Published: 2018-08-25

Evaluation of visual evoked potentials in type II diabetes mellitus subjects attending a tertiary care hospital

Gowri V.


Background: DM is the most common metabolic disorder in the world. The complications of DM take millions of lives every year. There is definite expectation to reason out both vasculopathy and neuropathy associated with DM leads to dysfunction along the visual pathway. The Visual Evoked Potentials (VEPs) as an electrophysiological method to assess conduction in type II DM subjects which is simple. This study attempted to detect earlier visual involvement before the clinical symptoms.

Methods: VEP was recorded in 100 subjects (Diabetic 50 and Controls 50) P100 latency was compared between the diabetic and age, gender matched controls.

Results: The study evidenced that the mean P 100 latency in DM subjects was found to be significantly prolonged when compared the that of controls.

Conclusions: The study will help in supervising the earlier progress of neuropathy and earlier detection of nervous system involvement to reduce the morbidity of the diabetic subject and a special care to improve their quality of life.


Neuropathy, P 100 latency, Type II diabetes mellitus, Visual evoked potentials

Full Text:



Silink M. IDF Diabetes Atlas. 4th ed. Brussels: International Diabetes Federation. 2009.

Biessels GJ, Koffeman A, Scheltens P. Diabetes and cognitive impairment. Clinical diagnosis and brain imaging in patients attending a memory clinic. J Neurol. 2006;253:477-82.

Diabetes Fact Sheet No. 312, World health organization. Available at 2008; 312/en/.

Verma A, Bisht MS, Ahuja GK. Involvement of central nervous system in diabetes mellitus. J Neurol Neurosurg Psychiatry. 1984 Apr 1;47(4):414-6.

Tavormina JG, Kastner LS, Slater PM, Watts SLJ Abnorm Child Psychol. 1976;4(2):99-110.

Shagan BP. Is diabetes a model for aging? Med Clin North Am 1976; 60(6):1209-11.

Jadzinsky M, Faerman I, Fox D.Acta Diabetol Lat 1973; X: 208-60.

Di Mario U, Morano S, Valle E, Pozzessere G. Electrophysiological alterations of the central nervous system in diabetes mellitus. Diabetes/metabolism Reviews. 1995 Oct;11(3):259-77.

Misra UK, Kalita J. In: History of Clinical Neurophysiology. Clinical Neurophysiology. 2nd ed. Elsevier, New Delhi. 2005:309-327.

Binnie C, Cooper R, Mauguiere F, Osselton J, Prior P, Tedman B. Clinical Neurophysiology. 2nd ed. Elsevier. 2004;1:353-615.

Aminoff MJ Electro diagnosis in clinical neurology. 5th edition. Health Sciences. 2012:490-492.

Sivakumar R, Ravindran G, Muthayya M, Lakshminarayannan S, Velmurughendran CU. Diabetic retinopathy analysis. J Biomed Biotechnol. 2005;2005:20-27.

Heravian J, Daneshvar R, Dashti F, Azimi A, Moghaddam HO, Yekta AA, et al. Simultaneous pattern visual evoked potential and pattern electroretinogram in strabismic and anisometropic amblyopia. Iranian Red Crescent Med J. 2011 Jan;13(1):21.

Moreo G, Mariani E, Pizzamigilio G, Colucci GB, Visual evoked potential in NIDDM: longitudinal study. Diabetologia. 1995;38(5):573-76.

Brannagan III TH, Weimer LH, Latov N. Acquired neuropathies. Merritt’s neurology. 11th ed. New York: Lippincot Williams & Wilkins. 2005:748-67.

Algan M, Ziegler O, Gehin P, Got I, Raspillar A, Weber M, et al. Visual evoked potentials in diabetic patients. Diabetic Care. 1989;12:227-9.

Mariani E, Moreo G, Colucci GB. Study of visual evoked potentials in diabetes without retinopathy: correlation with clinical findings and polyneuropathy. Acta Neurol Scand. 1990;81:337-40.

Pontr F, Giuffre G, Anastasi M, Lauricella M. Involvement of the visual evoked potentials in type I insulin dependent diabetes. Metab Pediatr Syst Ophthalmol. 1986;9:77-80.

Lieth E, Gardener TW, Barber AJ, Antonetti DA; Penn State Retina Research Group. retinal Neurodegeneration: early pathology in diabetes. Clin Experiment Ophthalmol.2000;28:3-8.

Odom JV, Bach M, Brigell M, Holder GE, McCulloch DL Tormee AP, et al. ISCEV standard for clinical visual evoked potentials (2009 update). Doc Ophthalmol. 2010;120:11-9.

Imam M, Shehata OH. Subclinical central neuropathy in Type-2 diabetes mellitus. Bull Alex Fac Med. 2009;45(1):65-73.