DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20183834

Study of prevalence for lactose malabsorption in malnutrition

Sameer Kumar Painkra, Dhannu Ram Mandavi

Abstract


Background: Milk is the major food in the diet of the infant mammal and consequently has always attracted considerable interest from the physician, the industrialist and the mother. The concentration of lactose in milk varies from species to species. Main objective is to study the prevalence of malabsorption in malnutrition.

Methods: Sixty-seven children ranged between ages of 6 months to 3 years, of both sex and varying grades of malnutrition, were studied. Study conducted between July 1979-December 1979. All children were grouped into 4 grades of malnutrition according to Indian Academy of Pediatrics recommendation.

Results: Out of 67 cases, 50 were followed up. Severe malnutrition of grades III and IV (less than 60 percent of expected body weight) comprises 58.2 percent (39 out of 67) in first seen group, and 52 percent (26 out of 50) in follow up group. 59.7 percent Males and 40.3 percent females in first seen cases. 58 percent males and 42 percent females in follow up cases. 24 cases (53.33 percent) of lactose malabsorbers were males and 21 cases (46.67 percent) were females.

Conclusions: Lactose malabsorption is common in protein-energy malnutrition. This can be determined by simple ward tests and abnormal lactose tolerance curve after oral lactose load. Lactose malabsorption increases with the severity of malnutrition. Malnutrition leads to lactose malabsorption and lactose malabsorption is an important contributory factor in production of malnutrition.


Keywords


Malnutrition, Lactose malabsorption, Prevalence

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References


Johnson JD, Kretchmer N, Simoons, FJ. Lactose malabsorption-its biology and history. In Advances in Paed. Ed. Schulman I, Year book Medical Publishers Inc. Chicago. 1974;21:197.

Sunshine P, Kretchmer N. Intestinal disaccharidase absence in two species of sea. Lions; Science. 1964;144:850.

Cajori FA. The enzyme activity of Dogs' intestinal juice and its relation to intestinal digestion. Am J Physiology-Legacy Content. 1933;104(3):659-68.

Borgstorm B, Dahlqvist A, Lundh G, Sjovall J. Studies of intestinal digestion and absorption in the human. J Clin Invest. 1957;36:1521.

Burman MD. Textbook of pediatric nutrition. 2nd Ed. Churchill Livingstone, Edinburgh;1982:114.

Premchander KV, Sundaravalli N, Panchatcharam M, Ranganathan G, Moses LG, Balagopal VR. Pattern of sugar intolerance in children following chronic or recurrent diarrhoea: a preliminary report. Indian pediatrics. 1976 Mar;13(3):177-86.

Udani PM, Parekh UC, Panwlkar RS, Begaumkar TN. Sugar intolerance in diarrhea. Paedia Clin India. 1974;9:3.

Trowell HC. Diseases of children in the subtropics and tropics. London, Edward Arnold Ltd. 1958;171.

Bowie MD, Brinkman GL, DL JH. Acquired disaccharide intolerance in malnutrition. J pediatrics. 1965 Jun 1;66(6):1083-91.

Weijers HA, KAMER JV, Dicke WK, Ijsseling J. Diarrhoea caused by deficiency of sugar splitting enzymes. I. Acta paediatrica. 1961 Jan;50(1):55-71.

Stanfield JP. The diarrhea malnutrition circles. J Trop Paed. 1966;12:53.

Lifshitz F. Disaccharidase deficiency with steatorrhoea. J Paed. 1964;79:760.

Chandrashekharan R. Carbohydrate in tolerance in infants with acute diarrhea and its complications. Acta Paed Scand. 1975;64:483.

Brodbeck U. The isolation and identification of the Beta-protein of lactose synthetase as Alpha- lactalbumin. J Biol Chem. 1967;242:139.