A study of Helicobacter pylori infection in patients of ischemic cerebro vascular stroke

Vidya Sagar, Khwaja Saifullah Zafar, Granth Kumar


Background: The objective of the study was to study the prevalence and association of Helicobacter Pylori infection in patients of ischemic cerebrovascular stroke. Observational analytic cross sectional study.

Methods: Seroprevalence of infection by H. pylori was assessed by History, examination, CT scan Brain, Rapid Urease Test and Elisa in 39 patients with acute cerebral ischemia and 30 age and sex matched control subjects selected randomly from general population with similar socio economic status. The presence of carotid plaques instability was evaluated by color doppler ultrasound.

Results: Hypertension (61.54%) and previous history of cerebral ischemia are clinically significant leading cause of cerebral ischemia among the patients (p < 0.05). The prevalence of infection was mere common (66.66%) in cases than control (40%). The difference is statistically significant (p < 0.05) and this remains significant after controlling other risk factors including socio-economic status. There is no significant association found between H. pylori seropositivity and carotid plaque surface irregularity (x2 = 0.649, P > 0.05).

Conclusions: Our results support the hypothesis of an association between infection with H. pylori and acute cerebral ischemia and there is no significant association found between H. pylori seropositivity and carotid plaque instability.



Cerebrovascular, Helicobacter pylori, Ischemic, Infection, Stroke

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