Correlation between thyroxin hormone level, bilirubin and uric acid in diabetic subjects


  • Rajendra Dutt Mathur Department of Medicine, SRG and Associated Hospital and Medical College Jhalawar, Rajasthan, India
  • Rameshwar Prasad Gupta Department of Medicine, SRG and Associated Hospital and Medical College Jhalawar, Rajasthan, India
  • Deepak Gupta Department of Medicine, SRG and Associated Hospital and Medical College Jhalawar, Rajasthan, India
  • Ajay Kumar Bhargav Department of Biochemistry, SRG and Associated Hospital and Medical College Jhalawar, Rajasthan, India
  • Reenika Mathur Department of Medicine, SRG and Associated Hospital and Medical College Jhalawar, Rajasthan, India



Bilirubin, T3, T4, TSH, Uric acid


Background: Levels of thyroxin hormone along with T3, TSH and other markers such as uric acid, bilirubin and glucose are important in diagnosis and medical management of diabetes mellitus and thyroid disorder. Relationship between these parameters are important in both diabetes mellitus and Thyroid gland disease, as both disorders are increasing very fast in Indian population. Present study aimed to analyzed T3, T4, TSH, uric acid and bilirubin in Haroti Region of Jhalawar, Rajasthan in diabetic and non diabetic subjects.

Methods: One hundred diabetes mellitus subjects and 100 healthy control subjects were analyzed for determination of thyroxin, T3, TSH, uric acid and bilirubin by commercial kit method.

Results: One hundred subjects of diabetes mellitus between age 30-60 years male and female were analyzed. It was observed significantly T3 <0.001 T4 <0.001 TSH <0.001 bilirubin <0.01 in diabetic subjects and found to be significant when compared in both groups. However, uric acid level insignificant in both patients and control groups.

Conclusions:This study demonstrated that thyroxin hormone with T3, TSH and bilirubin and uric acid, are important parameters and their values are significant when compared with healthy subjects in diabetes mellitus and thyroid disorder. 



King H, Aubent RE, Feerman WH. Global Burdon of diabetes 1995-2025: Prevalence numerical estimates and projection. Diabetes care. 1998;21:1444-143.

Wild S. Rogeic G, Green A, Sicree R, King H. Global Prevalence of diabetes estimates for the year 2000 and projections for 2030. Diabetes care. 2004:27:1047-53.

Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J. In: HARRISON’S Principal of Internal Medicine 18th ed. MC Grawh Hill Publication;2012:2999-3012.

Deetman PE, Bakker SJ, Kwakernaak AJ, Navis G, Dullaart RP, PREVEND Study Group. The relationship of the anti-oxidant bilirubin with free thyroxine is modified by insulin resistance in euthyroid subjects. PloS one. 2014;9(3):e90886.

Waring SW, Webb DJ, Maxwell SR. Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers. J Cardiovas Pharmacol. 2001 Sep 1;38(3):365-71.

Chatterjee MN, Shinde R. In: Textbook of Medical Biochemistry. 8th ed. Jaypee. 2012:550-551.

Tang Y, Yan T, Wang G, Chen Y, Zhu Y, Jiang Z, et al. Correlation between Insulin resistance and thyroid nodule in type 2 diabetes mellitus. Inter J Endocrinol. 2017;2017:1617458.

Satyajit K, Arindam S. Correlation of altered lipid profile, uric acid and fasting plasma glucose levels in females with hypothyroidism. Endocrinol Metab Syndr. 2017;6(275):2161-1017.

Burtis CA, Ashwood ER, Bruns DE. In: Teitz textbook of clinical Chemistry and molecular diagnostics. 5th ed. Philadelphia: Elsevier;2012:1905-1944.

Winsten S, Cehelyk B. A rapid micro diazo technique for measuring total bilirubin. Clinica Chimica Acta. 1969 Sep 1;25(3):441-6.

Trivedi RC, Rebar L, Berta E, Stong L. New enzymatic method for serum uric acid at 500 nm. Clinical Chemistry. 1978 Nov 1;24(11):1908-11.

National Collaborating Centre for Chronic Conditions (UK. Type 2 diabetes: national clinical guideline for management in primary and secondary care (update). Royal College of Physicians (UK); 2008.

Chaker L, Ligthart S, Korevaar TI, Hofman A, Franco OH, Peeters RP, Dehghan A. Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study. BMC medicine. 2016 Dec;14(1):150.

Carraris G J, Manowitz NR, Mayor G, Ridgnlay EC: The colorado thyroid disease preventive study. Arch Intern Med. 2000;160:526-34.

Radaideh AR, Mo MK, Amari FL, Bateiha AE, El-Khateeb MP, Naser PA, et al. diabetes mellitus in Jordan. Saudi Med J. 2004;25(8):1046-50.

Feely J, Isles TE. Screening for thyroid dysfunction in diabetics. British Med J. 1979;2(6202):1439.

Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, et al. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol. 1977 Dec;7(6):481-93.

Papazafiropoulou A, Sotiropoulos A, Kokolaki A, Kardara M, Stamataki P, Pappas S. Prevalence of thyroid dysfunction among Greek type 2 diabetic patients attending an outpatient clinic. J Clinical Med Res. 2010 Apr;2(2):75-8.

Mokuno T, Uchimura K, Hayashi R, Hayakawa N, Makino M, Nagata M, et al. Glucose transporter 2 concentrations in hyper-and hypothyroid rat livers. J Endocrinol. 1999 Feb 1;160(2):285-9.

Handisurya A, Pacini G, Tura A, Gessl A, Kautzky‐Willer A. Effects of T4 replacement therapy on glucose metabolism in subjects with subclinical (SH) and overt hypothyroidism (OH). Clin Endocrinol. 2008 Dec;69(6):963-9.)

Neuzil J, Stocker R. Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation. J Biol Chem. 1994;269(24):16712-9.

Deetman PE, Kwakernaak AJ, Bakker SJ, Dullaart RP. Low-normal free thyroxine confers decreased serum bilirubin in type 2 diabetes mellitus. Thyroid. 2013 Nov 1;23(11):1367-73.

Bhargava AK, Mathur M, Diwan R, Bohra VD. Analysis of serum uric acid and bilirubin in breast cancer. Inter J Sci Res. 2015 Feb;4:2277-8179.

Taniguchi Y, Hayashi T, Tsumura K, Endo G, Fujii S, Okada K. Serum uric acid and the risk for hypertension and Type 2 diabetes in Japanese men: The Osaka Health Survey. J Hypertension. 2001 Jul 1;19(7):1209-15.

Yokogoshi Y, Saito S. Abnormal serum uric acid level in endocrine disorders. Nihon rinsho. Japanese J Clin Med. 1996 Dec;54(12):3360-3.

Oda E, Kawai R, Sukumaran V, Watanabe K. Uric acid is positively associated with metabolic syndrome but negatively associated with diabetes in Japanese men. Internal Med. 2009;48(20):1785-91.

Hage M, Zantout MS, Azar ST. Thyroid disorders and diabetes mellitus. J Thyroid Res. 2011:4394-4397.




How to Cite

Mathur, R. D., Gupta, R. P., Gupta, D., Bhargav, A. K., & Mathur, R. (2018). Correlation between thyroxin hormone level, bilirubin and uric acid in diabetic subjects. International Journal of Research in Medical Sciences, 6(11), 3710–3713.



Original Research Articles