Spectrum of uropathogens and their antibiotic sensitivity pattern in diabetes mellitus patients at a tertiary care hospital in Odisha, India

Authors

  • Malati Murmu Department of General Medicine, VSS.I.M.S.A.R, Burla, Sambalpur, Odisha, India
  • Karun Mahesh K. P. Department of General Medicine, VSS.I.M.S.A.R, Burla, Sambalpur, Odisha, India
  • Rajesh Kumar Meher Department of General Medicine, VSS.I.M.S.A.R, Burla, Sambalpur, Odisha, India
  • Butungeshwar Pradhan Department of General Medicine, VSS.I.M.S.A.R, Burla, Sambalpur, Odisha, India
  • Ayaskanta Kar Department of General Medicine, VSS.I.M.S.A.R, Burla, Sambalpur, Odisha, India
  • Manoranjan Naik Department of General Medicine, VSS.I.M.S.A.R, Burla, Sambalpur, Odisha, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20181432

Keywords:

Antibiotic sensitivity, Diabetes Mellitus, Urinary tract infection, Uropathogen

Abstract

Background: Diabetes Mellitus is the most common endocrine disorder involving almost all systems of body. Untreated or poorly treated Diabetics are susceptible to develop a series of complications responsible for raised morbidity and mortality. Diabetes Mellitus has a number of long term effects on the Genitourinary system. Urinary tract infections have long been recognised as a significant problem in patients with Diabetes Mellitus.

Methods: Prospective observational study. Diabetic patients with culture positive UTI were included. Gestational diabetes, Immunocompromised patients and patients with congenital renal anatomical abnormalities were excluded.

Results: Authors included 211 numbers of culture positive UTI among diabetic patients. Out of which, 65 were male and 146 were female. Maximum number of patients belong to 56-65 years age group. Escherichia coli was the predominant organism isolated. Gram positive organisms showed 100% sensitivity to Vancomycin and Linezolid. Gram negative organisms showed 100% sensitivity to Polymyxin B.

Conclusions: Genitourinary tract infection is not an infrequent complication seen in diabetes patients. Most common causative organism and their antibiotic sensitivity pattern should be done in tertiary care hospital for a better antibiotic policy.

References

Bagdade JD, Root RK, Bulger RJ. Impaired leukocyte function in patients with poorly controlled diabetes. Diabetes. 1974 Jan 1;23(1):9-15.

Vergani D, Johnston C, B-Abdullah N, Barnett AH. Low serum C4 concentrations: an inherited predisposition to insulin dependent diabetes?. Br Med J (Clin Res Ed). 1983 Mar 19;286(6369):926-8.

Geerlings SE, Hoepelman AI. Immune dysfunction in patients with diabetes mellitus (DM). Pathogens and Disease. 1999 Dec 1;26(3‐4):259-65.

Peleg AY, Weerarathna T, McCarthy JS, Davis TM. Common infections in diabetes: pathogenesis, management and relationship to glycaemic control. Diabetes/metabolism research and reviews. 2007 Jan 1;23(1):3-13.

Geerlings SE, Brouwer EC, Van Kessel KC, Gaastra W, Stolk RP, Hoepelman AI. Cytokine secretion is impaired in women with diabetes mellitus. European journal of clinical investigation. 2000 Nov 25;30(11):995-1001.

Price CL, Al Hassi HO, English NR, Blakemore AI, Stagg AJ, Knight SC. Methylglyoxal modulates immune responses: relevance to diabetes. Journal of cellular and molecular medicine. 2010 Jun 1;14(6b):1806-15.

Joshi N, Caputo GM, Weitekamp MR, Karchmer AW. Infections in patients with diabetes mellitus. New England Journal of Medicine. 1999 Dec 16;341(25):1906-12.

Vardakas KZ, Siempos II, Falagas ME. Diabetes mellitus as a risk factor for nosocomial pneumonia and associated mortality. Diabetic Medicine. 2007 Oct 1;24(10):1168-71.

Flyvbjerg A. Diabetic angiopathy, the complement system and the tumor necrosis factor superfamily. Nature reviews endocrinology. 2010 Feb;6(2):94.

Mowat AG, Baum J. Chemotaxis of polymorphonuclear leukocytes from patients with diabetes mellitus. New England journal of medicine. 1971 Mar 25;284(12):621-7.

Schaeffer AJ, Jones JM, Dunn JK. Association of in vitro Escherichia coli adherence to vaginal and buccal epithelial cells with susceptibility of women to recurrent urinary-tract infections. New England Journal of Medicine. 1981 Apr 30;304(18):1062-6.

Janifer J, Geethalakshmi S, Satyavani K, Viswanathan V. Prevalence of lower urinary tract infection in South Indian type 2 diabetic subjects. Indian Journal of nephrology. 2009 Jul;19(3):107.

Kayima JK, Otieno LS, Twahir A, Njenga E. Asymptomatic bacteriuria among diabetics attending Kenyatta National Hospital. East African medical journal. 1996 Aug;73(8):524-6.

Aswani SM, Chandrashekar UK, Shivashankara KN, Pruthvi BC. Clinical profile of urinary tract infections in diabetics and non-diabetics. The Australasian medical journal. 2014;7(1):29.

Shill MC, Huda NH, Moain FB, Karmakar UK. Prevalence of uropathogens in diabetic patients and their corresponding resistance pattern: results of a survey conducted at diagnostic centers in Dhaka, Bangladesh. Oman medical journal. 2010 Oct;25(4):282.

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Published

2018-04-25

How to Cite

Murmu, M., K. P., K. M., Meher, R. K., Pradhan, B., Kar, A., & Naik, M. (2018). Spectrum of uropathogens and their antibiotic sensitivity pattern in diabetes mellitus patients at a tertiary care hospital in Odisha, India. International Journal of Research in Medical Sciences, 6(5), 1549–1553. https://doi.org/10.18203/2320-6012.ijrms20181432

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Original Research Articles