DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20184034

Staphylococcus associated acute throat infection among children presented to a tertiary care hospital

Santhosh John Thattil, Sumitha Santhosh, Thekkuttuparambil Ananthanarayanan Ajith

Abstract


Background: Staphylococcus infection remains one of the most common bacterial infections that cause high rate of morbidity and mortality in children and adults. This study was aimed to find the prevalent age group and type of Staphylococcus strain among the children presented with sore throat to a tertiary care hospital.

Methods: A retrospective study was done by analyzing the medical records of children (less than 10 years of age) who presented to the outpatient Paediatric department with sore throat and confirmed diagnosis of Staphylococcus. Number of coagulase negative Staphylococcus (CoNS), Staphylococcus aureus (SA), methicilline resistant (MR) and methicilline sensitive (MS) strains was analyzed in various age groups and analyzed statistically.

Results: Total 129 cases of Staphylococcus infected cases were found during the period of this study. The male to female ratio was 1.86 with high rate of prevalence found among the children of age 1-3 years (39.5%) (p= 0.0031). The CoNS was found in 65/129 (50.38%) cases and all were MSSA. No MRSA infection was found during the study period. Among the total cases, 122/129 (94.57%) cases were infected with MS strains. The MR strain was found in 7/129 cases (5.4%) which was mainly in neonates. The rate of infection was less in older children (7-10-year age).

Conclusions: The prevalence of Staphylococcus associated throat infection was high among the children of 1-3-year age with male dominance. The MR strain was found only 5.4% of cases and no MRSA found in this study.


Keywords


β-lactam antibiotics, Coagulase negative staphylococcus, Methicillin resistant Staphylococcus aureus, Panton-valentine leukocidin, Staphylococcus aureus

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References


Thwaites GE, Edgeworth JD, Gkrania-Klotsas E, Kirby A, Tilley R, Török ME, et al. UK Clinical Infection Research Group. Clinical management of Staphylococcus aureus bacteraemia. Lancet Infect Dis. 2011;11:208-22.

Davis SL, Perri MB, Donabedian SM, Manierski C, Singh A, Vager D, et al. Epidemiology and outcomes of community-associated methicillin-resistant Staphylococcus aureus infection. J Clin Microbiol. 2007;45:1705-11.

Berkovitch M, Bulkowstein M, Zhovtis D, Greenberg R, Nitzan Y, Barzilay B, et al. Colonization rate of bacteria in the throat of healthy infants. Int J Pediatr Otorhinolaryngol. 2002;63:19-24.

Hayakawa T, Hayashidera T, Yoneda K., Kagawa S., Kusunoki T. Preferential pharyngeal colonization of methicillin resistant Staphylococcus aureus in infants. J. Pediatr. 1999;134:252.

Nilsson P, Ripa T. Staphylococcus aureus throat colonization is more frequent than colonization in the anterior nares. J Clin Microbiol. 2006;44:3334-9.

Wong H, Louie L, Lo RY, Simor AE. Characterization of Staphylococcus aureus isolates with a partial or complete absence of staphylococcal cassette chromosome elements. J Clin Microbiol. 2010;48:3525-31.

Hidron AI, Kourbatova EV, Halvosa JS, Terrell BJ, McDougal LK, Tenover FC, et al. Risk factors for colonization with methicillin-resistant staphylococcus aureus (MRSA) in patients admitted to an urban hospital: emergence of community-associated MRSA nasal carriage. Clin Infect Dis. 2005;41:159-66.

Brown DF, Yates VS. Methicillin susceptibility testing of Staphylococcus aureus on media containing five percent sodium chloride. Eur J Clin Microbiol. 1986;5:726-8.

Indian Network for Surveillance of Antimicrobial Resistance (INSAR) group. Methicillin resistant Staphylococcus aureus (MRSA) in India: Prevalence and susceptibility pattern. Indian J Med Res. 2013;137:363-9.

Gopalakrishnan R, Sureshkumar D. Changing trends in antimicrobial susceptibility and hospital acquired infections over an 8 year period in a tertiary care hospital in relation to introduction of an infection control programme. J Assoc Physicians India. 2010;58:25-31.

Steven YC, Davis TJS, Eichenberger E, Holland TL, Fowler, VG Jr. Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management. Clin Microbiol Rev. 2015;28:603-61.

Robinson S, Fall C. Infant nutrition and later health: a review of current evidence. Nutrients. 2012;4:859-74.

Hamosh M. Bioactive factors in human milk. Pediatr Clin North Am. 2001;48:69-86.

Duijts L, Ramadhani MK, Moll HA. Breast feeding protects against infectious diseases during infancy in industrialized countries. A systematic review. Matern Child Nutr. 2009;5:199-210.

Allard C, Carignan A, Bergevin M, Boulais I, Tremblay V, Robichaud P, et al. Secular changes in incidence and mortality associated with Staphylococcus aureus bacteraemia in Quebec, Canada, 1991-2005. Clin Microbiol Infect. 2008:14:421-8.

Bouchiat C, El-Zeenni N, Chakrakodi B., Nagaraj S, Arakere G, Etienne J. Epidemiology of Staphylococcus aureus in Bangalore, India: emergence of the ST217 clone and high rate of resistance to erythromycin and ciprofloxacin in the community. New Microbes New Infect. 2015;7:15-20.

Klevens RM, Morrison MA, Nadle J, Petit S, Gershman K, Ray S, et al. Active Bacterial Core surveillance (ABCs) MRSA Investigators 2007. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA. 298:1763-71.

Fowler VG Jr, Olsen MK, Corey GR, Woods CW, Cabell CH, Reller LB, et al. Clinical identifiers of complicated Staphylococcus aureus bacteremia. Arch Intern Med. 2003;163:2066-72.

Boyle-Vavra S, Daum RS. Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin. Lab Invest. 2007;87:3-9.

Bhutia KO, Singh TSK, Adhikari L, Biswas S. Molecular characterization of community and hospital-acquired methicillin-resistant and methicillin-sensitive Staphylococcus aureus isolates in Sikkim. Indian J Med Res. 2015;142:330-5.

Wu D, Wang Q, Yang Y, Geng W, Wang Q, Yu S, et al. Epidemiology and molecular characteristics of community-associated methicillin-resistant and methicillin-susceptible Staphylococcus aureus from skin/soft tissue infections in a children's hospital in Beijing, China. Diagn Microbiol Infect Dis. 2010;67:1-8.

Kaplan SL, Hulten KG, Gonzalez BE, Hammerman WA, Lamberth L, Versalovic J, et al. Three-year surveillance of community-acquired Staphylococcus aureus infections in children. Clin Infect Dis. 2005;40:1785-91.

Worrall GJ. Acute sore throat. Can Fam Physician. 2007;53:1961-2.

McCracken GH Jr. Diagnosis and management of children with streptococcal pharyngitis. Pediatr Infect Dis. 1986;5:754-9.

Shulman ST. Acute streptococcal pharyngitis in pediatric medicine: current issues in diagnosis and management. Paedia Drugs. 2003;5:13-23.