Correlation between ABO blood groups and various cancers in the north eastern region of India: a retrospective observational study

Chandana Kalita, Anupam Sarma, Jagannath Dev Sharma, Manoj Kalita, Manigreeva Krishnatreya, Amal Chandra Kataki


Background: Numerous studies have documented the association of the ABO blood groups with the occurrence of cancers. Aim was to find out an association of ABO blood groups and various cancers in the North Eastern region of India.

Methods: The study was a retrospective observational study that included 1000 cases and 1000 controls. The data included the ABO blood typing of the selected cancer sites which were head and neck, esophagus, stomach, breast, cervix, and ovary. Patients who attended blood bank of regional cancer center with requisition for blood transfusion from 2014 to 2016 were included. The control group was healthy blood donors. Chi square test was used to assess the difference among the compared groups. Risk was calculated by regression analysis. P value <0.05 was considered as statistically significant at 95% confidence interval.

Results: Out of 1000 cases and 1000 controls, O blood group were seen in 377 (37.7%) and 395 (39.5%) cases and control, respectively. Significant reduced odds ratio (OR) in non O blood groups for head and neck, esophagus, stomach, and breast was observed. In case of carcinoma cervix, OR for B group was 1.5 (P=0.05), and for blood group A OR=2.2 (P=0.02) was seen in carcinoma ovary.

Conclusions: In the studied population, patients with O blood group are at an increased risk of developing head and neck, esophagus, stomach, and breast cancers.


Blood group, Cancer, Correlation, North east India, Risk

Full Text:



Saran RK. Transfusion medicine: technical manual. 2nd ed. New Delhi: Directorate General of Health Services, Ministry of Health and Family Welfare, Govt. of India, 2003.

Liumbruno G, Franchini M. Beyond Immunohaematology: The role of the ABO blood group in human diseases. Blood Trans. 2013;11:491-9.

Luiz C de Mattos, Haroldo W. Genetic of the ABO Blood system and its link with the immune system. Rev Bras Hemtol Hemoter. 2004;26:60-3.

Xu M, Wang F, Glidersleeve J, Achilefu S. MAbL9E10 to Blood groups H2 antigen binds to colon cancer stem cells and inhibits tumor cell migration and invasion. Hybridoma (Larchmt). 2010;29:355-59.

Hauselmann I, Borsig L. Altered tumor cell glycosylation promotes metastasis. Front Oncol. 2014;4:28.

Anstee DJ. Relationship between blood group and disease. Blood. 2010;115:4635-43.

Berger SA, Young NA, Edberg SC. Relationship between infectious diseases and human blood type. Eur J Clin Microbiol Infect Dis. 1989;8:681-89.

Muschel L. Blood groups, diseases and selection. Bacteriol Rev. 1966;30:427-41.

Akhtar K, Mehdi G, Sherwanti R, Soft L. Relationship between various cancers and ABO Blood groups: a Northern experience. Internet J Pathol. 2010;13:11-16.

Guleria K, Kaur H, Sambyal V. ABO Blood groups in gastrointestinal tract and breast carcinoma patients. Anthropologist. 2005;7:189-92.

Flavarjani A, Hedayatpour B, Bashardoost N, Nourian SM. Study of the association between blood types and breast cancer among Isfahanian women. Adv Biomed Res. 2014;3:43.

Saxena S, Chawla V, Gupta K, Gana K. Association of the ABO blood group and breast cancer in Jodhpur. Indian J Physiol Pharma. 2015;59:63-8.

Zhang B, Huang Y, Song F, Chen K. ABO Blood groups and risk of cancer: A systemic review and metaanalysis. Asian Pac J Cancer Prev. 2014;15:4643-50.

Singh K, Kopte S, Patthi B, Singla A, Singh S, Kundu H, Jain S. Relative risk of various head and neck cancers among different Blood groups: An analytical study. J Clin Diagn Res. 2014;8:zc25-zc28.

Saxena S, Gupta K. Association of ABO blood groups in relation to Gynaecological cancer as in Western Rajasthan. Int J Health Sci Res. 2016;6:118-124.

Fotra R, Gupta S, Raina TR, Gupta S. Association of ABO blood groups with carcinoma cervix with special reference to Jammu region. Biosci Biotech Res Asia. 2011;8:313-6.

Poole E, Gates M, High B, Chamock S ,Cramer D, Cuningham J, et al. ABO blood group and risk of epithelial ovarian cancer within the ovarian cancer association consortium. Cancer Causes Control. 2012;23:1805-10.