DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20183633

Clinico-physiological profile of patients of pulmonary impairment after tuberculosis at a tertiary care centre

Gajendra V. Singh, Antriksh Srivastava, Vinisha Chandra, Santosh Kumar, Rishabh Goel

Abstract


Background: Pulmonary tuberculosis (TB) is a unique infectious disease that more often results in permanent structural changes in the lung parenchyma. It is by virtue of these changes that the patients even after bacteriological cure continue to suffer the after effects of the disease. Objective of study was to assess the clinico-physiological profile of patients of pulmonary impairment after tuberculosis (PIAT) attending S. N. Medical College, Agra, Uttar Pradesh, India.

Methods: Over the time period of 2 years, 350 patients of healed pulmonary tuberculosis were identified and studied about their clinico-physiological profile. This profile included age, sex, category of treatment, pulmonary function test pattern, exercising capacity, exercise tolerance and quality of life.

Results: It was found that majority of the patients were males, >60 years of age and had taken Category-II treatment. Most of the patients were having an obstructive pattern on PFT, poor exercise tolerance and exercise capacity and a poor quality of life.

Conclusions: Patients of healed pulmonary TB continue to experience respiratory symptoms owing to the permanent anatomical changes in the lung conferred by the disease.


Keywords


Healed Pulmonary TB, PIAT, Pulmonary impairment

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References


Pasipanodya JG, McNabb SJ, Hilsenrath P, Bae S, Lykens K, Vecino E, et al. Pulmonary impairment after tuberculosis and its contribution to TB burden. BMC Public Health. 2010 Dec;10(1):259.

Dheda K, Booth H, Huggett JF, Johnson MA, Zumla A, Rook GA. Lung remodeling in pulmonary tuberculosis. J Infect Dis. 2005;192:1201-9.

Curtis JK. The significance of bronchiectasis associated with pulmonary tuberculosis. Am J Med. 1957;22:894-903.

Rosenzweig DY, Stead WW. The role of tuberculosis and other forms of bronchopulmonary necrosis in the pathogenesis of bronchiectasis. Am Rev Respir Dis. 1966;93:769-85.

Pasipanodya JG, Miller TL, Vecino M, Munguia G, Garmon R, Bae S, et al. Pulmonary impairment after tuberculosis. Chest. 2007;131:1817-24.

Pasipanodya JG, Miller TL, Vecino M, Munguia G, Bae S, Drewyer G, et al. Using the St George's Respiratory Questionnaire to ascertain health quality in persons with treated pulmonary tuberculosis. Chest. 2007;132:1591-8.

Menezes AMB, Hallal PC, Perz-Padilla R, Jardin JRB, Muino A, Lopez MV, et al. Victora CG for the latin American project for the investigation of obstructive lung disease (PLATINO) team: tuberculosis and airflow obstruction: evidence from the PLATINO study in Latin America. Eur Respir J. 2007;30:1180-5.

Andersson GBJ, Cocchiarella L, eds: Guides to the Evaluation of Permanent Impairment. 5th ed. AMA Press. Chicago:IL;2000:2-15.

Sodeman, WA, Sodeman TM. Pathologic physiology: mechanisms of disease. 7th ed. 1985,467 WB Saunders. Philadelphia: PA: American thoracic society. treatment of tuberculosis. MMWR Morb Moral Wkly Rep. 2003;52:1-77.

Long R, Maycher B, Dhar A, Manfreda J, Hershfield E, Anthonisen N. Pulmonary tuberculosis treated with directly observed therapy: serial changes in lung structure and function. Chest. 1998 Apr 1;113(4):933-43.

Gaensler, EA, Lindgren I. Chronic bronchitis as an etiologic factor in obstructive emphysema, preliminary report. Am Rev Res Dis. 1959;80:185-93.

Snider GL, Doctor L, Demas TA, Shaw AR. Obstructive airway disease in patients with treated pulmonary tuberculosis. Am Rev Res Dis. 1971;103(5):625-40.

Wilcox PA, Ferguson AD. Chronic obstructive airways disease following treated pulmonary tuberculosis. Respir Med. 1989;83:195-8.

Weiner H. Changes in employment status associated with hospitalization for tuberculosis: analysis of 163 consecutively admitted males. Am Rev Respir Dis. 1963;87:17-22.

Hnzido, E, Singh, T, Churchyard, G Chronic pulmonary function impairment by initial and recurrent pulmonary tuberculosis following treatment. Thorax. 2000;55:32-8.

Cole G, Miller D, Ebrahim T, Dreyden T, Simpson R, Manie S. Pulmonary impairment after tuberculosis in a South African population. South African J Physio. 2016;72(1):1-6.

Singh B, Chaudhary O. Trends of pulmonary impairment in persons with treated pulmonary tuberculosis. Int J Med Res Prof. 2015:8-11.

de Grass D, Manie S, Amosum SL. Effectiveness of a home-based pulmonary rehabilitation programme in pulmonary function and health related quality of life for patients with pulmonary tuberculosis: a pilot study. African health sciences. 2014;14(4):866-72.

Wilches EC, Rivera JA, Mosquera R, Loaiza L, Obando L. Pulmonary rehabilitation in multi-drug resistant tuberculosis (TB MDR): a case report. Colombia M├ędica. 2009 Dec;40(4):442-7.

Bansal V. Pulmonary rehabilitation in chronic respiratory diseases. Indian J Chest Dis Allied Sci. 2014;56:147-8.