DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20183635

An observational study of cytopathological analysis of ascitic fluid or peritoneal washings cytology in ovarian neoplasms: correlation with histopathological parameters

Priya Jaswani, Sonal Gupta

Abstract


Background: Analysis of ascitic fluid and peritoneal washing cytology serves as a useful predictor of ovarian surface involvement and peritoneal metastasis even in the absence of clinical omental spread. The aim of the current study is to correlate peritoneal cytology with various histologic features of ovarian cancers.

Methods: It is a retrospective study.  A total of 30 cases of ovarian neoplasms were included in the study. Results of peritoneal cytology were correlated with various histologic features of ovarian tumors including histologic type, grade, tumor size, capsular invasion, and omental metastasis, using chi-square test. A p value of <0.05 was considered as statistically significant.

Results: Out of the 30 cases of ovarian tumors involved in the study, twenty-five cases were surface epithelial tumors, two sex-cord stromal tumors, one germ cell tumor, one primary ovarian lymphoma and one metastatic carcinoma. Capsular invasion was seen in 56.3 % of the cases, and omental metastasis in 46.6 % of the cases. A significant positive correlation was seen between positive peritoneal cytology and capsular invasion and omental metastasis with a p value of <0.001.

Conclusions: Peritoneal fluid cytology is an indicator of peritoneal metastasis. Positive cytology also correlates with capsular invasion and histologic type in ovarian tumors. Therefore, it should always be used as an adjunctive tool in the surgical management of ovarian tumors.


Keywords


Ascitic fluid cytology, Capsular invasion, Ovarian cancer, Omental metastasis

Full Text:

PDF

References


Stanojević Z, Rancić GŽ, Radić SS, Potić-Zečević N, Đorđević B, Marković M, et al. Pathogenesis of malignant ascites in ovarian cancer patients. Arch Oncol. 2004;12(2):115-8.

Garrison RN, Kaelin LD, Galloway RH, Heuser LS. Malignant ascites. Clinical and experimental observations. Ann Surgery. 1986 Jun;203(6):644.

Shen-Gunther J, Mannel RS. Ascites as a predictor of ovarian malignancy. Gynecol Oncol. 2002 Oct 1;87(1):77-83.

Sneige N, Thomison JB, Malpica A, Gong Y, Ensor J, Silva EG. Peritoneal washing cytologic analysis of ovarian serous tumors of low malignant potential to detect peritoneal implants and predict clinical outcome. Cancer Cytopathol. 2012 Aug 25;120(4):238-44.

Mulvany N. Cytohistologic correlation in malignant peritoneal washings. Acta Cytolog. 1996;40(6):1231-9.

Cibas ES, Ductaman BS. Diagnostic principles and clinical correlate. Saunders. 1996;129-145.

Shield P. Peritoneal washing cytology. Cytopathol. 2004;15(3):131-41.

Fadare O, Mariappan MR, Wang S, Hileeto D, Mcalpine J, Rimm DL. The histologic subtype of ovarian tumors affects the detection rate by pelvic washings. Cancer Cytopathology: Interdisciplinary Inter J Am Cancer Soc. 2004 Jun 25;102(3):150-6.

Rubin SC, Dulaney ED, Markman M, Hoskins WJ, Saigo PE, Lewis JJ. Peritoneal cytology as an indicator of disease in patients with residual ovarian carcinoma. Obstetrics Gynecol. 1988 Jun;71(6 Pt 1):851-3.

Colgan TJ, Boerner SL, Murphy J, Cole DE, Narod S, Rosen B. Peritoneal lavage cytology: an assessment of its value during prophylactic oophorectomy. Gynecol Oncol. 2002 Jun 1;85(3):397-403.

Morton DG, Moore JG. The clinical value of peritoneal lavage for cytologic examination. Obstetr Gynecol Survey. 1961 Oct 1;16(5):735-9.