DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20160321

A study of Helicobacter pylori infection in patients of ischemic cerebro vascular stroke

Vidya Sagar, Khwaja Saifullah Zafar, Granth Kumar

Abstract


Background: The objective of the study was to study the prevalence and association of Helicobacter Pylori infection in patients of ischemic cerebrovascular stroke. Observational analytic cross sectional study.

Methods: Seroprevalence of infection by H. pylori was assessed by History, examination, CT scan Brain, Rapid Urease Test and Elisa in 39 patients with acute cerebral ischemia and 30 age and sex matched control subjects selected randomly from general population with similar socio economic status. The presence of carotid plaques instability was evaluated by color doppler ultrasound.

Results: Hypertension (61.54%) and previous history of cerebral ischemia are clinically significant leading cause of cerebral ischemia among the patients (p < 0.05). The prevalence of infection was mere common (66.66%) in cases than control (40%). The difference is statistically significant (p < 0.05) and this remains significant after controlling other risk factors including socio-economic status. There is no significant association found between H. pylori seropositivity and carotid plaque surface irregularity (x2 = 0.649, P > 0.05).

Conclusions: Our results support the hypothesis of an association between infection with H. pylori and acute cerebral ischemia and there is no significant association found between H. pylori seropositivity and carotid plaque instability.

 


Keywords


Cerebrovascular, Helicobacter pylori, Ischemic, Infection, Stroke

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References


Pietroiusti A, Diomedi M, Silvestrini M. Cytotoxin-associated gene-A-positive Helicobacter pylori strains are associated with atherosclerotic stroke. Circulation. 2002;106:580-4.

Libby P. Changing concepts of atherogenesis. J Intern Med. 2000;247(3):349-58.

De Boer OJ, Van der Wal AC, Becker AE. Atherosclerosis, inflammation and infection. J

Pathol. 2000;190:237-43.

Blasi F, Fagetti L, Allegra L. Chlamydia pneumoniae detection atherosclerotic plaques in Italy. J Infect Dis. 2000;3:S444-6.

Ameriso SF, Fridman EA, Leiguarda RC. Detection of Helicobacter pylori in human carotid atherosclerotic plaques. Stroke. 2001;32:385-91.

Franceschi F, Sepulveda AR, Gasbarrini A, Pola P, Silveri NG, Gasbarrini G, et al. Cross-reactivity of anti-CAG antibodies with vascular wall antigens:possible pathogenic link between Helicobacter pylori infection and atherosclerosis. Circulation. 2002;106(4):430-4.

Mayr M, Kiechl S, Mendall M. Increased risk of atherosclerosis is confined to CagA-positive Helicobacter pylori strains: prospective results from the Bruneck Study. Stroke. 2003;34:610-5.

Heuschmann PU, Neureiter D, Gesslein M, Craiovan B, Maass M, Faller G, et al. Association between infection with helicobacter pylori and chlamydia pneumoniae and risk of ischemic stroke subtypes. [Results from a Population- Based Case-Control Study]. Stroke. 2001;32:2253-58.

Ponzetto A, Marchet A, Pellicano R, Lovera N, Chianale G, Nobili M, et al. Association of Helicobacter pylori infection withischemic stroke of non-cardiacorigin: BAT.MA.N. project study. Hepatol Gasterol. 2002;49(45):631-4.

Moayyedi P, Carter AM, Braunholtz D, Catto AJ. Helicobacter pylori infection in subjects with acute ischaemic stroke. Dig Liver Dis. 2003;35:16-9.

Masoud SA, Arami MA, Kucheki E. Association between infection with Helicobacter pylori and cerebral noncardioembolic ischemic stroke. Neurol India. 2005;53:303-6.