DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20181485

Comparative evaluation of satranidazole and ornidazole effectiveness in the treatment of chronic periodontal diseases along with mechanical debridement

Bharat Bhushan Awasthi, Saurabh Singh

Abstract


Background: Periodontitis is a common chronic inflammatory dental disease, which occurs due to the existence of pathogenic microorganisms within the gingival plaque and lead to the formation of periodontal pocket. This study was aimed to evaluate the effectiveness of satranidazole and ornidazole in the treatment of chronic periodontal diseases along with mechanical debridement.

Methods: Forty subjects were randomly selected to access the effectiveness of selected drugs on the basis of clinical and microbiological investigations over a period of 14 days. Six Ramfjord teeth (i.e. 16, 21, 24, 36, 41 and 44) were examined for investigating clinical parameters such as gingival inflammation, pocket depth and bleeding on probing. Microbiological investigations were carried out to examine the presence of gram positive (cocci and bacilli), gram negative (cocci and bacilli) and spirochaetes.

Results: A substantial progress was recorded in treating gingival inflammation, pocket depth and bleeding on probing. The results of microbiological investigations suggest that the satranidazole and ornidazole were equally effective when used alone and with scaling and root planning in reducing microbial infections. The results indicated a significant (p <0.0001) effect of model drugs on clinical and microbiological parameters in different study subjects at baseline (pre-treatment), and 7 days and 14 days post treatment.

Conclusions: The results concluded that ornidazole is better than satranidazole in treating periodontal diseases.


Keywords


Bleeding on probing, Gingival inflammation, Periodontitis, Pocket depth

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References


Dentino A, Lee S, Mailhot J, Hefti AF. Principles of periodontology. Periodontol 2000. 2013;61(1):16-53.

Browning JR. The flossophy of oral hygiene: the relationship between periodontal disease and cardiovascular disease. 2017.

Chapple IL, Genco R. Diabetes and periodontal diseases: consensus report of the joint EFP/AAP workshop on periodontitis and systemic diseases. J Clin Periodontol. 2013;40(s14).

Loesche WJ, Syed SA, Morrison EC, Laughon B, Grossman NS. Treatment of periodontal infections due to anaerobic bacteria with short-term treatment with metronidazole. J Clin Periodontol. 1981;8(1):29-44.

Kamma JJ, Nakou M, Manti FA. Predominant microflora of severe, moderate and minimal periodontal lesions in young adults with rapidly progressive periodontitis. J Periodontal Res. 1995;30(1):66-72.

Kamma JJ, Nakou M, Baehni PC. Clinical and microbiological characteristics of smokers with early onset periodontitis. J Periodontal Res. 1999;34(1):25-33.

Moore WE, Moore LV. The bacteria of periodontal diseases. Periodontol 2000. 1994;5:66-77.

Yap A. Oral health equals total health: A brief review. J Dentistry Indonesia. 2017;24(2):59-62.

Joshi D, Garg T, Goyal AK, Rath G. Advanced drug delivery approaches against periodontitis. Drug Del. 2016;23(2):363-77.

Mundade Y, Srivastava A, Somani R, Kulkarni K. A comparative study for efficacy and tolerability of satranidazole plus ofloxacin versus ornidazole plus ofloxacin in periodontal infections. 2013.

Elter JR, Lawrence HP, Offenbacher S, Beck JD. Meta-analysis of the effect of systemic metronidazole as an adjunct to scaling and root planing for adult periodontitis. J Periodontal Res. 1997;32(6):487-96.

Priyanka N, Kalra N, Saquib S, Kudyar N, Malgaonkar N, Jain H, et al. Clinical and microbiological efficacy of 3% satranidazole gel as a local drug delivery system in the treatment of chronic periodontitis: A randomized, controlled clinical trial. Contemporary Cinical Dentistry. 2015;6(3):364.

Muzaffar J, Madan K, Sharma MP, Kar P. Randomized, single-blind, placebo-controlled multicenter trial to compare the efficacy and safety of metronidazole and satranidazole in patients with amebic liver abscess. Digestive diseases sciences. 2006;51(12):2270-3.

Ralph ED. Clinical pharmacokinetics of metronidazole. Clin Pharmacokin. 1983;8(1):43-62.

Thulkar J, Kriplani A, Agarwal N. A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis. Indian J Pharmacology. 2012;44(2):243.

Pargal A, Rao C, Bhopale KK, Pradhan KS, Masani KB, Kaul CL. Comparative pharmacokinetics and amoebicidal activity of metronidazole and satranidazole in the golden hamster, Mesocricetus auratus. J Antimicrob Chemother. 1993;32(3):483-9.

Bansal K, Rawat MK, Jain A, Rajput A, Chaturvedi TP, Singh S. Development of satranidazole mucoadhesive gel for the treatment of periodontitis. AAPS Pharm Sci Tech. 2009;10(3):716.

Awasthi BB, Singh S. Evaluation of ornidazole as an adjunct to mechanical debridement and comparison of its effectiveness with metronidazole. J Chronotherapy and Drug Delivery. 2015;6(3):49-63.

Wust J. Susceptibility of anaerobic bacteria to metronidazole, ornidazole, and tinidazole and routine susceptibility testing by standardized methods. Antimicrob Agents Chemother. 1977;11(4):631-7.

Mitruka BM. Methods of detection and identification of bacteria (1977). CRC Press; 2017.

Sirockin G, Cullimore S. Practical microbiology. Mcgraw-Hill; London;1969.

Checchi L, Montevecchi M, Checchi V, Zappulla F. The relationship between bleeding on probing and subgingival deposits. An endoscopical evaluation. Open Dentistry J. 2009;3:154.

Greenstein G. The role of bleeding upon probing in the diagnosis of periodontal disease: A literature review. J Periodontol. 1984;55(12):684-8.

Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, Nardin ED. Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol. 2001;72(9):1221-7.

Oliveira SC, Slot DE, Celeste RK, Abegg C, Keijser BJ, Van der Weijden FA. Correlations between two different methods to score bleeding and the relationship with plaque in systemically healthy young adults. J Clin Periodontol. 2015;42(10):908-13.

Mousques T, Listgarten MA, Stoller NH. Effect of sampling on the composition of the human subgingival microbial flora. J Periodontal Res. 1980;15(2):137-43.

Loesche WJ, Syed SA, Morrison EC, Laughon B, Grossman NS. Treatment of periodontal infections due to anaerobic bacteria with short-term treatment with metronidazole. J Clin Periodontol. 1981;8(1):29-44.

van Winkelhoff AJ1, van der Velden U, de Graaff J. Microbial succession in recolonizing deep periodontal pockets after a single course of supra- and subgingival debridement. J Clin Periodontol. 1988;15(2):116-22.

Badersten A, Nilveus R, Egelberg J. Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis. J Clin Periodontol 1984;11(1):63-76.

Sato K, Yoneyama T, Okamoto H, Dahlen G, Lindhe J. The effect of subgingival debridement on periodontal disease parameters and the subgingival microbiota. J Clin Periodontol. 1993;20(5):359-65.