DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20184915

Clinicopathological profile of malaria patients in an Central African United Nations hospital

Kinshuk Kohli, Amit K. Das

Abstract


Background: Malaria is one of the most widespread diseases in the world. It is endemic in 91 countries. Each year 300-500 million cases of malaria are confirmed with 1.5-2.7 million deaths. Malaria is a major public health problem in Africa. A large number of united nations troops are deployed in central Africa making them vulnerable to malaria infection. Present study was undertaken to find out the clinical and laboratory findings of malaria cases in a United Nation’s referral hospital in Central Africa.

Methods: It is a retrospective study of 150 confirmed and treated cases of malaria for a period of one year in a referral hospital for peace keeping troops and employees of United Nations in Democratic Republic of Congo (DRC). Patients positive by ICT or slide positive were included. Detailed history, examination and lab features of these patients were recorded and analyzed.

Results: A total of 150 patients were included in the study. Out of which 145 patients were of pure P. falciparum malaria, 02 patients had only P. vivax, and 03 patients were having mixed malaria. Fever was the main symptoms found in all patients. Headache was the second most predominant symptoms in (70%) patients. Other signs and symptoms were vomiting (31%), myalgia (38%), jaundice (10%), hepatosplenomegaly (15%), pallor (42%) and decreased urine output (8%). Duration of symptoms was between 4 to 15 days. Thrombocytopenia was observed in 43% patients. Jaundice in (10%), transaminitis in (25%). Anaemia was seen in 53% patients.

Conclusions: Malaria was found to be the most common cause of admission in our hospital. It is important to suspect malaria in all persons deployed in DRC and presenting with fever and associated headache, jaundice, transaminitis and thrombocytopenia. Early diagnosis and treatment can be lifesaving to prevent complications and mortality.


Keywords


Anemia, Headache, Thrombocytopenia, Severe malaria

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References


World Health Organization. World Malaria report 2015. Available at: www.who.int/malaria/ media/world_malaria_report_2015/. Accessed on 15 February 2016.

Autino B, Noris A, Russo R, Castelli F. Epidemiology of malaria in endemic areas. Mediterr J Hematol Infect Dis. 2012;4:e2012060.

WHO. World malaria report 2015. Geneva: World Health Organization, 2015. Available at: www.who.int/malaria.

NMCP (PNLP). National Strategic plan for Malaria Control 2014-2018. Brazzaville, 2014.

Preetam N Wasnik, TP Manohar, NR Humaney, HR Salkar. Study of clinical profile of falciparum malaria in a tertiary referral centre in central India. JAPI. 2012;60:33-6.

Vishwanath K, Ronak Raheja, K P Balaraju, Priyanka Karagaiah, Vinayaka GP. Study of clinical and laboratory profile of malaria. J Med Dental Sci. 2014;3(65):14169-674.

Tsumori Y, Ndounga M, Sunahara T, Hayashida N, Inoue M, Nakazawa S, et al. Plasmodium falciparum: differential selection of drug resistance alleles in contiguous urban and peri-urban areas of Brazzaville, Republic of Congo. PLoS ONE. 2011;6:e23430.

WHO. MHP. Entomological profile of Congo, technical Report, Health and Population, Congo, 2006.

NMCP (PNLP). Report of activities of the national malaria control program Year 2015. Brazzaville, 2016.

Deshwal R. Clinical and laboratory profile of hospitalized malarial patients: An Agra-based study. J Association Physicians India. 2016;64:44.

Rasheed A, Saeed S, Khan SA. Clinical and laboratory findings in acute malaria caused by various plasmodium species. international studies. 2009 Apr;14:15.

Sharma SK, Das RK, Das PK, Haematological and coagulation profile in acute falciparum malaria. JAPI. 1992;40:581-3.

Jelia S, Meena S, Meena SR, Arif Md., Jain P, Ajmera D, et al. A study of clinical profile and complications of malaria in a tertiary care centre in South-eastern region of Rajasthan, India. Int J Adv Med. 2016;3:614-20.

Jadhav UM, Patkar VS, Kadam NN. Thrombocytopenia in malaria-correlation with type and severity of malaria. JAPI. 2004 Aug;52(615):8.

Nadkar MY, Huchche AM, Singh R, Pazare AR, clinical profile of Severe plasmodium vivax malaria in a tertiary care centre in Mumbai, from june 2011 to January 2011. J Assoc Physician India. 2012;60:11-3.

Saya RP, Debabrata G, Saya GK. Malarial hepatopathy and its outcome in India. North Am J Med Sci. 2012 Oct;4(10):449.

Muddaiah M, Prakash PS. A study of clinical profile of malaria in tertiary referral centre in south Canara. J Vector Borne Dis. 2006;43:29-33.

Kochar DK, Agarwal P, Kochar SK, Jain R, Rawat N, Pokharna RK, et al. Hepatocyte dysfunction and hepatic encephalopathy in Plasmodium falciparum malaria. QJM. 2003 Jul 1;96(7):505-12.