Published: 2018-07-25

A cross sectional clinical study on correlation between myopia and intraocular pressure and ocular biometric values among adults in tertiary eye care in Palakkad, Kerala, India

Raja A. M., Rajendraprasad A., Seema G.


Background: To find out whether there is a correlation between intra ocular pressure and ocular biometric values like corneal curvature, anterior chamber depth, lens thickness and vitreous chamber depth in myopic eyes.

Methods: A cross sectional clinical study was conducted in karuna medical college hospital Palakkad Kerala, India from September 2015 to August 2017. 1000 eyes of 500 myopic patients attending the ophthalmology OPD were included in this study. Goldman applanation tonometry was used to measure intra ocular pressure. Bausch and Lomb keratometer was used to measure corneal curvature and Biometer A scan machine was used to measure anterior chamber depth, lens thickness, vitreous chamber depth and axial length.

Results: In this study majority of the patients age group was 16-20 years. The overall mean intra ocular pressure was 15mmhg and mean radius of corneal curvature was 44.12D. In this study average anterior chamber depth was 3.55mm and mean lens thickness was 3.56mm.Mean vitreous chamber depth was 18.40. In this study mean axial length was 24.60mm.

Conclusions: Amount of myopia and variation in corneal curvature was not statistically significant. There was no correlation between intra ocular pressure and degree of myopia. But anterior chamber depth, lens thickness, vitreous chamber depth and axial length were statistically very significant with amount of myopia.


Anterior chamber depth, Corneal curvature, IOP, Myopia

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David D. Michaels MD. Visual optics and refraction: a clinical approach. 2nd edition. USA, CV Mosby company, St Louis, Toranto, London. 1980:520.

Mark R. Refractive status of the eye. Borish’s clinical refraction, WB Saunders Company. 2003:2-9.

Stewart S. Duke Elder-The practice of refraction. 8th edition. 1998:79-93.

Elkington AR, Frank HJ, Greaney MJ. Clinical optics. Oxford, UK: Blackwell Science; 1999 Aug 25.

Curtin BJ. The components of refraction and their correlation in the myopias: Basic science and clinical management. Harper and Row publishers, Philadephia. 2001:17-27.

Kalikivayi V, Naduvilath TJ, Bansal AK, Dandona L. Visual impairment in school children in Southern India. Indian J Ophthalmol. 1997;45(2):129-34.

Mohan M, Pakrasi S, Zutshi R. Myopia in India. Acta Ophthalmologica. 1988 Apr;66(S185):19-23.

Sir Elder Ds, Abrams D. Dioptric imagery of the eye In: system of ophthalmology; Henry Kimpton, London. 1979;5:93-152.

Sihota R, Tandon R. Parson’s disease of the Eye. 20th edition. ophthalmic optics: Refractometry and Keratometry and Refractive Errors of the Eye. 2011:67-8.

Khurana AK. Theory and practice of optics and refraction; errors of refraction and binocular optical defects. 2nd edition. 2008:61-88.

American Academy of Ophthalmology (AAO); Basic and clinical science course. Clinical Optics. 2016-2017:72-83.

Sperduto RD, Seigel D, Roberts J, Rowland M. Prevalence of myopia in the United States. Arch Ophthalmol. 1983 Mar 1;101(3):405-7.

Becker B, Shaffer’s RN. Diagnosis and Therapy of Glaucoma. 2 Edi. 2009:73.

Abdulla MI, Hamdi M. Ocular tension in myopia and emmetropia. Br Ophthal. 1970;54:122.

Neville A, McBrien, Millodot M. A biometric investigation of late onset myopic eyes. Acta Ophthalmologica. 1987;65:461-68.

Wong Ty, Foster PJ, Ng TP, Tielsch JM, Johnson GJ, Seah SKL. Variations in ocular biometry in an adult Chinese population in Singapore: The Tanjong Pagar survey. Inv Ophthalmol Vis Sci. 2001:42(1):73-80.

Grosvenor T, Scott R. Three-year changes in refraction and its components in youth-onset and early adult-onset myopia. Optom Vis Sci. 1993:70(8):677-83.

Jiang B, Woessner WM, Vitreous chamber elongation is responsible for myopia development in young adult. Optom Vis Sci. 1996;73(4);231-34.

Pitts DA, Millodot M. Study of the depth of the anterior chamber-physiological variations with particular emphasis on ametropia a translation from the original by Messrs. Calmettes, Deodati, Huron and Bechac. Optometry Vision Science. 1966 Dec 1;43(12):765-94.

Stenstrom S. Investigation of the variation and the co-relation of the optical elements of human eyes. Am J optom Arch Am Acad Optom. 1948;25:438-51.

Lin LL, Shi HYE, Lee YC, Hung PT, Hou PK. Changes in ocular refraction and its components among medical student: a 5-year longitudinal study. Optom Vis Sci. 1996:73(7):495-98.

Erickson P. Optical components contributing to refractive components. In: Grosvenor T: Refractive anomalies Research and clinical application: Butterworth-Hienemann, Boston. 1992:199-218.

Beebe DC. The lens. In: Adler’s physiology of the eye. Mosby, Missouri. 2003:117-35.

Neville A, McBrien, Millodot M. A biometric investigation of late onset myopic eyes: Acta Ophthalmologica. 1987:65:461-68.

Wickremasingke S, Foster PJ, Uranchimeg D, Lee PS, Devereux JG, Alsbirk PH, et al. Ocular biometry and refraction in Mangolian adults. Inv Ophthalmol Vis Sci. 2004;45(8):776-83.

Fledelius HC, Miyanoto K. Diabetic myopia: is it lens induced? An occulometric study comprising ultrasound measurements. Acta Ophthalmologica. 1987:65:469-73.

Mutti DO, Zadnik K, Friedman NE. Qualley PA, Jones LA, Qiu PH. Ocular predictors of the onset of juvenile myopia. Inv Ophthalmol Vis Sci. 1999;40(9):1936-43.

Barbara E, Klein R, Moss SE. Correlates of lens thickness; the beaver dam eye study. Inv Ophthalmol Vis Sci. 1998;39(8);1507-10.

McBrien, Adams DW. A longitudinal investigation of adult onset and adult progression of myopia in an occupational group: Refractive and Biometric findings: Inv Ophthalmolo Vis Sci. 1997;38;321-33.

Goss DA, Vanveen HG, Rainey BB, Feng B. Ocular components measured by keratometry and ultrasonagraphy in Emmetropic and myopic optometry students. Optom Vis Sci. 1997;74(7):489-95.

Tanja RM, Klio BA, Inez FB, Gerd AU. Anterior chamber depth in relation to refractive status measured with orbscan topography. J Cataract Refract Surg. 2003;29:2115-21.