Study of the pathogenesis and diagnosis of ulcer of lower extremity under various conditions

Gajjam Shrinivas A., Wagh Amol


Background: As lower extremities are exposed to injury and having a circulation strained by upright posture of human being should be the site of ulcer. This has reason for researchers and surgeon who have been concerned with the reasons for their common occurrence and difficulty in their cure. Researcher interested to study the pathogenesis of ulcer of lower extremity under various conditions.

Methods: In the present study, 70 patients of lower extremity ulcer with various types were admitted in surgical wards of Mallareddy Institute of Medical Sciences, Hyderabad. The cases were examined in detail and investigated thoroughly. In clinically doubtful cases, the diagnosis was made only after histopathological examination.

Results: Most common type of ulcer was found in the present was Venous 13 (18.57%) cases, contributed by male (12) and female (1) followed by Traumatic 12 (17.14%) and Diabetic 11 (15.74%). Most of cases belong to the age group 41-60 years (47.14) and male (28 cases). High saphenous vein ligation with sripping of veins (23.07%) and conservative (23.07%) treatment were common surgical procedures used for the treatment of venous ulcer.

Conclusions: In the present, venous ulcers are the most common of all leg ulcers with high morbidity. The surgical procedures are directed at prevention of venous reflux at various levels.


Lower extremity, Ulcer, Venous

Full Text:



O’Meara S, Al-Kurdi D, Ovington LG. Antibiotics and antiseptics for venous leg ulcers. Cochrane Database Syst Rev. 2008;(1):CD003557.

de Araujo T, Valencia I, Federman DG, Kirsner RS. Managing the patient with venous ulcers. Ann Intern Med. 2003;138(4):326-34.

W.B.vanGent,E.D.Wilschut,andC.Wittens,“Management of venous ulcer disease,” The British Medical Journal. 2010;341(7782):1092-6.

Karl T, Modic PK, Voss EU. Indications and results of VAC therapy treatments in vascular surgery-state of the art in the treatment of chronic wounds. Zentralbl Chir. 2004;129 supp l1:574- 9.

Collins R,Seraj S. Diagnosis and treatment of venous ulcers.Am Fam Physician. 2010;81:989-96.

González-Consuegra RV, Verdú J. Quality of life in people with venous leg ulcers: An integrative review. J Adv Nurs. 2011;67:926-44.

Briggs M, Nelson EA. Topical agents or dressings for pain in venous leg ulcers. Cochrane Database Syst Rev. 2003;(1):CD001177.

Nelzén O, Bergqvist D, Lindhagen A. Long-term prognosis for patients with chronic leg ulcers: a prospective cohort study. Eur J Vasc Endovasc Surg . 1997;13(5):500-8.

Samson RH, Showalter DP. Stockings and the prevention of recurrent venous ulcers. Dermatol Surg. 1996;22(4):373-376.

Collins L, Seraj S. Diagnosis and treatment of venous ulcers. The American Family Physician. 2010; 81(8):989-96.

Grey JE, Harding KG, Enoch S. Venous and arterial leg ulcers. The British Medical Journal. 2006;332(7537):347-50.

Gostishchev VK, Khokhlow AM. Pathogenesis of trophic ulcers in varicose veins of the lower extremities. Khirurgiia (Mosk). 1991;10:100-5

Faria E, Blanes L, Hochman B, Filho MM, Ferreira L. Health-related quality of life, self-esteem, and functional status of patients with Leg ulcers. Wounds. 2011;23(1):4-10.

C. Moffatt,. Leg ulcers in Vascular Disease, S. Murray, Ed., pp.200–237, Whurr Publishers, London, UK, 2001.

Adeyi A, Muzerengi S, Gupta I. Leg ulcers in older people: a review of management. The British Journal of Medical Practitioners. 2009;2(3):21-8.

Pendse SP. Understanding diabetic foot. International Journal of Diabetes in Developing Countries. 2010;28(5):519-26.

Clayton W, Elasy TA. A review of the pathophysiology, classification, and treatment of foot ulcers in diabetic patients. Clinical Diabetes. 2009;27(2):52-8.