DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20160519

Prevalence of human immunodeficiency virus infection among the diagnosed tuberculosis patients in Karachi, Pakistan

Abid Ali Channa, Nazia Jameel, Rehana Khalil

Abstract


Background: People living with HIV are from 26-31 times more likely to develop TB than persons without HIV. TB is the most common presenting illness among people living with HIV, including among those taking antiretroviral treatment and it is the major cause of HIV-related death. HIV/AIDS has driven TB epidemics in a number of countries including Pakistan where Tuberculosis is endemic and is a major public health challenge. People living with HIV/AIDS continue to be a group at high risk for tuberculosis (TB). National surveillance is important to indicate the magnitude and burden of both diseases. To control the problem, the WHO recommends the establishment of coordinated strategy for both diseases. In this study we aimed to determine the prevalence of HIV/AIDS among diagnosed Tuberculosis (TB) patients in Karachi, Pakistan.

Methods: A cross sectional study was conducted, in the year 2015 among the diagnosed TB patients to detect TB/HIV co-infection in the two selected sentinel sites of Karachi, Pakistan. Trained investigators used a standardized multiple-choice and open-ended questionnaire to collect the data regarding demographic profile and collected samples for HIV tests of identified cases. Written informed consent was obtained and questionnaire was completed by respondents selected through simple random sampling. 1257 TB patients underwent the rapid assay for HIV serological testing and subsequent ELISA test was done for confirmation of the HIV. The data were analyzed using IBM SPSS Statistics version 20.0 and Microsoft excel.

Results: Among the 1257 patients tested 680 (54%) were men and 577 (46%) women and largest number of patients 56% belonged to the age group 19-40 years. In our study prevalence of HIV among identified Tuberculosis patients was 1.4%.

Conclusions: The prevalence of HIV/AIDS among Tuberculosis patients is 1.4%. Future research needs to be directed toward this sensitive issue and social support programs with treatment services should be ensured for HIV positive TB patients to reduce the disparities in provision of health services for this vulnerable stratum of our society.

 


Keywords


Tuberculosis, Prevalence of HIV/TB co-infection, Diagnosed tuberculosis patients, Prevalence of HIV

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References


Toossi Z. Virological and immunological impact of tuberculosis on human immunodeficiency virus type 1 disease. J Infect Dis. 2003;188:1146-55.

Whalen C, Horsburgh CR, Hom D, Lahart C, Simberkoff M, Ellner J. Accelerated course of human immunodeficiency virus infection after tuberculosis. Am J Respir Crit Care Med. 1995;151:129-35.

HIV-Associated Tuberculosis, World Health Organization, HVTB UPDATES. Available at: http://www.who.int/tb/challenges/hiv/tbhiv_factsheet_2015.pdf?ua=1. Access on 28th December 2015.

World Health Organization. Global tuberculosis control 2009. Geneva: World Health Organization, 2009.

World Health Organization. Global tuberculosis: surveillance, planning, financing. Geneva: World Health Organization, 2006.

WHO, EMRO Stop Tuberculosis. Available on: http://www.emro.who.int/pak/programmes/stop-tuberculosis.html. Access on 10th October 2015.

Population explosion in Karachi. Available at: http://tribune.com.pk. Accessed on 26 September 2015.

Health, Society for the protection of the rights of the child, SPARC Retrieved from: http://www. sparcpk.org/Health.html. Accessed on 7th January 2016.

TDR, research on diseases of poverty. Retrieved from : http://www.who.int/tdr/research/tb_hiv/en/. Accessed on 26 September 2015.

Corbett EL, Watt CJ, Walker N, Maher D, Williams BG, Raviglione MC, Dye C. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch Intern Med. 2003;163:1009-21.

Prasad R, Verma SK, Kumar Y, Nag VL, Tripathi AK. A clinico-radiological study of patients of tuberculosis with HIV co-infection. Current medical trends 2006;10:1971-77.

National AIDS Control Organisation (NACO). 2003. Available at: http://www.nacoonline.org/ guidelines/HIV-TB_guidelines.pdf. Accessed on 26 December 2015.

Sharma SK, Mohan A, Kadhiravan T. HIV-TB co-infection: epidemiology, diagnosis & management, Indian J Med Res. 2005;121:550-67.

Havlir DV, Barnes PF. Tuberculosis in patients with human immunodeficiency virus infection. N Engl J Med. 1999;340:367-73.

Jones BE, Young SM, Antoniskis D, Davidson PT, Kramer F, Barnes PF. Relationship of the manifestations of tuberculosis to CD4 cell counts in patients with human immunodeficiency virus infection. Am Rev Respir Dis. 1993;148:1292-7.

Zumla A, Malon P, Henderson J, Grange JM. Impact of HIV infection on tuberculosis. Postgrad Med J. 2000;76:259-68.

Perlman DC, el-Sadr WM, Nelson ET, Matts JP, Telzak EE, Salomon N et al. Variation of chest radiographic patterns in pulmonary tuberculosis by degree of human immunodeficiency virus-related immunosuppression. The terry beirn community programs for clinical research on AIDS (CPCRA). The AIDS clinical trials group (ACTG). Clin Infect Dis. 1997;25:242-6.

WHO TB‐HIV 2009 Factsheet. Available at: http://www.who.int/tb/challenges/hiv/factsheet_hivtb_2009update.pdf. Accessed on 26 December 2015.