Plasma levels of vitamin B12, epidermal growth factor and tumor necrosis factor alpha in patients with alzheimer dementia

Hatice Ferhan Komurcu, Nedret Kilic, Melike Erol Demirbilek, Kadir Okhan Akin


Background: It was previously reported that vitamin B12 (Vit B12) has the regulatory effects on epidermal growth factor (EGF) and tumor necrosis factor alpha (TNF-α). The role of Vit B12, EGF and TNF-α in the pathogenesis of alzheimer dementia has not been elucidated yet. In this study the plasma Vit B12, EGF and TNF-α level were examined in individuals, between 65-99 years old with and without alzheimer dementia (AD).  

Methods: The study group comprised 47 patients with AD and 38 cases without dementia. EGF and TNF-α were analyzed by ELISA, and Vit B12 was analyzed by chemiluminescence method.

Results: Vit B12 and EGF levels were significantly lower (p<0.0001), whereas TNF-α levels were significantly higher (p<0.0001) in the AD group in comparison to those without AD.  

Conclusions: Our results suggest that Vit B12, EGF and TNF-α may have a role in the pathophysiology of AD.  


Alzheimer dementia, Vitamin B12, Epidermal growth factor, Tumor necrosis factor alpha

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