia in patients with diabetes mellitus. Irish J Med Sci. 2006;175(2):25-7.

Yun Y S, Lee H C, Yoo N C, Song Y D, Lim S K, Kim K R, Hahn J S, et al. Reduced erythropoietin responsiveness to anaemia in diabetic patients before advanced diabetic nephropathy. Diabetic Res Clin Prac. 1999;46:223-9.