DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20182458

Clinical pattern of superficial mycosis in rural type 2 diabetes mellitus patients

Nikhil Gupta, Vaibhav Shukla, Priyanka Shukla

Abstract


Background: Diabetic foot infections are a major cause of amputations and mortality. There is heterogeneity in type of superficial fungal infections because of change in climatic conditions and lifestyles across world. There is paucity of reports on etiology of superficial fungal infections in rural type 2 diabetes mellitus patients in India, so the present study was undertaken to find out the clinical pattern of superficial fungal infections in rural type 2 diabetes mellitus patients.

Methods: Rural type 2 diabetes mellitus patients clinically diagnosed to have superficial fungal infection were enrolled and were subjected to direct microscopy in KOH stain and fungal culture.

Results: 100 type 2 diabetes mellitus patients were enrolled (58 males and 42 females). 45 were either KOH or culture positive. 73.1% were dermatophytes and rest nondermatophytes. Trichophyton rubrum was the commonest (48.8%) dermatophyte.

Conclusions: Trichophyton rubrum was the commonest dermatophyte causing superficial infection. Besides dermatophytes non-dermatophytic fungi are also emerging as important cause of superfiicial mycosis.


Keywords


Diabetes Mellitus, Dermatophytes, KOH stain, Rural

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References


Ogurtsova K, Da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH et al. IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Research and Clinical Practice. 2017;128:40-50.

Kaveeshwar SA, Cornwall J. The current state of diabetes mellitus in India. AMJ. 2014;7:45-8.

Higa M. Clincal epidemiology of fungal Infection in diabetes Nippon Rinsho. 2008;66:2239-44.

Mayser P, Freund V, Budihardja D. Toenail onychomycosis in diabetic patients: issue and management. Am J Clin Dermatol. 2009;10:211-20.

Crawford F, Inkster M, Kleiyneny J, Fahey T. Predicting foot ulcer in patients with diabetes: a systematic review and meta-analysis. QJM. 2007;100:65-86.

Mehrotra HK, Bajaj AK, Gupta SC, Mehrotra TN, Atal PR, Agarwal AK. A study of dermatophytes at Allahabad. Indian J Pathol Microbiol. 1978;21:131-9.

Havlickova B, Czaika VA, Friedrich M. Epidemiological trends in skin mycoses worldwide. Mycoses. 2008;51:2-15.

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37:S81-90.

Casqueiro J, Alves C. Infections in patients with diabetes mellitus: A review of pathogenesis. Indian J Endocrinol Metab. 2012;16:27-36.

Bouquerra R, Essais O, Sebai N, Ben Salem L, Amari H, Kammoun MR, et al. Prevalence and clinical aspects of superficial mycosis in hospitalized diabetic patients in Tunisia. Med Mal Infect. 2004;34:201-5.

Thilak S, Anbumalar M, Sneha PM. Cutaneous fungal infections in subjects with diabetes mellitus. Int J Res Dermatol. 2017;3:55-8.

Eckhard M, laxgler A, Liersch J, Bretzel RG, Mayser P. Fungal foot infector in patients with diabetes mellitus-results of two independent investigators. Mycoses. 2007;50:14-9.

Delamaire M, Maugendre D, Moreno M, LeGoff MC, Allannic H, Genetet B. Impaired leukocyte function in diabetic patients. Diabet Med. 1997;14:29-34.

Mishra M, Mishra S, Singh PC, Mishra BC. Clinicomycological profile of superficial mycoses. Indian J Dermatol Venereol Leprol. 1998;64:283-5.

Attapattu MC. The pattern of superficial mycotic infections in Sri Lanka. Ceylon Med J. 1980;25:86-95.

Grover S, Roy P. Clinico-mycological profile of Superficial Mycosis in a Hospital in North-East India. MJAFI. 2003;59:114-6.

Nair S, Peter S, Sasidharan A, Sistla S, Unni AK. Incidence of mycotic infections in diabetic foot tissue. J Cult Collect. 2006;5:85-9.

Gupta AK, Konnikov N, MacDonald P, Rich P, Rodger NW, Edmonds MW, et al. Prevalence and epidemiology of toenail onychomycosis in diabetic subjects: A multicentre survey. Br J Dermatol. 1998;139:665-71.

Romano C, Massai L, Asta F, Signorini AM. Prevalence of dermatophytic skin and nail infections in diabetic patients. Mycoses. 2001;44:83-6.