Pattern of extra pulmonary tuberculosis among urban population with special reference to CBNAAT as a diagnostic tool: a retrospective study at a tertiary care hospital of Odisha, India

C. Mohan Rao, Bhaskar Thakur, Saswat Subhankar, D. P. Dash


Background: Diagnosis of Extra-pulmonary TB (EPTB) is a challenge. Authors wanted to assess the sites of extra-pulmonary involvement during 2013-2017 in a tertiary care hospital cum medical college. Authors also wanted to evaluate the role of Cartridge Based Nucleic Acid Amplification Test (CBNAAT) in diagnosis of EPTB and compare its efficacy with AFB Culture.

Methods: Total 470 EPTB cases diagnosed between 2013 and 2017 from 840 TB treatment records maintained in designated microscopy centre. Specific samples from appropriate sites were taken up for smear for AFB, CBNAAT and AFB culture.

Results: There was incremental detection and registration in both TB and EPTB cases from 96 and 50 cases in 2013 to 246 and 150 cases in 2017 respectively. Among the total 470 EPTB cases in 2013-2017 (55.9%), lymph node followed by pleura and abdomen were the organs having maximum involvement. Bone involvement was more witnessed in adult male than children (p <0.05). There was male preponderance. CBNAAT results were 100 % sensitive and 87.5% specific. Lymph node samples and pus elsewhere in the body had much better diagnostic yield than serous effusions.

Conclusions: Awareness and availability of diagnostic services in tertiary care institutions has lead to increased reporting of EPTB under RNTCP services. CBNAAT can be also be utilized as a point of care testing for lymph node aspirate and pus specimen.



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