Study of histopathological spectrum of gallbladder in cholecystectomy specimens

Authors

  • Gomathi Srinivasan Department of Pathology, Govt. Omandurar Medical College, Chennai-2, Tamilnadu, India
  • A. Sagaya Inba Sekar Department of Surgery, Govt. Omandurar Medical College, Chennai-2, Tamilnadu, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20190363

Keywords:

Cholelthiasis, Cholecystitis, Cholecystectomy, Calculous cholecystitis, Mixed stones, Pigment stones

Abstract

Background: Cholecystitis is one of the most common indications for abdominal surgery. Routine examination of gallbladder grossly and microscopically shows lot of interesting findings. This study aims to quantify the various outcomes of routine gallbladder examination following cholecystectomy procedure.

Methods: All clinical details and data from case sheet and patient history are collected and analysed for all the patients who underwent cholecystectomy surgery in the Department of General Surgery, Govt. Omandurar Medical College, Chennai, from August 2017 to August 2018. The Study period of this study was from August 2017 to August 2018. Three sections each from neck, body and fundus taken. Tissues were processed in automated tissue processor and paraffin blocks made. Statistical analysis of the data was done.

Results: Total number of specimens received were 36. And among the cases the number of females were 33 and the number of males were 3. The number of cases of calculous cholecystitis were 31 and the number of cases with pigment stones were 26, number of cases with cholesterol stone were 2 and the number of cases with mixed stones were 3. The number of cases of acalculous cholecystitis were 5. The number of cases of cholecystectomy by laproscopy were 30 whereas the number of cases of cholecystectomy by open procedure were 6. Chronic cholecystitis was seen in 34 cases and chronic cholecystitis with stones was seen in 29 cases and chronic cholecystitis without stones was seen in 5 cases and Acute on chronic cholecystitis with pigment stone was seen in 1 case and xanthogranulomatous cholecystitis with pigment stone was seen in 1 case.

Conclusions: The risk factors for developing chronic cholecystitis was seen in female gender. The predominant histomorphological pattern seen in this study group is chronic calculous cholecystitis. And the predominant type of stone found in this study is pigment stone compared to mixed and cholesterol stone.

Author Biography

Gomathi Srinivasan, Department of Pathology, Govt. Omandurar Medical College, Chennai-2, Tamilnadu, India

 

 

References

Kumar H, Kini H, Tiwari A. Histological evaluation of 400 cholecystectomy specimens. J Pathol Nepal. 2015 Jan 1;5(10):834-40.

Rosai J. Ackermann surgical pathology. 8th ed. Elsevier. 1996:943-963.

Tyagi SP, Tyagi N, Maheshwari V, Ashraf SM, Sahoo P. Morphological changes in diseased gall bladder: a study of 415 cholecystectomies at Aligarh. J Ind Med Association. 1992 Jul;90(7):178-81.

Liew PL, Wang W, Lee YC, Huang MT, Lin YC, Lee WJ. Gallbladder disease among obese patients in Taiwan. Obesity Surg. 2007 Mar 1;17(3):383-90.

Csendes A, Burdiles P, Smok G, Csendes P, Burgos A, Recio M. Histologic findings of gallbladder mucosa in 87 patients with morbid obesity without gallstones compared to 87 control subjects. J Gastrointestinal Surg. 2003 Aug 1;7(4):547-51.

Katsika D, Tuvblad C, Einarsson C, Lichtenstein P, Marschall HU. Body mass index, alcohol, tobacco and symptomatic gallstone disease: a Swedish twin study. J Int Med. 2007 Nov;262(5):581-7.

Kriska AM, Laporte RE, Patrick SL, Kuller LH, Orchard TJ. The association of physical activity and diabetic complications in individuals with insulin dependent diabetes-The epidemiology of diabetes complications study-VII. J Cli Epidemiol. 1991:44(11);1207-14.

Kafle SU, Sinha AK, Pandey SR. Histomorphology spectrum of gall bladder pathology in cholecystectomy specimens with clinical diagnosis of chronic cholecystitis. J Nepal Med Association. 2013;52(192).

Franco V, Aragona F, Genova G, Florena AM, Stella M, Campesi G. Xanthogranulomatous cholecystitis. Histopathological study and classification. Pathol Res Prac. 1990 Jun;186(3):383-90.

Gupta SC, Misra V, Singh PA, Roy A, Misra SP, Gupta AK. Gall stones and carcinoma gall bladder. Indian J Pathol Microbiol. 2000 Apr;43(2):147-54.

Ganesh IM, Subramani D, Halagowder D. Mucin glycoarray in gastric and gallbladder epithelia. J Carcinogenesis. 2007;6:10.

Dittrick GW, Thompson JS, Campos D, Bremers D, Sudan D. Gallbladder pathology in morbid obesity. Obesity surgery. 2005 Feb 1;15(2):238-42.

Downloads

Published

2019-01-25

How to Cite

Srinivasan, G., & Sekar, A. S. I. (2019). Study of histopathological spectrum of gallbladder in cholecystectomy specimens. International Journal of Research in Medical Sciences, 7(2), 593–599. https://doi.org/10.18203/2320-6012.ijrms20190363

Issue

Section

Original Research Articles