Kimura’s disease: a diagnostic and therapeutic enigma

Vinay Bharat, Abhishek Gupta, Rani Bansal, Priya Gupta, Mamta Gupta


Kimura’s disease is a rare chronic inflammatory disorder present in 2nd and 3rd decade. It has a predilection for head and neck region presenting as a slowly growing painless swelling. It is usually accompanied by peripheral eosinophilia and elevated serum IgE and hence it was initially thought to be of allergic origin. Histologically the lesions are characterized by reactive hyperplasia of lymph nodes, eosinophilic infiltration and increase in postcapillary venules. Authors have reported a male patient with a slowly growing right sided neck swelling which is recurring even after course of steroids and excision done twice at an interval of 6 months. Kimura’s disease although a benign Lymphoid disorder but the incidence of recurrence despite taking treatment is a cause of much concern for the patient.


Clinical dilemma, Histopathology, Kimura’s disease, Lymphadenopathy

Full Text:



Faras F, Abo-Alhassan F, Al-Sebeih K, Bastaki J. Kimura disease manifesting as synchronous bilateral parotid swelling in a young middle-eastern patient. Case reports in surgery. 2014;2014.

Shin GW, Lee SJ, Jung CH, Park YM, Jeong HW, Lee SM, et al. Imaging Findings of Kimura’s Disease in the soft tissue of the upper extremity AJR. 2005;184:193-9.

Guimaraes CS, Moulton-Levy N, Sapadin A, Vidal C. Kimura's Disease Case Reports in Medicine, vol. 2009, Article ID 424053, 4 pages, 2009.

Maleki D, Sayyah A, Rahimi-Rad MH, Gholami N. Kimura’s Disease with eosinophilic panniculitis - treated with cyclosporine: Allergy, Asthma and Clinical Immunology. 2016:5.

Kumar V, Salini SH. Kimura’s disease: An uncommon cause of lymphadenopathy. Ind J of Med & Paedia Oncolo. 2010 Jul;31(3):89.

Jani A, Coulson M. Kimura’s disease: a typical case of a rare disorder, West J Med. 1997;166:142-4.

Prasad BK, Deviprasad R. Kimura’s disease: an unusual case of neck mass. Indian Journal of Otolaryngology and Head and Neck Surgery. 2008;60(4):353-5.

Biradar A, Patil AV, Kotennavar MS, Venkatachalaiah M. Kimura’s disease, a case report Ind J of Surge. 2013;75(1):430-1.

Irish JC, Kain K, Keystone JS, Gullane PJ, Dardick I. Kimura’s disease: an usual cause of head and neck masses. J of Otolaryngo.1994;l.23(2)88-91.

Day TA, Abreo F, Hoajsoe DK, Aarstad RF, Stucker FJ. Treatment of Kimura’s disease: a therapeutic enigma, Otolaryngology-Head and neck Surgery. 1995;112(2):333-7.

Li TJ, Chen XM, Wang SZ, Fan MW, Semba I, Kitano M. Kimura's disease: a clinicopathologic study of 54 Chinese patients. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 1996 Nov 1;82(5):549-55.

Ioachim HL, Medeiros LJ. Ioachim’s Lymph Node Pathology. 4th edition. Wolters Kluwer/Lippincott William and Wilkins; 2009.