Anaplastic carcinoma of thyroid: with osteoclast like giant cells: an extremely unusual finding in fine needle aspiration cytology


  • Mourouguessine Vimal Department of Pathology, Sri Manakula Vinayagar Medical College and Hospital, Kalitheerthalkuppam, Madagadipet, Puducherry 605107
  • Tukkaram Chitra Department of Pathology, Karpaga Vinayaga Institute of Medical Sciences, GST Road, Chinna Kolambakkam, Palayanoor PO, Madurantagam Tk, Kancheepuram 603308, Tamilnadu



Anaplastic carcinoma of thyroid, Osteoclast like giant cells, Fine needle aspiration cytology


Anaplastic carcinoma of thyroid is a very rare malignant entity with aggressive behaviour. The FNAC finding of Osteoclast like giant cell in this malignancy is a very rare event with only hand full of cases are reported in the literature. This case report highlights the significance of cytological diagnosis of Anaplastic carcinoma of thyroid with Osteoclast like giant cell in a 70 year old man using simple FNAC technique and its role in determining the treatment plan.


Mehdi G, Ansari HA, Siddiqui SA. Cytology of anaplastic giant cell carcinoma of the thyroid with osteoclast-like giant cells—A case report. Diagn Cytopathol. 2007;35(2):111-2.

Lee JS, Lee MC, Park CS, Juhng SW. Fine needle aspiration cytology of anaplastic carcinoma with osteoclastlike giant cells of the thyroid. A case report. Acta Cytol. 1996;40(6):1309-12.

Joseph L, Ravi A, Rekha A, Rao S, Aarthi R, Panicker V. Osteoclastoma-like anaplastic carcinoma of the thyroid. J Cytol. 2008;25(2):65.

Batori M, Chatelou E, Straniero A, Ruggieri M. Anaplastic thyroid carcinoma: a case of a young women that reports a survival exceeding 6 years. Eur Rev Med Pharmacol Sci. 2007;11(1):69.

Güneş P, Aker FV, Erkan M, Demirtürk P, Dulundu E. Incidental anaplastic thyroid carcinoma: a case report. Turk J Pathol. 2008;24:54-8.

Ragazzi M, Ciarrocchi A, Sancisi V, Gandolfi G, Bisagni A, Piana S. Update on anaplastic thyroid carcinoma: morphological, molecular, and genetic features of the most aggressive thyroid cancer. Int J Endocrinol. 2014:790834.

Valand AG, Ramraje SN, Shedge R, Aware S. Anaplastic thyroid carcinoma with osteoclast-like giant cells. J-Assoc Physicians India. 2004;52:585-6.

Chiacchio S, Lorenzoni A, Boni G, Rubello D, Elisei R, Mariani G. Anaplastic thyroid cancer: prevalence, diagnosis and treatment. Minerva Endocrinol. 2008;33(4):341-57.

Han KM, Kim DH, Lee W. Aspiration Cytology of the Osteoclastic Variant of Anaplastic Thyroid Carcinoma: with Special Emphasis on the Undifferentiated Mononuclear Cells. Korean J Pathol. 2010;44(6):682.

Esmaili JH, Hafez GR, Warner TF. Anaplastic carcinoma of the thyroid with osteoclast-like giant cells. Cancer. 1983;52(11):2122-8.




How to Cite

Vimal, M., & Chitra, T. (2016). Anaplastic carcinoma of thyroid: with osteoclast like giant cells: an extremely unusual finding in fine needle aspiration cytology. International Journal of Research in Medical Sciences, 4(2), 666–668.



Case Reports