DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20184683

Evaluation of anti-diabetic prescriptions at Tripura medical college and Dr. BRAM teaching hospital: a cross- sectional study

Lakshman Das, Shubhaleena Debnath, Prithul Bhattacharjee

Abstract


Background: Diabetes mellitus (DM) is a chronic disease which requires lifelong treatment. The management of type 1 DM depends mainly on insulin, whereas the oral anti-diabetic drugs (OADs) are the first line treatment for type 2 DM. Rational use of the drugs in populations can be effectively studied by analysing the prescription pattern. As there are limited numbers of studies carried out on drug utilization in diabetic patients in North Eastern region of India, authors planned to carry out this study in a tertiary care set up of this region.

Methods: A cross-sectional study was carried out in Medicine OPD of Tripura Medical College and Dr. BRAM Teaching Hospital for a period of two months with the objectives of prescription pattern evaluation and the cost of anti-diabetic agents. Drug use pattern of antidiabetics, WHO core prescribing indicators and percentage of cost variation were analysed.

Results: A total of 120 prescriptions were analysed during the study period. Metformin was the most commonly prescribed drug. The average cost of therapy per prescription per week was Rs. 94.54. Only 19.43% of the antidiabetics were prescribed from the essential drug list.

Conclusions: The cost of prescription can be reduced by choosing the generic drugs without changing its quality and also by choosing drugs from essential drug list.


Keywords


Antidiabetic agents, Diabetes mellitus, Generic medicines, Prescription Pattern

Full Text:

PDF

References


World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1, Diagnosis and classification of diabetes mellitus. Geneva. World Health Organization. 1999. Available at: http://www.who.int/iris/handle/10665/66040 Accessed 19 October 2018.

Arshad K, Kumar S. A study on drug utilization of oral hypoglycemic agents in type-2 diabetic patients. Asian J Pharm Clin Res. 2011;4:60-4.

Day C. The rising tide of type 2 diabetes. The Br J Diabetes Vascular Dis. 2001 Aug;1(1):37-43.

Chaudhari VP, Ganguly B. Changing pattern of prescribing antidiabetic agents in patients suffering from diabetes mellitus. Int J Basic Clin Pharmacol. 2013;2(1):47-50.

Hermansen K, Mortensen LS, Hermansen ML. Combining insulins with oral antidiabetic agents: effect on hyperglycemic control, markers of cardiovascular risk and disease. Vascular Health Risk Management. 2008 Jun;4(3):561.

Gama H. Drug utilization studies. Arq Med 2008;22(2/3):69-74.

Karande S, Sankhe P, Kulkarni M. Patterns of prescription and drug dispensing. Indian J Pediatrics. 2005 Feb 1;72(2):117-21.

Misra B, Jain SK, Mehta Y. A study on availability and prices of medicines in India. National Pharmaceutical Pricing Authority, 2002.

CIMS-Asia. Available at: http://www.cimsasia.com Accessed 19 October 2018.

Malik A, Malik S. Indian Drug Review Compendium. 1st ed. India: Mediworld Publications; 2012.

Acharya KG, Shah KN, Solanki ND, Rana DA. Evaluation of antidiabetic prescriptions, cost and adherence to treatment guidelines: A prospective, cross-sectional study at a tertiary care teaching hospital. J Basic Clin Pharmacy. 2013 Sep;4(4):82.

Sivasankari V, Manivannan E, Priyadarsini SP. Drug utilization pattern of anti-diabetic drugs in a rural area of Tamilnadu, South India- a prospective, observational study. Int J Pharm Biol Sci. 2013 Jan;4:514-9.

Sultana G, Kapur P, Aqil M, Alam MS, Pillai KK. Drug utilization of oral hypoglycemic agents in a university teaching hospital in India. J Clin Pharmacy Therapeutics. 2010 Jun;35(3):267-77.

Upadhyay DK, Palaian S, Ravi Shankar P, Mishra P, Sah AK. Prescribing pattern in diabetic outpatients in a tertiary care teaching hospital in Nepal. J Clin Diagnostic Res. 2007 Aug 1;1(4):248-55.

Agarwal AA, Jadhav PR, Deshmukh YA. Prescribing pattern and efficacy of anti-diabetic drugs in maintaining optimal glycemic levels in diabetic patients. J Basic Clin Pharmacy. 2014 Jun;5(3):79.

MO A, CN A, JM O. Outpatient utilization of anti-diabetic drugs in the South Eastern Nigeria. Int J. Drug Dev Res. 2009;Sept-December;1(1):27.

Adhikari PM, Pai MR. Drug utilisation study in geriatric type 2 diabetic patients. J Clin Diagnostic Res. 2007;1(5):440-3.

Truter I. An investigation into antidiabetic medication prescribing in South Africa. J Clinical Pharmacy Therapeutics. 1998 Dec;23(6):417-22.

Sultana G, Kapur P, Aqil M, Alam MS, Pillai KK. Drug utilization of oral hypoglycemic agents in a university teaching hospital in India. J Clin Pharmacy Therapeutics. 2010 Jun;35(3):267-77.

Hassan Y, Mathialagan A, Awaisu A, Aziz NA, Yahaya R, Salhani A. Trend in the use of oral hypoglycemic agents in an outpatient pharmacy department of a tertiary hospital in Malaysia (2003‑2006). Asian J Pharm Clin Res. 2009;2:40‑6.

Sivasankari V, Manivannan E, Priyadarsini SP. Drug utilization pattern of anti-diabetic drugs in a rural area of Tamilnadu, South India - a prospective, observational study. Int J Pharm Bio Sci. 2013;4(1):514-9.

Das P, Das BP, Rauniar GP, Roy RK, Sharma SK. Drug utilization pattern and effectiveness analysis in diabetes mellitus at a tertiary care centre in eastern Nepal. Indian J Physiol Pharmacol. 2011;55(3):272-80.

Baby N, Tom C, Joseph AA, Abraham A, Nanjwade BK. Prescribing pattern of antidiabetic drugs for type 2 diabetic in tertiary care teaching hospital. World J Pharmacy Pharmaceutical Sci. 2017;6(3):1302-15.

Raj K, Kamlesh K, Kajal HL. A study of drug prescribing pattern and cost analysis among diabetic patients in a tertiary care teaching institute in north india. J Drug Delivery Therapeutics. 2013;3(2):56-61.