Hemodynamic response in laparoscopic cholecystectomy after magnesium sulphate versus clonidine administration


  • Vijaya P. Borkar Patil Department of Anesthesiology, Dr PDMMC and Hospital, Amravati, Maharashtra, India
  • Mayuri Ganeshrao Tambakhe Department of Anesthesiology, Grant Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India
  • Sunil Shankarrao Lawhale Department of Anesthesiology, Dr PDMMC and Hospital, Amravati, Maharashtra, India
  • Jayshree J. Upadhye Department of Obstetrics and Gynecology, Rajshree Medical College, Bareily, Uttar Pradesh, India




Clonidine, Laparoscopic cholecystectomy, Magnesium sulfate, Pneumoperitoneum


Background: Magnesium and clonidine both inhibit catecholamine and vasopressin release. They also attenuate hemodynamic response to pneumoperitoneum.

Methods: This randomized double-blind study was designed to assess which agent attenuates hemodynamic stress response to pneumoperitoneum better in 70 patients undergoing laparoscopic cholecystectomy.

Results: After the administration of drug, heart rate in group M was mean 84.29 while in group C was mean 79.89. Thus, there was more fall in Heart rate in C group. After intubation, heart rate at 1min, 3 min, 5 min was 101.20, 96.69, 93.94 respectively in group M and in C group was 96.37, 85.83, 86.17 respectively with p values (0.12, 0.001, 0.008). After giving drug, there was fall in blood pressure in both groups but in C group, there was significant fall in systolic blood pressure. There was no significant difference in the mean diastolic BP in both the groups immediately at intubation (76.17±10.74 for group M and 78.86±10.48 for group C with p>0.05) as also at 3 min (63.29±8.76 for M group and 65.14±11.705 for clonidine with p>0.05) and 5 min (63.03±7.909 for magnesium sulphate and 67.69±13.588 for clonidine with p>0.05) following intubation. Thus, the rise in mean diastolic BP was statistically similar in both Group M and Group C. There was no significant difference in the mean for MAP in both the groups immediately at intubation (88.86±12.76 for magnesium sulphate and 91.74±11.59 for clonidine) as also at 3 min (73.17±10.019 for M and 75.80±12.849 for C group. But at 5 min (71.71±9.11 for magnesium sulphate and 77.66±13.715 for clonidine) following intubation with p<0.05 which is significant.

Conclusions: Administration of magnesium sulfate or clonidine attenuates hemodynamic response to pneumoperitoneum. Although magnesium sulfate produces hemodynamic stability comparable to clonidine, clonidine blunts the hemodynamic response to pneumoperitoneum more effectively.


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How to Cite

Borkar Patil, V. P., Tambakhe, M. G., Lawhale, S. S., & Upadhye, J. J. (2018). Hemodynamic response in laparoscopic cholecystectomy after magnesium sulphate versus clonidine administration. International Journal of Research in Medical Sciences, 6(10), 3239–3245. https://doi.org/10.18203/2320-6012.ijrms20183861



Original Research Articles