DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20182825

Study of biochemical parameters of atherosclerosis male patients in tertiary care hospital of Rewa, Madhya Pradesh, India

Drutpal Singh Baghel, Adesh Patidar

Abstract


Background: Atherosclerosis is characterized by intimal lesions called atheromas or atheromatous or fibro fatty plaques which protrude into and obstruct vascular lumens and weaken the underlying media. Global in distribution, atherosclerosis over whelming contributes to more mortality approximately half of all deaths and serious morbidity in the Western World than any other disorder. The atherosclerotic plaque is a lumpy thickening of the arterial wall, narrows the passage way and initiates the formation of a blood clot that can ultimately close down a critical artery. The objective of the study was to comparative biochemical parameters in different age group of atherosclerosis male patients.

Methods: It was a prospective study, conducted in department of medicine of tertiary care hospital at Rewa. 30 atherosclerotic patients were selected for this study on the basis of inclusion and exclusion criteria, Biochemical testing was done for all patients and data of biochemical parameters were reported as the Mean±SD. Results were performed by the unpaired student’s t-test.

Results: Total 30 atherosclerosis male patients and 27 normal healthy male volunteers were enrolled for the study. Biochemical parameters of both of this group were compared with t-test and p-value was found significant.

Conclusions: Risk factors such as elevations in body mass index, systolic blood pressure, serum LDL cholesterol, triglyceride concentration and cigarette smoking are significantly related to the extent of atherosclerotic lesions.


Keywords


Atherosclerosis, Biochemical parameter, Body mass index, Smoking

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References


Cotran RS, Kumar V, Collins T. Robbins Pathologic Basis of Diseases. 7th ed. Philadelphia: W B Saunders;2005.

Golshahi J, Rojabi P, Golshahi F. Frequency of atherosclerotic lesions in coronary arteries of autopsy specimens in Isfahan forensic medicine center. J Res med. 2005;1(10):16-19.

Enas EA, Yusuf S, Mehta JL. Prevalence of coronary artery disease in Asian Indians. Am J Cardiol. 1992;70:945-9.

Chattopadhayay A, Agnihotram VR. Burden of disease in Rural India: an analysis through cause of death. Int J 3rd World Med. 2005;2.

Gupta R. Recent trends in coronary heart disease epidemiology in India. Indian Heart J. 2008;60:B4-B18.

Sharrett AR, Patsch W, Sorlie PD, Heiss G, Bond MG, Davis CE. Associations of lipoprotein cholesterols, apolipoproteins AI and B, and triglycerides with carotid atherosclerosis and coronary heart disease. The Atherosclerosis Risk in Communities (ARIC) Study. Arteriosclerosis, Thrombosis, and Vascular Biology. 1994 Jul 1;14(7):1098-104.

Dong Zhao Ming, Brown Allison A, Wagner Denisa D, et. al. Prominent role of p-selectin in the development of advanced atherosclerosis in ApoE-deficient mice. Circulation. 2000;101:2290-2295.

Mahajan V, Handa R, Kumar U, Sharma S, Gulati G, Pandey RM, Lakshmy R. Assessment of atherosclerosis by carotid intimomedial thickness in patients with rheumatoid arthritis. JAPI. 2008 Aug 5;56:587-90.

Joshi SR. Indian diabetes risk score. J Assoc Physicians India. 2005;53:755-57.

Joshi SR. Sub clinical diabetes-vascular threat to Asian Indians. J Assoc Physicians India. 2003;51:756-7.

Mathur KS, Kashyap SK, Kumar V. Correlation of the extent and severity of atherosclerosis in the coronary and cerebral arteries. Circulation. 1963 May 1;27(5):929-34.

Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature. 1993;362:801-9.

Murray CJL, Lopez AD. Mortality by cause for eight regions of the world: global Burden of Disease Study. Lancet. 1997;349:1269-76.

Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med. 1992;326:242-50.

Padmavati S, Sandhu I. Incidence of coronary artery disease in Delhi from medico-legal autopsies. Ind J Med Res. 1969;57:465-75.

Tandon OP, Aggarwal VC, Katiyar BC. Coronary a atherosclerosis. Indian Heart J. 1969;5:10.

Bhargava MK, Bhargava SK. Coronary atherosclerosis in North Karnataka. Ind J Pathol Microbiol. 1975;18:65-77.

La Rosa J C. Prevention and treatment of coronary heart disease who benefits? Circulation. 2001;104:1688-92.

Smith SC, Jackson R, Pearson TA, Fuster V, Yusuf S, Faergeman O, et al. Principles for national and regional guidelines on cardiovascular disease prevention: a scientific statement from the World Heart and Stroke Forum. Circulation. 2004 Jun 29;109(25):3112-21.

Pearson TA. Coronary arteriography in the study of the epidemiology of coronary artery disease. Epidemiol Rev. 1984;6:140-66.

Hennerici M, Aulich A, Sandmann W, Freund HJ. Incidence of asymptomatic extracranial arterial disease. Stroke. 1981;12:750-8.

Roederer GO, Langlois YE, Jager KA, Primozich JF, Beach KW, Phillips DJ, et al. The natural history of carotid arterial disease in asymptomatic patients with cervical bruits. Stroke. 1984;15:605-13.

Autret A, Pourcelot L, Saudeau D, Marchal C, Bertrand P, de Boisvilliers S. Stroke risk in patients with carotid stenosis. Lancet. 1987;1:888-90.

Berenson GS, Srinivasan SR, Bao W, Newman WP, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. New Eng J Med. 1998 Jun 4;338(23):1650-6.

Pitsiou GG, Argyropoulou-Pataka P. Woman and smoking. Pneumon. 2007;20(1):35-40.

Singh H, Oberoi SS, Gorea RK, Bal MS. Athersclerosis in coronaries in Malwa Region of Punjab. JIAFM. 2005;27(4):236-9.

Keche AS, Tirpude BH, Bobade HJ. Correlation of Risk Factors with Coronary Atherosclerosis. J Indian Acad Forensic Med. 2012;34(2)114-6.

Chung NN, Yang CF, Kam PL, Ting WK. High density lipoprotein cholesterol level in Chinese. Chin Med J. 1981;28:59-64.

Woo J, Ho SC, Donnan SPB, Swaminathan R. Nutritional correlates of blood pressure in elderly Chinese. J Hum Hypertens. 1988;1:287-91.

Holme I, Enger SC, Helgeland A, Hjermann I, Leren P, Lund-Larsen PG, et al. Risk factors and raised atherosclerotic lesions in coronary and cerebral arteries: Statistical analysis from the Oslo study. Arteriosclerosis. 1981;1:250-256.

Kuller L, Reisler DM. An explanation for variations in distribution of stroke and arteriosclerotic heart disease among populations and racial groups. Am J Epidemiol. 1971;93:1-9.