Published: 2018-07-25

Neuropathic pruritus: an early indicator of neuromyelitis optica spectrum disorders

Pradeep Kumar Bansal, C. L. Nawal, Aradhana Singh, Radheyshyam Chejara, Sebastian Marker, Pankaj Mangal


Neuromyelitis optica is a relapsing, inflammatory astrocytopathic disorder, affecting predominantly the optic nerves and spinal cord. It is associated with antiaquaporin-4 immunoglobulin G (AQP4-IgG) in up to 70% of patients. Spinal cord involvement typically presents as a longitudinally-extensive transverse myelitis, with associated sensorimotor and sphincter dysfunction. Sensory symptoms such as numbness, dysaesthesia, pain and tonic spasms are common. Here, we present a case of a 25years old female who came to the medicine OPD, with the chief complaints of intense itching over face and forehead, which was later on progressed to quadriparesis after 3 weeks. This case highlights neuropathic pruritus as an under-recognised early feature of neuromyelitis optica.


AQP4-IgG, NMOSD, Neuropathic pruritus

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