Correlation of fine needle aspiration cytology with histopathological diagnosis in assessing breast lumps at a tertiary care hospital

Authors

DOI:

https://doi.org/10.18203/2320-6012.ijrms20184440

Keywords:

Breast, Cytological, FNAC, Histopathological

Abstract

Background: Breast cancer is one of the most common malignancies in women worldwide (22%) and India ranks the second after cervical cancer. The diagnostic accuracy of FNAC increases to 99% when it is combined with clinical and radiological examination. In this study, authors plan to correlate the cytological findings with histopathological examinations for breast lesions and determine the accuracy of fine needle aspiration cytology in the diagnosis of breast lesions.

Methods: It is a retrospective study carried out in the Department of Pathology at a Tertiary Care Hospital. All the FNAC results of breast lesions during the one year period were collected. Gauge needle maximum of 3 passes were made and the slides were fixed in 70-80% alcohol and stained with routine haematoxylin and eosin stain.

Results: Among 200 patients, 197 were females and 3 were males. Benign breast lesions were found in 158 cases; among which fibroadenoma was the commonest lesion. Malignancy was observed in 25 cases. Two cases of phyllodes tumour were incorrectly reported as fibroadenoma on cytology. Of 12 cases which were diagnosed to have atypical lesions, 4 cases were papillary neoplasm, and 8 cases were atypical ductal hyperplasia.

Conclusions: This study concludes that breast FNAC is a reliable, easy, cheap and effective procedure for the diagnosis. It reduces the need of core needle biopsies and very well correlated with histopathological examination. FNAC differentiates non neoplastic from the neoplastic by which it reduces the patient’s anxiety and helps the surgeons in planning the mode of treatment.

References

Ramachandra K, Kamaleshwar S, Sand TS. A study on risk factors of breast cancer among patients attending the tertiary care hospital in Udupi district. Indian J Community Med. 2013;38(2);95-99.

Yong WS, Chia KH, Poh WT and Wong CY. A comparison of trucut biopsy with fine needle aspiration cytology in the diagnosis of breast cancer. Singapore Med J. 1999;40(9):587-9.

Rahman MZ, Islam S. Fine needle aspiration cytology of palpable breast lump: a study of 1778 cases. Surgery. S12:001.

Obaseki DE, Olu-Edo AN, Ogunbiyi JO. Diagnostic accuracy of fine needle aspiration cytology of palpable breast masses in Benin City, Nigeria. West Afr J Med. 2010;29(4):259-62.

Kaufman Z, Shpitz B, Shapiro M, Rona R, Lew S, Dinbar A. Triple approach in the diagnosis of dominant breast masses: combined physical examination, mammography, and fine‐needle aspiration. J Surg Oncol. 1994 Aug;56(4):254-7.

Daramola AO, Odubanjo MO, Obiajulu FJ, Ikeri NZ, Banjo AA. Correlation between fine-needle aspiration cytology and histology for palpable breast masses in a Nigerian Tertiary Health Institution. International Journal of breast Cancer. 2015;2015.

Ukah CO, Oluwasola OO. The clinical effectiveness of fine needle aspiration biopsy in patients with palpable breast lesions seen at the University College Hospital, Ibadan, Nigeria: A 10-year retrospective study. J Cytol. 2011;28(3):111-3.

Basnet S, Talwar OP. Role of cell block preparation in neoplastic lesions. J Pathology Nepal. 2012 Jan 1;2(4):272-6.

Dowlatshahi K, Jokich PM, Schmidt R, Bibbo M, Dawson PJ. Cytologic diagnosis of occult breast lesions using stereotaxic needle aspiration: a preliminary report. Archives Surg. 1987 Nov 1;122(11):1343-6.

Evans WP, Cade SH. Needle localization and fine-needle aspiration biopsy of nonpalpable breast lesions with use of standard and stereotactic equipment. Radiology. 1989 Oct;173(1):53-6.

Adnan K, Razza J, Muneeb J, Maria T. Correlation of fine needle aspiration cytology and histopathology diagnosis in the evaluation of breast lumps. Inter J Medical Students. 2014;2(2):40-3.

Jindal U, Singh K, Kochhar A. Fine needle aspiration cytology of breast lumps with histopathological correlation: a four year and eight month study from rural India. Internet J Pathol. 2012;13(3).

Walker SR. A randomized controlled trial comparing a 21 G needle with a 23 G needle for Fine needle aspiration of breast lumps. R Coll Surg Edinb. 1998;43:322-3.

Abdel-Hadi M, Abdel-Hamid GF, Abdel-Razek N, Fawzy RK. Should fine-needle aspiration cytology be the first choice diagnostic modality for the assessment of all nonpalpable breast lesions? The experience of a breast cancer screening center in Alexandria, Egypt. Diag Cytopathol. 2010;38(12):880-9.

Das DK. Fine Needle aspiration Cytology: Its origin, development and present status with special reference to a developing country, India. Diag Cytopathol. 2003;28(6):345-51.

Franzen S, Zajicek J. Aspiration biopsy in the diagnosis of palpable lesions of the breast: Critical review of 3479 consecutive biopsies. Acta Radiol Ther Phys Biol. 1968;7:241-62.

Berner A, Torill Sauer T. Fine-needle Aspiration Cytology of the Breast. Ultra Pathol. 2011;35(4):162-7.

Thakkar B, Parekh M, Trivedi NJ, Agnihotri AS, Mangar U. Role of fine needle aspiration cytology in palpable breast lesions and its correlation with histopathological diagnosis. National J Med Res. 2014;4(4):283-8.

Panjvani SI, Parikh BJ, Parikh SB, Chaudhari BR, Patel KK, Gupta GS, et al. Utility of fine needle aspiration cytology in the evaluation of breast lesions. JCDR. 2013 Dec;7(12):2777-79.

Pruthi S. Detection and evaluation of a palpable breast masses. Mayo Clin Pro. 2001;76(6):641-8.

Downloads

Published

2018-10-25

How to Cite

George, G. A., & Antony, P. (2018). Correlation of fine needle aspiration cytology with histopathological diagnosis in assessing breast lumps at a tertiary care hospital. International Journal of Research in Medical Sciences, 6(11), 3738–3742. https://doi.org/10.18203/2320-6012.ijrms20184440

Issue

Section

Original Research Articles