DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20183252

Spectrum of bone and soft tissue tumors in a tertiary cancer institute in Eastern india

Ashwini Natekar, Shubasis Basu, Gavruv Gupta, Maruti Pujari

Abstract


Background: Bone and soft tissue tumours are uncommon tumours that can affect any age group. Soft tissue tumors are said to be heterogeneous group of mesenchymal malignancies. Primary bone sarcomas are rare tumors, comprising approximately 0.2% of all cancers. Their true incidence is difficult to estimate because of their rarity. The outcome of the disease depends on the age and time at diagnosis.

Methods: A study was carried out in department of pathology in tertiary cancer institute in East India from December 2015 to September 2017. A total of 60 cases were included in the study. All age group patients with indoor admissions and review cases were included in this study. Only soft tissue and bone tumors were included in the study. Epithelial tumors metastasis to bone were excluded from our study. Clinical and radiological details of patients were noted along with gross specimen findings and microscopic examination of H and E stained slides. IHC was also carried out for confirmatory diagnosis. Aims and objectives was to study the histological spectrum of bone and soft tissue tumors in a tertiary cancer institute in Eastern India. Also, to study gender distribution and site distribution of bone and soft tissue tumors.

Results: Out of the total 60 cases studied 24 cases were of bone and cartilaginous tumours and 36 cases included were of soft tissue tumors. Benign tumors comprised of 08 cases (13.3%) and malignant tumors accounted to 52 cases (86.7%). Age of the patients ranged from 10 to 80 years. Male female ratio was 1.4:1.

Conclusions: Multimodal therapies of treatment are practiced for bone and soft tissue tumors. Early detection and treatment is essential for diagnosis of these malignant tumors. Molecular studies are most important in diagnosing, classifying and also prognosticating bone and soft tissue tumors.


Keywords


Bone tumors, Histology, Soft tissue tumors

Full Text:

PDF

References


Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Altekruse SF, et al. editors. SEER Cancer Statistics Review. Bethesda, MD: National Cancer Institute; 1975-2013. Last accessed on 2016 Jun 01.

Jain P, Shrivastava A, Mallik R. Clinicomorphological assessment of soft tissue tumors. Sch J App Med Sci. 2014;2(2D):886-90.

Hassawi BA, Suliman AY, Hasan IS. Soft tissue tumours-histopathological study of 93 cases. Ann Coll Med Mo Sul. 2010;36(1and2):92-8.

Weiss SW, Goldblum JR. General Considerations. In Enzinger and Weiss’s Soft Tissue Tumours, 4th edition: Mosby Publication. 2001;20011-19.

Beg S, Vasenwala SM, Haider N, Ahmad SS, Maheshwari V, Khan MA. A comparison of cytological ad histopathological findings and role of immunostains in the diagnosis of soft tissue. J Cytol. 2012;29(2):125-130.

Lazim AF, Bedoor AK, Al-Irhayim. Soft tissue sarcomas in Mosul: a pathologic evaluation. Ann Coll Med Mosul. 2008;34(2):152-160.

Zhi-wei F, Jing C, Sheng T, Yong C, Rui-feng X. Analysis of soft tissue sarcomas in 1118 cases. Chinese Med J. 2009;122(1):51-53.

Batra P, Gupta DO, Batra R, Kothari R, Bokariya P. Pattern of soft tissue tumours In: a rural population of central India. Innovative J Med Heal Sci. 2013;3(3):124-6.

Ramaswamy A, Rekhi B, Bakhshi S, Hingmire S, Agarwal M. Indian data on bone and soft tissue sarcomas: A summary of published study results. South Asian J Cancer. 2016 Jul;5(3):138.

Applebaum MA, Worch J, Matthay KK, Goldsby R, Neuhaus J, West DC, et al. Clinical features and outcomes in patients with extraskeletal Ewing sarcoma. Cancer. 2011 Jul 1;117(13):3027-32.

Askin FB, Rosai J, Sibley RK, Dehner LP, Mc Alister WH. Malignant small cell tumour of the thoracopulmonary region in childhood: a distinctive clinicopathologic entity of uncertain histogenesis. Cancer. 1979;43:2438-51.

Sabati JM, Franquet T, Parellada JA, Monill JM, Oliva E. Malignant neuroectodermal tumour of the chest wall (Askin tumour): CT and MR findings in eight patients. Clinical Radiology. 1994;49:634-8.

Winer-Muram HT, Kaufman WH, Gronemeyer SA, Gregory JS. Primitive neuroectodermal tumors of the chest wall (Askin tumors). CT and MR findings. Am J Res. 1985;145:517-20.

Dewan M, Malatani TS, Ansari MA. Lessons to be learned: A case study approach Malignant melanoma of soft tissue. J R Soc Health. 2005;125:42-6.

Crowson A, Magro C, Mihm M. Unusual histologic and clinical variants of melanoma: Implications for therapy. Curr Oncol Rep. 2007;9:403-10.

Lucas DR, Nascimento AG, Sim FH. Cell sarcoma of soft tissues: Mayo Clinic experience with 35 cases. Am J Surg Pathol. 1992;16:1197-204.

Enzinger FM. Clear cell sarcoma of tendons and aponeuroses: An analysis of 21 cases. Cancer. 1965;18:1163-76.

Mavrogenis AF, Bianchi G, Stavropoulos NA, Papagelopoulos PJ, Ruggieri P. Clinicopathological features, diagnosis and treatment of clear cell sarcoma/melanoma of soft parts. Hippokratia. 2013;17(4):298-302.

Meis Kindblom JM. Clear cell sarcoma of tendons and aponeuroses: A historical perspective and tribute to the man behind the entity. Adv Anat Pathol. 2006;13:286-92.

Hocar O, Le Cesne A, Berissi S, Terrier P, Bonvalot S, Vanel D, et al. Clear cell sarcoma (malignant melanoma) of soft parts: a clinicopathologic study of 52 cases. Dermatology research and practice. 2012;2012.